Announcements Trials
Browse Landscape

Phase

Phase 1 3Phase 3 1Phase 2 1Phase 1/2 1

Status

Active not recruiting 4Withdrawn 1Completed 1

Sponsor Class

OTHER 9INDUSTRY 6NIH 4

Study Type

Interventional 6

Sponsor

Cancer Type

CNS 6

Conditions

Carcinoma, Non-Small-Cell Lung 7Neurofibromatosis 1 6Neoplasm Metastasis 6Solid Tumours 5Neoplasms 5Melanoma 5Neurofibroma, Plexiform 4Lung Neoplasms 3Colorectal Neoplasms 3Breast Neoplasms 2Biliary Tract Neoplasms 2Uveal Melanoma 1Solid Tumors 1Renal Insufficiency 1Parkinson Disease 4, Autosomal Dominant Lewy Body 1Pancreatic Neoplasms 1Muscle Invasive Bladder Cancer 1Locally Advanced or Metastatic Solid Tumors 1Kidney Neoplasms 1Healthy Volunteers Pharmacokinetic Study 1Disease Progression 1Differentiated Thyroid Cancer 1Colonic Neoplasms 1Advanced Non Small Cell Lung Cancer 1Advanced Cancer 1

Interventions

AZD 6244 6trametinib 1mirdametinib 1lorlatinib 1encorafenib 1dabrafenib 1binimetinib 1Everolimus 1Dosage Forms 1Control Groups 1Cetuximab 1Acetaminophen 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
INDUSTRY × Neurofibromatosis 1 × AZD 6244 × Clear all
NCT05101148 2026-05-20

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

AstraZeneca

Phase 1 Active not recruiting
24 enrolled
CNS

Neurofibromatosis 1

NCT04590235 2026-05-14

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

AstraZeneca

Phase 1 Active not recruiting
32 enrolled
CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT04924608 2026-03-23

KOMET

AstraZeneca

Phase 3 Active not recruiting
145 enrolled 17 charts 1 FDA
CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT05309668 2025-12-18

SPRINKLE

AstraZeneca

Phase 1/2 Active not recruiting
36 enrolled 37 charts
CNS

Neurofibromatosis 1

NCT05825365 2023-08-14

PROTECT

AstraZeneca

Phase 2 Withdrawn
CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT04495127 2023-04-26

Selumetinib Paediatric NF1 Japan Study

AstraZeneca

Phase 1 Completed
12 enrolled
CNS

Neurofibromatosis 1

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