Announcements Trials
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Phase

Phase 2 1Phase 1 1

Status

Recruiting 9Active not recruiting 5Completed 2Terminated 1Not yet recruiting 1

Sponsor Class

OTHER 1NIH 1

Study Type

Interventional 2

Sponsor

Cancer Type

Sarcoma 2CNS 2

Conditions

Breast Neoplasms 217Neoplasms 196Carcinoma, Non-Small-Cell Lung 94Colorectal Neoplasms 92Prostatic Neoplasms 79Lung Neoplasms 74Multiple Myeloma 49Head and Neck Neoplasms 48Neoplasm Metastasis 46Melanoma 46Pancreatic Neoplasms 44Leukemia, Myeloid, Acute 41Carcinoma, Hepatocellular 41Recurrence 35Brain Neoplasms 35Squamous Cell Carcinoma of Head and Neck 34Ovarian Neoplasms 32Glioblastoma 30Uterine Cervical Neoplasms 29Precursor Cell Lymphoblastic Leukemia-Lymphoma 28Sarcoma 27Glioma 27Lymphoma, Non-Hodgkin 26Lymphoma 26Stomach Neoplasms 25Carcinoma, Renal Cell 25Lymphoma, Follicular 24Colonic Neoplasms 24Motor Activity 22Esophageal Neoplasms 22

Interventions

Sirolimus 1Magnetic Resonance Spectroscopy 1AZD 6244 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Completed × Neurofibrosarcoma × 90 days × Clear all
NCT02211768 2026-05-29

Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1

National Institutes of Health Clinical Center (CC)

Phase 1 Completed
10 enrolled
CNSSarcoma

Neurofibromatoses, Neurofibrosarcoma

NCT03433183 2026-05-27

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

Sarcoma Alliance for Research through Collaboration

Phase 2 Completed
21 enrolled 12 charts
CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

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