Announcements Trials
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Phase

Phase 2 2Phase 1/2 1

Status

Not yet recruiting 1Completed 1

Sponsor Class

OTHER 2

Study Type

Interventional 2

Sponsor

Cancer Type

Sarcoma 2CNS 2

Conditions

Carcinoma, Non-Small-Cell Lung 11Neurofibromatosis 1 9Melanoma 6Neurofibroma, Plexiform 5Pancreatic Neoplasms 3Lung Neoplasms 3Colorectal Neoplasms 3Carcinoma, Hepatocellular 3Breast Neoplasms 3Triple Negative Breast Neoplasms 2Thyroid Neoplasms 2Thyroid Cancer, Papillary 2Sarcoma 2Neurofibrosarcoma 2Gallbladder Neoplasms 2Bile Duct Neoplasms 2Uveal Melanoma 1Thymoma 1Small Cell Lung Carcinoma 1Recurrence 1Peripheral Nervous System Diseases 1Non-small Cell Lung Cancer Metastatic 1Neuroma, Acoustic 1Neurofibromatosis 2 1Neuroblastoma 1Neoplasms, Nerve Tissue 1Neoplasm Metastasis 1Myelodysplastic-Myeloproliferative Diseases 1Myelodysplastic Syndromes 1Multiple Myeloma 1

Interventions

Doxorubicin 5brostallicin 2Sorafenib 2Radiation Dose Hypofractionation 2Nivolumab 2Ifosfamide 2Etoposide 2AZD 6244 2thymoglobulin 1tazemetostat 1sotigalimab 1selinexor 1romidepsin 1perifosine 1pembrolizumab 1pazopanib 1lorvotuzumab mertansine 1fludarabine phosphate 1exatecan 1decitabine and cedazuridine drug combination 1Trabectedin 1Thiotepa 1Temozolomide 1Tacrolimus 1Sunitinib 1Stem Cell Transplantation 1Specimen Handling 1Sirolimus 1Razoxane 1Radiotherapy, Intensity-Modulated 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase 2 × Neurofibrosarcoma × AZD 6244 × Clear all
NCT03433183 2026-05-27

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

Sarcoma Alliance for Research through Collaboration

Phase 2 Completed
21 enrolled 12 charts
CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

NCT05253131 2026-02-11

Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas

University of Alabama at Birmingham

Phase 2 Not yet recruiting
41 enrolled
CNSSarcoma

Neurofibromatosis 1, Sarcoma, Neurofibrosarcoma

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