Clinical Trials Browser

Mouth Neoplasms, Oropharyngeal Neoplasms, Mucositis

NCT03082534 2026-01-28

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Neoplasm Metastasis, Oropharyngeal Neoplasms, Recurrence

NCT03416153 2025-05-22

Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx Cancer

Phase 2 Completed

91 enrolled 11 charts

Head & Neck

Oropharyngeal Neoplasms

NCT03838263 2025-03-04

IMMUNEBOOST

Phase 2 Completed

62 enrolled

Head & Neck

Oropharyngeal Neoplasms

NCT03715946 2025-01-13

Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer

Phase 2 Completed

40 enrolled 69 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT02281955 2025-01-07

De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study

Phase 2 Completed

115 enrolled 18 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT01530997 2024-11-13

De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca

Phase 2 Completed

45 enrolled 22 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT03422536 2024-09-04

Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma

Phase 2 Completed

78 enrolled 16 charts

Head & Neck

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04541355 2024-06-28

Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin

Phase 2 Completed

16 enrolled 12 charts

Head & Neck

Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03077243 2024-05-02

P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC

Phase 2 Completed

195 enrolled 19 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT02784288 2023-06-27

Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer

Phase 2 Completed

40 enrolled 11 charts

Head & Neck

Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT03427411 2023-03-28

M7824 in Subjects With HPV Associated Malignancies

Phase 2 Completed

57 enrolled 20 charts

GastrointestinalGenitourinaryGynecologicHead & Neck

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms

NCT03096808 2021-10-26

Adaptive Radiotherapy for Head and Neck Cancer

Phase 2 Completed

64 enrolled

Head & Neck

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Paranasal Sinus Neoplasms

NCT01173692 2021-08-20

Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study.

Phase 2 Completed

47 enrolled 7 charts

Head & Neck

cyclopia sequence, Oropharyngeal Neoplasms

NCT01440270 2020-05-05

Neo-adjuvant Erbitux-based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer

Phase 2 Completed

145 enrolled

Head & Neck

Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00524017 2020-03-12

Cetuximab in Treating Patients With Precancerous Lesions of the Upper Aerodigestive Tract

Phase 2 Completed

35 enrolled 6 charts

Head & NeckOther neoplasm

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Precancerous Conditions, Salivary Gland Neoplasms

NCT02159703 2019-11-21

A Single-arm Phase II Study of Post-Transoral Robotic Surgery (TORS) Alone to the Primary Tumor Site and Selective Neck Dissection (SND) Followed by Adjuvant Radiation Therapy (+/- Chemotherapy) to the Regional Nodes for Advanced Stage, Human Papilloma Virus (HPV) Positive, Oropharyngeal Cancer

Phase 2 Completed

60 enrolled 9 charts

Head & Neck

Margins of Excision, Oropharyngeal Neoplasms

NCT00721799 2019-08-06

F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients

Phase 2 Completed

33 enrolled 39 charts

Head & Neck

Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00052611 2018-03-29

Celecoxib in Preventing Cancer in Patients With Oral Leukoplakia and/or Head and Neck Dysplasia

Phase 2 Completed

23 enrolled

Head & Neck

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms

NCT01585428 2018-03-07

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers

Phase 2 Completed

29 enrolled 12 charts

GastrointestinalGenitourinaryGynecologicHead & Neck

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Papillomavirus Infections

NCT01435252 2017-11-06

A Phase II Study In Patients With Advanced Head And Neck Cancer Of Standard Chemoradiation And Add-On Cetuximab

Phase 2 Completed

68 enrolled

Head & Neck

Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Oropharyngeal Neoplasms

NCT00376987 2017-05-30

Zinc Supplements in Lowering Cadmium Levels in Smokers

Phase 2 Completed

61 enrolled

GastrointestinalGenitourinaryGynecologicHead & NeckOther hematologic neoplasmThoracic

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Tobacco Use Disorder, Tongue Neoplasms, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma

NCT00534001 2017-05-30

Bupropion in Helping Adults Stop Smoking

Phase 2 Completed

95 enrolled 8 charts

GastrointestinalGenitourinaryGynecologicHead & NeckOther hematologic neoplasmThoracic

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Tobacco Use Disorder, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma

NCT01695122 2016-02-23

Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 2 Completed

14 enrolled

Head & Neck

Head and Neck Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT01733797 2015-10-01

Trismus Trial of Therabite vs Wooden Spatula in Head and Neck Cancer Patients

Phase 2 Completed

71 enrolled

Head & Neck

Head and Neck Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Trismus

NCT01032928 2015-01-01

RSPT

Phase 2 Completed

30 enrolled 9 charts

Head & Neck

Deglutition Disorders, Oropharyngeal Neoplasms, Respiratory Aspiration

NCT00330382 2014-12-19

Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia

Phase 2 Completed

325 enrolled 15 charts

Head & Neck

Leukoplakia, Oral, Mouth Neoplasms, Oropharyngeal Neoplasms, Tongue Neoplasms

NCT00002951 2013-09-05

Chemotherapy Plus Radiation Therapy in Treating Patients With Head and Neck Cancer

Phase 2 Completed

53 enrolled

GastrointestinalHead & Neck

Esophageal Neoplasms, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms

NCT00101335 2013-07-11

Celecoxib in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia

Phase 2 Completed

Head & NeckOther neoplasm

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Leukoplakia, Oral, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Precancerous Conditions, Tongue Neoplasms

NCT00780312 2013-07-02

HOHF

Phase 2 Completed

97 enrolled

Head & Neck

Fibrosis, Lymphedema, Mouth Neoplasms, Oropharyngeal Neoplasms, Radiation Injuries, Trismus

NCT00002964 2013-02-05

Porfimer Sodium in Diagnosing Patients With Head and Neck Cancer

Phase 2 Completed

Head & Neck

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

Clinical Trials

MuciLight

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx Cancer

IMMUNEBOOST

Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer

De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study

De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca

Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma

Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin

P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC

Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer

M7824 in Subjects With HPV Associated Malignancies

Adaptive Radiotherapy for Head and Neck Cancer

Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study.

Neo-adjuvant Erbitux-based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer

Cetuximab in Treating Patients With Precancerous Lesions of the Upper Aerodigestive Tract

A Single-arm Phase II Study of Post-Transoral Robotic Surgery (TORS) Alone to the Primary Tumor Site and Selective Neck Dissection (SND) Followed by Adjuvant Radiation Therapy (+/- Chemotherapy) to the Regional Nodes for Advanced Stage, Human Papilloma Virus (HPV) Positive, Oropharyngeal Cancer

F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients

Celecoxib in Preventing Cancer in Patients With Oral Leukoplakia and/or Head and Neck Dysplasia

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers

A Phase II Study In Patients With Advanced Head And Neck Cancer Of Standard Chemoradiation And Add-On Cetuximab

Zinc Supplements in Lowering Cadmium Levels in Smokers

Bupropion in Helping Adults Stop Smoking

Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

Trismus Trial of Therabite vs Wooden Spatula in Head and Neck Cancer Patients

RSPT

Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia

Chemotherapy Plus Radiation Therapy in Treating Patients With Head and Neck Cancer

Celecoxib in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia

HOHF

Porfimer Sodium in Diagnosing Patients With Head and Neck Cancer