Clinical Trials

Sarcoma, Osteosarcoma

NCT07357519 2026-05-01

Lu-TARGO (177Lu-TARGeted Osteosarcoma Therapy)

Phase 1/2 Recruiting

55 enrolled

Phase 3 Active not recruiting

Osteosarcoma

NCT06935409 2026-04-09

Study of HS-20093 Versus Gemcitabine in Combination With Docetaxel in Treatment of Osteosarcoma After Previous Second-line Treatment Failure

117 enrolled

Osteosarcoma

NCT04833582 2026-04-03

A Study of Azenosertib (ZN-c3) in Combination With Gemcitabine in Subjects With Osteosarcoma

31 enrolled

Osteosarcoma

NCT06341712 2026-03-31

CabOSTar

Phase 2 Terminated

10 enrolled

Phase 1 Active not recruiting

Osteosarcoma

NCT03478462 2026-03-18

CLOVER-2

30 enrolled

CNSGenitourinaryLymphoidSarcoma

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioblastoma, Glioma, Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Gliosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT05199584 2026-03-05

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

CNSDermatologicEndocrineHead & NeckOther solid neoplasmSarcomaThoracic

Uveal Melanoma, Glioma, Adenoma, Islet Cell, Laryngeal Diseases, Medulloblastoma, Melanoma, Mesothelioma, Neuroblastoma, Pituitary Diseases, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma

NCT04238819 2026-03-02

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma

47 enrolled 36 charts

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT05642455 2026-02-09

SPEARHEAD-3 Pediatric Study

Phase 1/2 Recruiting

Neuroblastoma, Osteosarcoma, Sarcoma, Synovial, Neurofibrosarcoma

NCT06387485 2026-02-06

A Study to Evaluate the Utilization of 3D Printed Models in Pre-Operative Planning

Phase NA Recruiting

150 enrolled

Chondrosarcoma, Fibrosarcoma, Sarcoma, Ewing, Osteosarcoma, Histiocytoma, Benign Fibrous

NCT04544995 2026-01-21

Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors (SCOOP)

47 enrolled 43 charts

Phase EARLY_PHASE1 Recruiting

Neoplasms, Neuroblastoma, Osteosarcoma

NCT06645808 2025-12-29

VARTUTRACE

32 enrolled

BreastCNSGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Chondrosarcoma, Colonic Neoplasms, Esophageal Neoplasms, Glioblastoma, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Sarcoma, Osteosarcoma, Stomach Neoplasms

NCT06438783 2025-12-12

TQB2928 Injection Combined Anlotinib Hydrochloride Capsule in Recurrent/Metastatic Osteosarcoma and Other Solid Tumors

Phase 1/2 Active not recruiting

Osteosarcoma

NCT06521567 2025-11-12

A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

83 enrolled

CNSDermatologicGastrointestinalLymphoidSarcoma

Fibrolamellar hepatocellular carcinoma, Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioblastoma, Carcinoma, Hepatocellular, Hodgkin Disease, Melanoma, Rhabdomyosarcoma, Osteosarcoma, Hepatoblastoma

NCT05958199 2025-06-27

A Study of NPX267 for Subjects With Solid Tumors Known to Express HHLA2/B7-H7

Phase 1 Suspended

131 enrolled

BreastGastrointestinalGenitourinaryGynecologicSarcomaThoracic

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Osteosarcoma, Colorectal Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma, Triple Negative Breast Neoplasms

NCT05588648 2025-04-10

Study to Assess Safety and Efficacy of Vactosertib in Adolescents and Adults With Recurrent, Refractory or Progressive Osteosarcoma

Phase 1/2 Recruiting

48 enrolled

Phase 2 Active not recruiting

Osteosarcoma

NCT04974008 2025-01-22

OST-164-01

39 enrolled

Phase 1 Not yet recruiting

Bone Neoplasms, Osteosarcoma

NCT06699576 2024-11-21

ARTEMIS-103: Phase 1b Study of HS-20093 Combinations in Patients with Bone and Soft Tissue Sarcoma.

448 enrolled

Sarcoma, Osteosarcoma

NCT05830123 2024-08-23

ARTEMIS-002: HS-20093 in Patients With Relapsed or Refractory Osteosarcoma and Other Sarcomas

Phase 2 Recruiting

170 enrolled

Sarcoma, Osteosarcoma

NCT04154189 2024-07-22

A Study to Compare the Efficacy and Safety of Ifosfamide and Etoposide With or Without Lenvatinib in Children, Adolescents and Young Adults With Relapsed and Refractory Osteosarcoma

81 enrolled 22 charts

Recurrence, Osteosarcoma

NCT05093322 2024-06-07

A Study of Surufatinib in Combination With Gemcitabine in Pediatric, Adolescent, and Young Adult Patients With Recurrent or Refractory Solid Tumors

Phase 1 Not yet recruiting

13 enrolled 17 charts

LymphoidSarcoma

Lymphoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma

NCT06412458 2024-05-14

IM83 Clinical Study of CAR-T Cell Therapy in Patients With Relapsed or Refractory Osteosarcoma

9 enrolled

BreastDermatologicGastrointestinalGynecologicSarcomaThoracic

Recurrence, Osteosarcoma

NCT04282044 2024-02-08

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

Phase 1 Recruiting

60 enrolled

Carcinoma, Ovarian Epithelial, Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Melanoma, Osteosarcoma, Stomach Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT03422679 2024-01-16

Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies

Phase 1/2 Terminated

79 enrolled 22 charts

BreastGastrointestinalLymphoidOther hematologic neoplasmSarcoma

Breast Neoplasms, Carcinoma, Adenoid Cystic, Glomus Tumor, Carcinoma, Hepatocellular, Lymphoma, Non-Hodgkin, Osteosarcoma, Colorectal Neoplasms, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT00089245 2023-12-26

Radiolabeled MAB Therapy in Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer

177 enrolled

Phase EARLY_PHASE1 Recruiting

Brain Neoplasms, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Meningeal Carcinomatosis, Desmoplastic Small Round Cell Tumor

NCT06171282 2023-12-14

A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Advanced Bone and Soft Tissue Tumors

9 enrolled

Phase EARLY_PHASE1 Unknown

Bone Neoplasms, Sarcoma, Osteosarcoma

NCT03458728 2023-12-04

Safety, Tolerability, Efficacy and Pharmacokinetics of Copanlisib in Pediatric Patients

Phase 1/2 Terminated

31 enrolled 17 charts

CNSLymphoidSarcoma

Lymphoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT06117878 2023-11-07

Safety and Efficacy of NK510 to Treat Osteosarcoma and Soft Tissue Sarcoma

12 enrolled

Sarcoma, Osteosarcoma

NCT03860207 2023-09-13

Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3F8-BsAb) in Patients With Relapsed/Refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers

Phase 1/2 Terminated

12 enrolled 15 charts

Neuroblastoma, Osteosarcoma

NCT02432274 2023-07-11

Study of Lenvatinib in Children and Adolescents With Refractory or Relapsed Solid Malignancies and Young Adults With Osteosarcoma

117 enrolled 32 charts

Phase EARLY_PHASE1 Unknown

Neoplasms, Osteosarcoma

NCT05851456 2023-05-09

A Clinical Study on Oncolytic Virus Injection (R130) for the Treatment of Relapsed/Refractory Bone and Soft Tissue Tumors

Bone Neoplasms, Sarcoma, Osteosarcoma

NCT04861948 2022-10-04

IBI188 Combination Therapy in Solid Tumors

9 enrolled

SarcomaThoracic

Adenocarcinoma of Lung, Osteosarcoma

NCT02982941 2022-02-08

Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors

25 enrolled

CNSGenitourinarySarcoma

Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Desmoplastic Small Round Cell Tumor

NCT04886765 2021-05-14

A Study to Evaluate the Safety and Efficacy of ALMB-0168 in Patients With Osteosarcoma

Phase 1/2 Unknown

238 enrolled

Phase EARLY_PHASE1 Unknown

Osteosarcoma

NCT04864821 2021-05-06

Clinical Study of CD276 Targeted Autologous Chimeric Antigen Receptor T Cell Infusion in Patients With CD276 Positive Advanced Solid Tumor

24 enrolled

CNSGastrointestinalSarcomaThoracic

Lung Neoplasms, Neuroblastoma, Osteosarcoma, Stomach Neoplasms

NCT01759303 2021-04-13

Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung

Phase 2 Terminated

12 enrolled

Osteosarcoma

NCT01987102 2020-09-25

Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX.

18 enrolled 20 charts

Osteosarcoma

NCT02223052 2020-05-12

Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies

BreastCNSDermatologicGenitourinaryGynecologicHead & NeckLymphoidMyeloidOther hematologic neoplasmPlasma cellSarcomaThoracic

89 enrolled

Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Glioblastoma, Hodgkin Disease, Kidney Neoplasms, Leukemia, Lung Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, Melanoma, Multiple Myeloma, Myelodysplastic Syndromes, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Sarcoma, Osteosarcoma, Skin Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Small Cell Lung Carcinoma

NCT01962103 2019-12-27

Study to Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors

107 enrolled 42 charts

CNSDermatologicSarcoma

Fibrosarcoma, Melanoma, Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Dermatofibrosarcoma, Histiocytoma

NCT01650090 2019-08-07

Phase 2 Study of Inhaled Lipid Cisplatin in Pulmonary Recurrent Osteosarcoma

28 enrolled

Osteosarcoma

NCT03676985 2018-09-26

A Clinical Study of PD-L1 Antibody ZKAB001(Drug Code) in Limited Stage of High-grade Osteosarcoma

Phase 1/2 Unknown

15 enrolled

Osteosarcoma

NCT00617890 2018-08-23

A Study to Determine the Activity of Robatumumab (SCH 717454) in Participants With Relapsed Osteosarcoma or Ewing's Sarcoma (MK-7454-002/P04720)

Phase 2 Terminated

219 enrolled 13 charts

Sarcoma, Ewing, Osteosarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00102531 2017-08-01

Inhalation SLIT Cisplatin (Liposomal) for the Treatment of Osteosarcoma Metastatic to the Lung

19 enrolled 8 charts

Neoplasm Metastasis, Recurrence, Osteosarcoma

NCT00154388 2016-11-18

Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases

BreastDermatologicGenitourinaryGynecologicLymphoidMyeloidOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

185 enrolled

Malignant mesenchymal tumor, Adenocarcinoma, Brenner Tumor, Carcinoma, Renal Cell, Chondrosarcoma, Chordoma, Carcinoma, Adenoid Cystic, Fibroma, Hemangiopericytoma, Hemangiosarcoma, Leiomyosarcoma, Leukemia, Mast-Cell, Liposarcoma, Mastocytosis, Melanoma, Mesothelioma, Multiple Myeloma, Pleural Neoplasms, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Thymoma, Hypereosinophilic Syndrome, Sarcoma, Endometrial Stromal, Dermatofibrosarcoma, Rhabdomyosarcoma, Embryonal, Seminoma, Carcinoma, Ductal, Breast, Neurofibrosarcoma, Primary Myelofibrosis, Small Cell Lung Carcinoma

NCT01169584 2016-01-21

Safety Study of Recombinant Vaccinia Virus to Treat Refractory Solid Tumors in Pediatric Patients

CNSGenitourinaryLymphoidSarcoma

6 enrolled

Lymphoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Vaccinia, Neurofibrosarcoma

NCT00413075 2015-07-08

Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma

BreastGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmSarcomaThoracic

121 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Chondrosarcoma, Esophageal Neoplasms, Fibrosarcoma, Head and Neck Neoplasms, Hemangiosarcoma, Hodgkin Disease, Kidney Neoplasms, Leiomyosarcoma, Liposarcoma, Lung Neoplasms, Lymphoma, Mesothelioma, Otorhinolaryngologic Neoplasms, Ovarian Neoplasms, Parathyroid Neoplasms, Prostatic Neoplasms, Sarcoma, Osteosarcoma, Thyroid Neoplasms, Colorectal Neoplasms, Lymphoma, B-Cell, Lymphoma, T-Cell, Adenosarcoma, Mixed Tumor, Mesodermal, Mesothelioma, Cystic, Carcinoma, Small Cell

NCT00413322 2015-07-08

Study of PXD101 Alone and in Combination With 5-Fluorouracil (5-FU) in Patients With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

35 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Carcinosarcoma, Chondrosarcoma, Solitary Pulmonary Nodule, Phyllodes Tumor, Esophageal Neoplasms, Facial Neoplasms, Fibrosarcoma, Head and Neck Neoplasms, Hemangiosarcoma, Kidney Neoplasms, Leiomyosarcoma, Liposarcoma, Lung Neoplasms, Lymphangiosarcoma, Mesothelioma, Mouth Neoplasms, Myosarcoma, Myxosarcoma, Neoplasms, Otorhinolaryngologic Neoplasms, Ovarian Neoplasms, Pancoast Syndrome, Parathyroid Neoplasms, Sarcoma, Osteosarcoma, Thyroid Neoplasms, Tracheal Neoplasms, Colorectal Neoplasms, Adenosarcoma, Mixed Tumor, Mesodermal, Mesothelioma, Cystic, Carcinoma, Small Cell, Pulmonary Sclerosing Hemangioma, Histiocytoma, Malignant Fibrous

NCT00093080 2015-02-13

Study of AP23573/MK-8669 (Ridaforolimus), A Mammalian Target of Rapamycin (mTOR) Inhibitor, in Participants With Advanced Sarcoma (MK-8669-018 AM1)(COMPLETED)

216 enrolled

Leiomyosarcoma, Liposarcoma, Neoplasm Metastasis, Sarcoma, Osteosarcoma

NCT00503295 2014-10-02

Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lung

53 enrolled