Announcements Trials
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Phase

Phase 3 2Phase EARLY_PHASE1 1Phase 1 1

Status

Completed 3Suspended 1

Sponsor Class

OTHER 2NETWORK 1INDUSTRY 1

Study Type

Interventional 4

Sponsor

Cancer Type

Gastrointestinal 3Sarcoma 1Gynecologic 1Genitourinary 1CNS 1

Conditions

Mesothelioma, Malignant 5Hepatoblastoma 5Ototoxicity 4Medulloblastoma 4Central Nervous System Neoplasms 4Peritoneal Neoplasms 3Ovarian Neoplasms 3Hearing Loss 3Gastrointestinal Neoplasms 3Drug-Related Side Effects and Adverse Reactions 3Testicular Neoplasms 2Stomach Neoplasms 2Sarcoma 2Oligodendroglioma 2Neoplasms, Germ Cell and Embryonal 2Liver Neoplasms 2Glioma 2Brain Neoplasms 2Astrocytoma 2Adrenocortical Carcinoma 2Thrombocytopenia 1Teratoma 1Seminoma 1Rhabdomyosarcoma 1Rectal Neoplasms 1Pelvic Neoplasms 1Ovarian Germ Cell Cancer 1Osteosarcoma 1Oropharyngeal Neoplasms 1Optic Nerve Glioma 1

Interventions

sodium thiosulfate 4Cisplatin 4Methotrexate 2Chemotherapy, Adjuvant 2Acetylcysteine 2tempol 1ebselen 1Vorinostat 1Vincristine 1Thioctic Acid 1Surveys and Questionnaires 1Sodium Chloride 1Restraint, Physical 1Radiotherapy, Intensity-Modulated 1Radiotherapy, Conformal 1Radiotherapy 1Radiosurgery 1Pantoprazole 1Mental Status and Dementia Tests 1Magnetic Resonance Spectroscopy 1Hydroxymethylglutaryl-CoA Reductase Inhibitors 1Hyaluronic Acid 1Hearing Tests 1Genetic Association Studies 1Drug Therapy 1Dexamethasone 1Cyclophosphamide 1Chemoradiotherapy 1Carboplatin 1Audiometry 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Ototoxicity × sodium thiosulfate × Clear all
NCT05756660 2025-10-20

Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy

Children's Hospital Medical Center, Cincinnati

Phase EARLY_PHASE1 Suspended
33 enrolled
Gastrointestinal

Ototoxicity, Neoplasms, Germ Cell and Embryonal, Hepatoblastoma

NCT00716976 2023-11-09

Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy

Children's Oncology Group

Phase 3 Completed
131 enrolled 18 charts 1 FDA
CNSGastrointestinalGenitourinaryGynecologicSarcoma

Ovarian Germ Cell Cancer, Ototoxicity, Brain Neoplasms, Liver Neoplasms, Medulloblastoma, Neuroblastoma, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Hepatoblastoma

NCT04262336 2023-07-06

Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment

Decibel Therapeutics

Phase 1 Completed
22 enrolled

Ototoxicity, Hearing Loss

NCT00652132 2018-05-29

SIOPEL6

University of Birmingham

Phase 3 Completed
116 enrolled 1 FDA
Gastrointestinal

Ototoxicity, Liver Neoplasms, Hepatoblastoma

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