Clinical Trials

Phase 2 Active not recruiting

Ependymoma, Medulloblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT02574728 2026-03-02

AflacST1502

46 enrolled

CNSMyeloidSarcoma

Brain Neoplasms, Carcinoma, Ependymoma, Histiocytosis, Langerhans-Cell, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT06942039 2026-02-27

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

Phase EARLY_PHASE1 Recruiting

15 enrolled

Phase 1 Not yet recruiting

Medulloblastoma, Neuroblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT07390539 2026-02-05

B7-H3.CD28Z.CART in CNS Neoplasms

70 enrolled

Brain Neoplasms, Ependymoma, Medulloblastoma, Meningeal Neoplasms, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT07087002 2026-01-27

GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults

Phase 1 Recruiting

18 enrolled

Phase 1 Active not recruiting

Brain Neoplasms, Medulloblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03500991 2025-12-17

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

10 enrolled

Choroid Plexus Carcinoma, Brain Neoplasms, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor

NCT03638167 2025-12-17

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

11 enrolled

NCT01063114 2025-08-13

Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma

Phase NA Completed

90 enrolled 11 charts

Brain Neoplasms, Medulloblastoma, Pinealoma

NCT04743310 2025-06-13

Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System

50 enrolled

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Neuroma, Acoustic, Pinealoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT03990597 2024-10-09

StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord

Phase 1 Withdrawn

Phase NA Not yet recruiting

Ependymoma, Glioma, Medulloblastoma, Pinealoma, Central Nervous System Neoplasms

NCT06516471 2024-07-24

The Evolution of Neuroendoscopy Guided by Head-mounted Mixed Reality Technique Navigation System in Neurosurgery

40 enrolled

Pinealoma, Brain Stem Neoplasms

NCT03434262 2024-05-31

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

68 enrolled

CNSLymphoid

Choroid Plexus Carcinoma, Microphthalmia, Isolated, with Coloboma 5, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Lymphoma, Follicular, Medulloblastoma, Meningioma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pinealoma, Recurrence, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Rhabdoid Tumor, Pyloric Stenosis, Hypertrophic

NCT00369785 2021-10-20

Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors

Phase 3 Completed

198 enrolled 10 charts

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Fatigue, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasm Metastasis, Oligodendroglioma, Pinealoma, Radiation Injuries, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT00070161 2021-09-09

Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor

68 enrolled

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Radiation Injuries, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT02596828 2021-08-05

Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma

4 enrolled

Pinealoma

NCT01024907 2020-12-10

Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas

Phase 1/2 Completed

23 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioma, Oligodendroglioma, Pinealoma

NCT00179803 2020-08-05

Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors

24 enrolled

Phase EARLY_PHASE1 Completed

Astrocytoma, Brain Neoplasms, Glioblastoma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Supratentorial Neoplasms, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT03885258 2019-03-21

Melatonin Replacement Therapy in Pinealectomized Patients

5 enrolled

Pinealoma

NCT01977677 2018-10-23

Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma

Phase 1/2 Completed

30 enrolled 11 charts

Glioblastoma, Glioma, Medulloblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT01234805 2018-07-03

Yoga Therapy in Treating Patients With Malignant Brain Tumors

Phase NA Terminated

9 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT00784914 2018-04-17

A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors

12 enrolled

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasm Metastasis, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT02194452 2017-04-28

Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors

Phase NA Withdrawn

Familial ependymoma, Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neuroma, Acoustic, Oligodendroglioma, Pinealoma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Optic Nerve Glioma

NCT00253721 2017-04-21

Melphalan With BBBD in Treating Patients With Brain Malignancies

Phase 1 Terminated

21 enrolled

CNSLymphoid

Astrocytoma, Brain Neoplasms, Glioma, Lymphoma, Medulloblastoma, Neoplasm Metastasis, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms

NCT02967380 2017-03-27

Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases

Phase NA Terminated

14 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Multiple Sclerosis, Oligodendroglioma, Pinealoma, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT00003484 2015-04-23

Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors

21 enrolled

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neuroblastoma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00003461 2014-08-21

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors

Phase 1/2 Completed

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00008086 2013-12-19

Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT00629889 2013-05-22

Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors

52 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Seizures, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT00544284 2013-02-15

Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment

25 enrolled

CNSLymphoidSarcoma

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Lymphoma, Medulloblastoma, Meningioma, Neoplasm Metastasis, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT00005790 2012-06-11

Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors

Phase NA Withdrawn

Astrocytoma, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT00025558 2011-03-28

Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer

Familial ependymoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00049296 2010-06-11

Thalidomide and Docetaxel in Treating Patients With Advanced Cancer