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Phase

Phase 2 1

Status

Suspended 1

Sponsor Class

NIH 1

Study Type

Interventional 1

Sponsor

Cancer Type

Myeloid 1

Conditions

Multiple Myeloma 14Leukemia, Myeloid, Acute 13Lymphoma 12Neoplasm Metastasis 11Pancreatic Neoplasms 9Prostatic Neoplasms 8Myelodysplastic Syndromes 8Burkitt Lymphoma 8Breast Neoplasms 8Glioma 7Colorectal Neoplasms 7Sarcoma 6Leukemia, Lymphocytic, Chronic, B-Cell 6Triple Negative Breast Neoplasms 5Precursor Cell Lymphoblastic Leukemia-Lymphoma 5Neuroblastoma 5Lymphoma, T-Cell 5Lymphoma, Non-Hodgkin 5Central Nervous System Neoplasms 5Carcinoma, Renal Cell 5Wilms Tumor 4Squamous Cell Carcinoma of Head and Neck 4Rhabdoid Tumor 4Ovarian Neoplasms 4Oropharyngeal Neoplasms 4Neuroectodermal Tumors, Primitive, Peripheral 4Medulloblastoma 4Lung Neoplasms 4Histiocytosis, Langerhans-Cell 4Hepatoblastoma 4

Interventions

ruxolitinib 2umbralisib 1iadademstat 1fludarabine phosphate 1decitabine and cedazuridine drug combination 1Whole-Body Irradiation 1Tacrolimus 1Specimen Handling 1Sirolimus 1Peripheral Blood Stem Cell Transplantation 1Panobinostat 1Mycophenolic Acid 1Methotrexate 1Melphalan 1Etoposide 1Cyclosporine 1Cyclophosphamide 1Busulfan 1Biopsy 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Polycythemia Vera × Biopsy × 30 days × Clear all
NCT06661915 2026-05-29

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

National Cancer Institute (NCI)

Phase 2 Suspended
62 enrolled
Myeloid

Myeloproliferative Disorders, Polycythemia Vera, Thrombocythemia, Essential, Myelodysplastic-Myeloproliferative Diseases, Primary Myelofibrosis

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