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Phase

Phase 1 1

Status

Recruiting 1

Sponsor Class

NIH 1

Study Type

Interventional 1

Sponsor

Cancer Type

Plasma cell 1Other hematologic neoplasm 1Myeloid 1Lymphoid 1

Conditions

Melanoma 15Neoplasm Metastasis 11Ovarian Neoplasms 9Pancreatic Neoplasms 8Carcinoma, Non-Small-Cell Lung 8Stomach Neoplasms 6Skin Neoplasms 6Leukemia, Myeloid, Acute 6Colorectal Neoplasms 6Carcinoma, Renal Cell 6Triple Negative Breast Neoplasms 4Gastrointestinal Neoplasms 4Breast Neoplasms 4Vulvar Neoplasms 3Uterine Cervical Neoplasms 3Urogenital Neoplasms 3Rectal Neoplasms 3Neuroblastoma 3Myelodysplastic Syndromes 3Multiple Myeloma 3Leukemia 3Colonic Neoplasms 3Vaginal Neoplasms 2Squamous Cell Carcinoma of Head and Neck 2Sarcoma 2Precursor Cell Lymphoblastic Leukemia-Lymphoma 2Pleural Effusion, Malignant 2Penile Neoplasms 2Oropharyngeal Neoplasms 2Neoplasms 2

Interventions

Cyclophosphamide 23Dexamethasone 16Cytarabine 15Vincristine 14venetoclax 13Methotrexate 11Etoposide 10Doxorubicin 10Calcium Dobesilate 10dexamethasone acetate 9dexamethasone 21-phosphate 9auricularum 9Prednisone 9prednylidene 8merphos 8deltacortene 8Specimen Handling 8calaspargase pegol 7Mercaptopurine 7pegaspargase 6fludarabine phosphate 6Granulocyte Colony-Stimulating Factor 6Daunorubicin 6Biopsy 6Asparaginase 6fludarabine 5daratumumab 5azathiopurine 5Thioguanine 5Stem Cell Transplantation 5

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

1 trials
RecentStart dateEnrollment
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma × aldesleukin × 1 year × Clear all
NCT06904066 2026-06-15

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

National Institutes of Health Clinical Center (CC)

Phase 1 Recruiting
86 enrolled
LymphoidMyeloidOther hematologic neoplasmPlasma cell

Multiple Myeloma, Myelodysplastic Syndromes, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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