Clinical Trials

9,500 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT05308446 2026-06-03

Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

86 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT06577194 2026-06-03

A Single-Center, Single-Arm Study of Neoadjuvant Short-Course Radiotherapy Followed by Sequential Immunotherapy With CAPOX Combined With PD-1 Antibody and IL-2 for Locally Advanced Rectal Cancer

35 enrolled

Phase 2 Not yet recruiting

Rectal Neoplasms

NCT07622771 2026-06-03

Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized, Phase II Clinical Trial

84 enrolled

Rectal Neoplasms

NCT04643366 2026-06-02

Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer

54 enrolled

Phase NA Active not recruiting

Rectal Neoplasms

NCT05007015 2026-06-02

TAI-LARS

66 enrolled

Phase NA Active not recruiting

Low Anterior Resection Syndrome, Rectal Neoplasms

NCT05056077 2026-06-02

TTBF

353 enrolled

BreastGastrointestinalGenitourinaryGynecologic

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Colonic Neoplasms, Kidney Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT06637462 2026-06-02

A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer

60 enrolled

Rectal Neoplasms

NCT07619768 2026-06-02

Self Regulation Hypnotic Intervention for Pain and Anxiety During Rectal Brachytherapy

Phase NA Completed

52 enrolled

Phase 2 Not yet recruiting

Rectal Neoplasms

NCT07622017 2026-06-02

K-BOOST

24 enrolled

Rectal Neoplasms

NCT06607458 2026-06-01

DEL-LIVER

90 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT07616297 2026-06-01

REBOOT

25 enrolled

Rectal Neoplasms

NCT03190941 2026-05-29

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Phase 1/2 Recruiting

110 enrolled

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04751370 2026-05-29

Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer

31 enrolled

Rectal Neoplasms

NCT06997497 2026-05-29

KANDLELIT-012

Phase 3 Recruiting

477 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT07341126 2026-05-29

R-ALERT

Not yet recruiting

30 enrolled

Phase 1 Active not recruiting

Intestinal Neoplasms, Rectal Neoplasms

NCT02403505 2026-05-28

CEA+RC-BCG

20 enrolled

Phase 1/2 Not yet recruiting

Rectal Neoplasms

NCT07610798 2026-05-28

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-8989 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutations

178 enrolled

GastrointestinalGynecologic

Biliary Tract Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT07595874 2026-05-27

NEST3

Phase 2 Not yet recruiting

100 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT05723562 2026-05-26

AZUR-1

154 enrolled

GastrointestinalGynecologicOther solid neoplasmThoracic

Rectal Neoplasms

NCT06051695 2026-05-26

EVEREST-2

Phase 1/2 Recruiting

474 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Recurrence, Colorectal Neoplasms

NCT06337552 2026-05-26

High-Fermented Food Intervention Among Locally Advanced Rectal Cancer Patients (The FEED Trial)

Phase NA Active not recruiting

39 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Rectal Neoplasms

NCT06607185 2026-05-26

A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

Phase 1 Active not recruiting

750 enrolled

GastrointestinalGynecologicThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Esophageal Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma

NCT07176182 2026-05-26

Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression

236 enrolled

Rectal Neoplasms

NCT07605611 2026-05-26

SC-Stoma

72 enrolled

Rectal Neoplasms, Anastomotic Leak

NCT03068403 2026-05-22

RECT

Phase NA Completed

2 enrolled

Rectal Neoplasms

NCT03548961 2026-05-22

Organ Preservation in Early Rectal Cancer Patients

19 enrolled

Phase 1/2 Active not recruiting

Rectal Neoplasms

NCT04017650 2026-05-22

Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer

38 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Disease Progression

NCT04503694 2026-05-22

REGINA

72 enrolled

Rectal Neoplasms

NCT06263088 2026-05-22

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

EndocrineGastrointestinalNET

200 enrolled

Anus Neoplasms, Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Neuroendocrine Tumors

NCT06704724 2026-05-22

A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene.

Phase 1 Terminated

30 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal

NCT06802172 2026-05-22

Effect of Meal Timing During Cancer Treatment in Patients in Alaska: A Randomized Clinical Trial

Phase EARLY_PHASE1 Recruiting

100 enrolled

BreastGastrointestinal

Intermittent Fasting, Breast Neoplasms, Rectal Neoplasms

NCT03594630 2026-05-20

Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer

120 enrolled

Rectal Neoplasms

NCT03745326 2026-05-19

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

Phase 1/2 Terminated

5 enrolled 14 charts

Phase 1/2 Active not recruiting

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT05726864 2026-05-19

AMPLIFY-7P

158 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07594925 2026-05-19

Short-Course Radiotherapy Followed by Immunotherapy Combined With Chemotherapy for Microsatellite Stable Locally Advanced Rectal Cancer: A Prospective, Randomized, Controlled Phase II Clinical Trial

130 enrolled

Rectal Neoplasms

NCT07595107 2026-05-19

Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal Cancer

Not yet recruiting

180 enrolled

Phase NA Not yet recruiting

Rectal Neoplasms

NCT07596732 2026-05-19

SUNRISE

120 enrolled

GastrointestinalThoracic

Colonic Neoplasms, Disease, Esophageal Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04432597 2026-05-18

HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers

Phase 1/2 Active not recruiting

39 enrolled

GastrointestinalGynecologicHead & Neck

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Rectal Neoplasms

NCT06668402 2026-05-18

STEP-R

Completed

120 enrolled

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Motor Activity, Rectal Neoplasms

NCT06904365 2026-05-18

OvAR-Y

Active not recruiting

10 enrolled

Anus Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Rectal Neoplasms, Sarcoma, Stomach Neoplasms, Uterine Neoplasms

NCT03516942 2026-05-15

Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment

Active not recruiting

565 enrolled 16 charts