Clinical Trials

40 enrolled

Anus Neoplasms, Rectal Neoplasms, HIV Infections

NCT06417476 2026-04-13

Short-course Radiotherapy or Long-course Chemoradiation Followed by mFOLFOXIRI Consolidation Chemotherapy for Organ Preservation in Low Rectal Cancer

66 enrolled

Rectal Neoplasms

NCT07011576 2026-03-18

FRUITFUL

60 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07176182 2026-02-27

Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression

236 enrolled

Rectal Neoplasms

NCT00556413 2026-02-05

Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

42 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04165772 2026-01-23

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

200 enrolled

Rectal Neoplasms

NCT05009069 2026-01-22

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

58 enrolled

Rectal Neoplasms

NCT00335816 2026-01-14

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

248 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT02921256 2025-12-04

Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer

363 enrolled 16 charts

Rectal Neoplasms

NCT05358704 2025-12-04

Preoperative ChemoRadiation And FOLFOXIRI for Rectal Cancer (CRAFTER) for Rectal Cancer

Phase 2 Suspended

38 enrolled

Rectal Neoplasms

NCT05610163 2025-09-08

JANUS

783 enrolled

GastrointestinalGynecologic

Rectal Neoplasms

NCT00766142 2025-08-29

COCHISE

Phase 2 Terminated

18 enrolled 9 charts

Colonic Neoplasms, Peritoneal Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02008656 2025-08-27

Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management

358 enrolled

Rectal Neoplasms

NCT00492999 2025-08-17

Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

64 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT04864067 2025-07-01

NOAHS-ARC

73 enrolled

Adenocarcinoma, Rectal Neoplasms

NCT06780787 2025-06-26

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

26 enrolled

Rectal Neoplasms

NCT01652196 2025-02-05

Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer

56 enrolled 14 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01814501 2025-02-05

Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab

16 enrolled 11 charts

Colonic Neoplasms, Rectal Neoplasms

NCT06665087 2024-10-30

CGA Guided Ultrafractionated RT and First-line Systemic Treatment in Elderly or Frail Patients with MCRC

110 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT06652412 2024-10-28

CGA Guided Ultrafractionated RT and Systemic Treatment in Elderly or Frail Patients with Inoperable Localized CRC

124 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT00807911 2024-10-23

Adjuvant Chemotherapy After Preoperative Chemoradiotherapy to Treat Rectal Cancer

322 enrolled 20 charts

Rectal Neoplasms

NCT05628038 2024-10-01

TORCH-R

93 enrolled

Rectal Neoplasms

NCT03698461 2024-01-31

CLIMB

20 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT02363374 2023-12-04

CAOAROAIO-12

311 enrolled

Rectal Neoplasms

NCT02017704 2023-10-17

CORRECT

9 enrolled 9 charts

Rectal Neoplasms

NCT00098787 2023-07-05

Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer

247 enrolled 10 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05868317 2023-05-22

Induction Chemotherapy Followed by Short Course Radiotherapy in Rectal Cancer

Phase 2 Unknown

70 enrolled

Rectal Neoplasms

NCT03299660 2023-03-16

Avelumab With Chemoradiation in Locally Advanced Rectal Cancer

37 enrolled

Rectal Neoplasms

NCT03043729 2023-02-06

mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer

119 enrolled

Rectal Neoplasms

NCT05640726 2022-12-07

The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard Therapy

30 enrolled

Rectal Neoplasms

NCT00467142 2022-11-01

OMEGA

62 enrolled 6 charts

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00936832 2022-08-30

Sunitinib Malate and Combination Chemotherapy as Front-Line Therapy in Treating Patients With Metastatic Rectal Cancer That Cannot Be Removed by Surgery

Phase 2 Withdrawn

Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT01871571 2022-08-09

Bevacizumab, Fluorouracil, Leucovorin Calcium, and Oxaliplatin Before Surgery in Treating Patients With Stage II-III Rectal Cancer

Phase 2 Unknown

17 enrolled

Rectal Neoplasms

NCT03000374 2022-03-17

PIER

34 enrolled

Rectal Neoplasms

NCT00308516 2021-12-10

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

66 enrolled 6 charts

Rectal Neoplasms, Colorectal Neoplasms

NCT04418895 2021-11-10

Neoadjuvant Therapy for Localized Rectal Adenocarcinoma

Phase 2 Withdrawn

Rectal Neoplasms

NCT02319304 2021-11-04

GCC 1314

Phase 2 Terminated

3 enrolled 8 charts

Rectal Neoplasms

NCT00640081 2021-09-22

Combination Chemotherapy and Cetuximab as First-Line Therapy in Treating Patients With Advanced and/or Metastatic Colorectal Cancer

169 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02340949 2021-05-03

RIA

180 enrolled 15 charts

Rectal Neoplasms

NCT02217020 2021-04-14

FORTUNE

100 enrolled

Rectal Neoplasms

NCT03484221 2021-04-14

Totally Neoadjuvant FOLFOXIRI + Short-course Radiation + XELOX in Patients With Locally Advanced Rectal Cancer

Phase 2 Unknown

30 enrolled

Rectal Neoplasms

NCT00066274 2021-03-02

Comparison of Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02641691 2021-02-18

NORMAL-R

20 enrolled 11 charts

Rectal Neoplasms

NCT00005944 2021-02-17

Second-look Surgery With or Without Intraperitoneal Chemotherapy in Treating Patients With Recurrent Colorectal Cancer

Phase 2 Terminated

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00006050 2021-02-17

Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00423696 2021-02-17

Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

145 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01481545 2021-02-03

BRANCH

62 enrolled 13 charts

Rectal Neoplasms

NCT00628810 2020-11-09

Combination Chemotherapy and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

86 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00006366 2020-10-22

Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum