Clinical Trials Browser

Interventional × Rectal Neoplasms × Radiation × Clear all

NCT06205485 2026-05-12

NEO-RT

Phase 3 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07580339 2026-05-12

Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT04751370 2026-05-01

Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT05358704 2025-12-04

Preoperative ChemoRadiation And FOLFOXIRI for Rectal Cancer (CRAFTER) for Rectal Cancer

Phase 2 Suspended

Gastrointestinal

Rectal Neoplasms

NCT06834126 2025-07-18

Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

Phase 1 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06780787 2025-06-26

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04406857 2025-02-26

Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer

Phase 1 Terminated

1 enrolled 7 charts

Gastrointestinal

Rectal Neoplasms

NCT06751394 2024-12-27

TRACER

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT05628038 2024-10-01

TORCH-R

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06455124 2024-06-13

Short-course Radiotherapy Combined With CapeOx and PD-1 Inhibitor After Local Excision for High-risk Early Rectal Cancer (TORCH-LE)

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT03300544 2024-05-23

Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer

Phase 1 Terminated

3 enrolled 9 charts

Gastrointestinal

Rectal Neoplasms

NCT05228431 2024-04-22

Modified Sandwich Therapeutic Regimen for Locally Advanced Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT01769222 2024-01-24

Ipilimumab and Local Radiation for Selected Solid Tumors

Phase 1 Terminated

3 enrolled 5 charts

DermatologicGastrointestinalLymphoidOther hematologic neoplasm

Burkitt Lymphoma, Colonic Neoplasms, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Melanoma, Mycosis Fungoides, Rectal Neoplasms, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Peripheral, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Intraocular Lymphoma

NCT00745134 2023-09-28

Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer

Phase 2 Terminated

22 enrolled 16 charts

Gastrointestinal

Rectal Neoplasms

NCT01740648 2023-09-18

Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer

Phase 1 Completed

Gastrointestinal

Rectal Neoplasms

NCT05939661 2023-07-11

AMBITION

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT02288195 2023-05-12

CONVERT: Neoadjuvant Chemotherapy Alone Versus Preoperative Chemoradiation for Locally Advanced Rectal Cancer Patients

Phase 3 Unknown

Gastrointestinal

Rectal Neoplasms

NCT03297710 2023-01-05

TAS-102 and Radiation Therapy in Treating Patients With Rectal Cancer That Is Locally Recurrent, Metastatic, or Cannot Be Removed by Surgery

Phase 1 Completed

Gastrointestinal

Rectal Neoplasms

NCT02550743 2021-03-12

BrUOG 302:BYL719, Capecitabine and Radiation for Rectal Cancer: A Brown University Oncology Research Group Study

Phase 1 Terminated

7 enrolled 7 charts

Gastrointestinal

Neoplasm Metastasis, Rectal Neoplasms

NCT02641691 2021-02-18

NORMAL-R

Phase 2 Completed

20 enrolled 11 charts

Gastrointestinal

Rectal Neoplasms

NCT01302613 2020-08-20

Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or III Rectal Adenocarcinoma

Phase 1/2 Withdrawn

Gastrointestinal

Rectal Neoplasms

NCT01634685 2020-08-20

A Phase I Study of Bavituximab, Capecitabine, and Radiation for the Treatment of Rectal Adenocarcinoma

Phase 1 Completed

Gastrointestinal

Rectal Neoplasms

NCT00353457 2020-04-09

Capecitabine,Oxaliplatin & Erbitux Given Throughout Multi-Modal Therapy for Locally Advanced Rectal Adenocarcinoma

Phase 2 Terminated

Gastrointestinal

Rectal Neoplasms

NCT00321685 2019-03-27

Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Nonmetastatic Rectal Cancer

Phase 2 Completed

57 enrolled 10 charts

Gastrointestinal

Rectal Neoplasms

NCT00611858 2019-01-08

Cetuximab, 5-FU and Radiation as Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer

Phase 2 Terminated

13 enrolled 9 charts

Gastrointestinal

Rectal Neoplasms

NCT01197664 2018-07-02

Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer That Can Be Removed in Surgery

Phase 1 Terminated

Gastrointestinal

Rectal Neoplasms

NCT00114231 2018-03-29

Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients Who Are Undergoing Surgery for Stage I Rectal Cancer

Phase 2 Completed

90 enrolled 10 charts

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT01729923 2018-01-16

ADAPT

Phase 2 Terminated

27 enrolled 10 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT00682786 2017-10-06

Genotype-directed Neoadjuvant Chemoradiation for Rectal Carcinoma

Phase 2 Completed

135 enrolled 17 charts

Gastrointestinal

Carcinoma, Neoplasms, Rectal Neoplasms

NCT01749956 2017-02-07

5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer

Phase 2 Completed

39 enrolled 13 charts

Gastrointestinal

Rectal Neoplasms

NCT01376453 2016-09-12

Pre-operative 5-Fluorouracil (5-FU) and Sorafenib With External Radiation in Locally Advanced Rectal Cancer

Phase 1 Completed

Gastrointestinal

Adenocarcinoma, Rectal Neoplasms

NCT00250835 2015-09-01

Combination of Oxaliplatin, Capecitabine, and Celecoxib With Concurrent Radiation for Rectal Cancer

Phase 2 Terminated

38 enrolled 11 charts

Gastrointestinal

Neoplasms, Rectal Neoplasms

NCT01818973 2015-06-08

Preoporative Bevacizumab, Radiation Therapy, and XELOX Chemotherapy for Locally Advanced Nonmetastatic Rectal Cancer

Phase 2 Unknown

Gastrointestinal

Rectal Neoplasms

NCT01133340 2014-10-02

A Feasibility Study to Compare the Benefits of Endoscopic Tumor Clip Placement and 3T-MRI Simulation for Accurate Target Volume Definition for Rectal Cancer Patients Undergoing Pre-operative Chemoradiation

Phase NA Completed

Gastrointestinal

Rectal Neoplasms

NCT00215956 2013-12-23

A Phase I Study of Oral Topotecan as a Radiosensitizing Agent in Patients With Rectal Carcinoma

Phase 1 Completed

Gastrointestinal

Rectal Neoplasms

NCT00145769 2013-08-09

A Randomised Trial of Preoperative Radiotherapy for Stage T3 Adenocarcinoma of Rectum

Phase 3 Completed

Gastrointestinal

Rectal Neoplasms

NCT00003799 2013-01-10

Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Rectal Cancer

Phase 1 Completed

Gastrointestinal

Rectal Neoplasms

NCT01227239 2012-11-27

Preoperative S-1/OHP With Radiation Therapy for Low-lying Rectal Carcinoma in Neo-adjuvant Setting

Phase 1/2 Unknown

Gastrointestinal

Rectal Neoplasms

NCT00842686 2012-03-26

CRAB

Phase 2 Unknown

Gastrointestinal

Rectal Neoplasms

NCT00176787 2008-01-10

Radiation Therapy With Capecitabine in Rectal Cancer

Phase 2 Terminated

Gastrointestinal

Rectal Neoplasms

NCT00346099 2008-01-07

Study of Panitumumab Given First With Capecitabine and Oxaliplatin (CAPOX) and Then With Capecitabine and Radiation of the Pelvis for Treatment of Patients With Rectal Cancers That May or May Not Have Spread Beyond the Rectum

Phase 2 Withdrawn

Gastrointestinal

Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms