Clinical Trials

54 enrolled

Phase 2 Active not recruiting

Rectal Neoplasms

NCT05009069 2026-01-22

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

58 enrolled

Phase 2 Active not recruiting

Rectal Neoplasms

NCT00335816 2026-01-14

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

248 enrolled

Phase 2 Active not recruiting

Rectal Neoplasms, Colorectal Neoplasms

NCT03921684 2026-01-05

Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients

29 enrolled

Rectal Neoplasms

NCT07162714 2025-09-09

STAR

30 enrolled

Rectal Neoplasms

NCT06884670 2025-09-08

Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant Therapy for Locally Advanced Rectal Cancer Prior to Surgery: A Prospective, Multi-center, Randomized Controlled Study

130 enrolled

Rectal Neoplasms

NCT05024097 2025-08-27

PANTHER

43 enrolled

Rectal Neoplasms

NCT04525989 2025-08-20

PRORECT

Phase NA Recruiting

254 enrolled

Rectal Neoplasms

NCT06834126 2025-07-18

Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

Phase 1 Recruiting

36 enrolled

Rectal Neoplasms

NCT06780787 2025-06-26

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

26 enrolled

Rectal Neoplasms

NCT06501053 2025-06-06

CORRECT

Phase NA Recruiting

110 enrolled

Rectal Neoplasms

NCT06949098 2025-05-29

Tumor Local Excision +Postoperative Adjuvant Chemoradiotherapy for T1-2N0M0 Low/Ultra-Low Rectal Cancer

60 enrolled

Rectal Neoplasms

NCT06919510 2025-04-09

A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer

90 enrolled

Phase 2/3 Active not recruiting

Rectal Neoplasms

NCT02945566 2025-03-27

STAR-TREC

380 enrolled

Rectal Neoplasms

NCT04406857 2025-02-26

Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer

1 enrolled 7 charts

Rectal Neoplasms

NCT01643070 2025-02-25

Preoperative CRT With or Without Induction Chemotherapy for Rectal Cancer With Liver Metastases

Phase 2 Completed

38 enrolled 16 charts

Rectal Neoplasms

NCT04942626 2025-02-21

ACO/ARO/AIO-21

12 enrolled

Rectal Neoplasms

NCT06831981 2025-02-18

ARO 2024-13

Phase NA Recruiting

264 enrolled

Hyperthermia, Rectal Neoplasms

NCT03916510 2025-02-06

CEDAR

12 enrolled 13 charts

Adenoviridae Infections, Rectal Neoplasms

NCT06758830 2025-01-09

Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.

Phase 2/3 Recruiting

400 enrolled

Low Anterior Resection Syndrome, Fatigue, Postoperative Complications, Radiation Injuries, Rectal Neoplasms

NCT06765616 2025-01-09

Adebrelimab Injection (PD-L1) Combined With Short Course Radiotherapy and Chemotherapy for Neoadjuvant Therapy of Locally Advanced Rectal Cancer

31 enrolled

Rectal Neoplasms

NCT03565029 2024-12-27

NO-CUT

Phase 2 Completed

180 enrolled

Phase NA Not yet recruiting

Colonic Neoplasms, Rectal Neoplasms

NCT06729645 2024-12-20

ACO/ARO/AIO-22

80 enrolled

Rectal Neoplasms

NCT05916040 2024-12-04

TNTRect

Recruiting

35 enrolled

Rectal Neoplasms

NCT03300544 2024-05-23

Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer

3 enrolled 9 charts

Rectal Neoplasms

NCT06390982 2024-04-30

Organ Preservation With Tislelizumab and Total Neoadjuvant Therapy in Patients With Low Rectal Cancer: RELIEVE -01 Study

46 enrolled

Rectal Neoplasms

NCT06304545 2024-03-12

Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With Camrelizumab

48 enrolled

Rectal Neoplasms

NCT01769222 2024-01-24

Ipilimumab and Local Radiation for Selected Solid Tumors

DermatologicGastrointestinalLymphoidOther hematologic neoplasm

3 enrolled 5 charts

Burkitt Lymphoma, Colonic Neoplasms, Immunoblastic Lymphadenopathy, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Melanoma, Mycosis Fungoides, Rectal Neoplasms, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Peripheral, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Leukemia, Large Granular Lymphocytic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Intraocular Lymphoma

NCT02528175 2023-12-07

Magnetic Resonance-Guided High Intensity Focused Ultrasound for Recurrent Rectal Cancer

Phase NA Completed

6 enrolled

Rectal Neoplasms

NCT03729687 2023-11-30

LARCT-US

Phase 2 Unknown

280 enrolled

Rectal Neoplasms

NCT04787523 2023-11-07

Rectrospect

Completed

170 enrolled

Rectal Neoplasms

NCT00745134 2023-09-28

Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer

Phase 2 Terminated

22 enrolled 16 charts

Rectal Neoplasms

NCT01740648 2023-09-18

Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer

19 enrolled

Phase NA Not yet recruiting

Rectal Neoplasms

NCT06035133 2023-09-13

Treatment of Low Locally Advanced Rectal Cancer With Radiotherapy Removal TNT Plus Neoadjuvant Therapy

213 enrolled

Rectal Neoplasms

NCT00979680 2023-06-29

GRECCAR1

Phase 3 Completed

207 enrolled

Rectal Neoplasms

NCT04083365 2023-05-31

PANDORA

Phase 2 Unknown

100 enrolled

Rectal Neoplasms

NCT05868317 2023-05-22

Induction Chemotherapy Followed by Short Course Radiotherapy in Rectal Cancer

Phase 2 Unknown

70 enrolled

Rectal Neoplasms

NCT02288195 2023-05-12

CONVERT: Neoadjuvant Chemotherapy Alone Versus Preoperative Chemoradiation for Locally Advanced Rectal Cancer Patients

Phase 3 Unknown

663 enrolled

Rectal Neoplasms

NCT03299660 2023-03-16

Avelumab With Chemoradiation in Locally Advanced Rectal Cancer

Phase 2 Completed

37 enrolled

Rectal Neoplasms

NCT02910843 2023-01-10

RECAP

25 enrolled

Rectal Neoplasms

NCT03297710 2023-01-05

TAS-102 and Radiation Therapy in Treating Patients With Rectal Cancer That Is Locally Recurrent, Metastatic, or Cannot Be Removed by Surgery

7 enrolled

Rectal Neoplasms

NCT00280761 2022-08-11

Biomarkers in Patients With Rectal Cancer Undergoing Chemotherapy and Radiation Therapy

Completed

47 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT02935309 2022-05-31

Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma

20 enrolled