Clinical Trials Browser

NCT04362839 2026-01-28

Regorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer

Phase 1 Completed

39 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04853017 2025-09-05

AMPLIFY-201

Phase 1 Completed

25 enrolled 15 charts

GastrointestinalGynecologicThoracic

Bile Duct Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Gallbladder Neoplasms, Ovarian Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma, Neoplasm, Residual

NCT00873275 2025-06-22

Ursodiol, Combination Chemotherapy, and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer

Phase 1 Completed

11 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00059930 2025-03-26

Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer

Phase 1 Completed

38 enrolled

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT04942626 2025-02-21

ACO/ARO/AIO-21

Phase 1 Completed

12 enrolled

Gastrointestinal

Rectal Neoplasms

NCT05943041 2025-02-14

Live Biotherapeutic Product GB104 Phase 1 Study in Colorectal Cancer

Phase 1 Completed

9 enrolled

Gastrointestinal

Neoplasms, Rectal Neoplasms, Sigmoid Neoplasms, Colorectal Neoplasms

NCT03916510 2025-02-06

CEDAR

Phase 1 Completed

12 enrolled 13 charts

Gastrointestinal

Adenoviridae Infections, Rectal Neoplasms

NCT04164069 2024-12-27

Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab

Phase 1 Completed

9 enrolled

Gastrointestinal

Bile Duct Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT03251378 2024-09-25

A Multi-Center, Open-Label Study of Fruquintinib in Solid Tumors and Colorectal, and Breast Cancers

Phase 1 Completed

129 enrolled 32 charts

BreastGastrointestinal

Breast Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Triple Negative Breast Neoplasms

NCT05130060 2024-08-14

A Vaccine (PolyPEPI1018 Vaccine) and TAS-102 for the Treatment of Metastatic Colorectal Cancer

Phase 1 Completed

15 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04357587 2024-05-29

Safety and Feasibility of PD-1 Blockade in the Treatment of dMMR or MSI-H Rectal Cancer

Phase 1 Completed

6 enrolled

Gastrointestinal

Rectal Neoplasms

NCT01972373 2024-04-16

RAPIDO-TRACT

Phase 1 Completed

30 enrolled

Gastrointestinal

Rectal Neoplasms

NCT04638036 2024-04-16

TRACT-II

Phase 1 Completed

11 enrolled

Gastrointestinal

Rectal Neoplasms

NCT03317119 2024-04-08

Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery

Phase 1 Completed

26 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00019006 2024-03-04

Vaccine Therapy in Treating Patients With Colon, Pancreatic, or Lung Cancer

Phase 1 Completed

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Genetic Diseases, Inborn, Small Cell Lung Carcinoma

NCT00020267 2024-03-04

Vaccine Therapy in Treating Patients With Metastatic Cancer

Phase 1 Completed

BreastDermatologicGastrointestinalSarcomaThoracic

Uveal Melanoma, Bone Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Eye Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Rectal Neoplasms, Recurrence, Sarcoma, Osteosarcoma, Skin Neoplasms, Colorectal Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Breast Neoplasms, Male, Muscle Neoplasms, Genetic Diseases, Inborn, Histiocytoma, Malignant Fibrous

NCT03454451 2023-12-21

CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers

Phase 1 Completed

117 enrolled

BreastGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidSarcomaThoracic

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Sarcoma, Colorectal Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT01740648 2023-09-18

Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer

Phase 1 Completed

19 enrolled

Gastrointestinal

Rectal Neoplasms

NCT02232152 2023-08-07

CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery

Phase 1 Completed

19 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT00107250 2023-08-04

AZD2171 + Chemotherapy in Advanced NSCLC, Colorectal Cancer, or Other Cancer Suitable for Treatment With Capecitabine (Non-Small Lung Cancer Patients Closed to Enrollment as 8/9/07)

Phase 1 Completed

50 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00343408 2023-08-04

AZD2171 and Standard Combination Chemotherapy in Advanced Non-Small Cell Lung Cancer or Colorectal Cancer

Phase 1 Completed

31 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00535353 2023-08-04

AZD2281 and Irinotecan in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer

Phase 1 Completed

26 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02890758 2023-02-21

Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803

Phase 1 Completed

14 enrolled

GastrointestinalLymphoidMyeloidOther hematologic neoplasmPlasma cellSarcoma

Colonic Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Rectal Neoplasms, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03871959 2023-02-17

CATRIPCA

Phase 1 Completed

54 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT03297710 2023-01-05

TAS-102 and Radiation Therapy in Treating Patients With Rectal Cancer That Is Locally Recurrent, Metastatic, or Cannot Be Removed by Surgery

Phase 1 Completed

7 enrolled

Gastrointestinal

Rectal Neoplasms

NCT02602327 2022-08-01

Tas-102 and Radioembolization With 90Y Resin Microspheres for Chemo-refractory Colorectal Liver Metastases

Phase 1 Completed

21 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT05476341 2022-07-27

A Phase I Clinical Trial of Bevacizumab Injection

Phase 1 Completed

98 enrolled

CNSGastrointestinalGynecologicThoracic

Uterine Cervical Neoplasms, Glioblastoma, Lung Neoplasms, Ovarian Neoplasms, Rectal Neoplasms

NCT02935309 2022-05-31

Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma

Phase 1 Completed

20 enrolled

Gastrointestinal

Carcinoma, Rectal Neoplasms

NCT01113736 2022-05-12

AlloMem

Phase 1 Completed

10 enrolled

Gastrointestinal

Colonic Neoplasms, Constriction, Pathologic, Rectal Neoplasms, Surgical Wound Dehiscence

NCT02900664 2022-03-29

A Study of PDR001 in Combination With CJM112, EGF816, Ilaris® (Canakinumab) or Mekinist® (Trametinib)

Phase 1 Completed

283 enrolled

BreastGastrointestinalThoracic

Adenocarcinoma of Lung, Adenocarcinoma, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Intestinal Neoplasms, Lung Neoplasms, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Carcinoma, Ductal, Triple Negative Breast Neoplasms

NCT00101972 2022-02-22

RAV12 in Treating Patients With Metastatic or Recurrent Adenocarcinoma

Phase 1 Completed

53 enrolled

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Adenocarcinoma Of Esophagus, Adenocarcinoma of Lung, Carcinoma, Ovarian Epithelial, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Stomach Neoplasms, Vaginal Neoplasms, Endometrial Neoplasms

NCT03152370 2021-10-04

PRAER 1

Phase 1 Completed

29 enrolled

Gastrointestinal

Rectal Neoplasms

NCT02270606 2021-07-20

Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer

Phase 1 Completed

14 enrolled

Gastrointestinal

Rectal Neoplasms

NCT00695201 2021-07-01

Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Intravenous Oxaliplatin Plus Irinotecan in Patients With Unresectable Hepatic Metastases From Colorectal Cancer

Phase 1 Completed

52 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT01781403 2021-02-04

Preoperative CRT With Temozolomide Plus Capecitabine in Rectal Cancer

Phase 1 Completed

22 enrolled 5 charts

Gastrointestinal

Rectal Neoplasms

NCT01407107 2021-01-14

Dose Escalation Trial of Nitroglycerin, 5-flourouracil and Rad Therapy for Rectal Cancer

Phase 1 Completed

13 enrolled 8 charts

Gastrointestinal

Rectal Neoplasms

NCT02178644 2020-10-08

Pilot Trial of KD018 With Neo-Adjuvant Concurrent Chemo-Radiation Therapy in Patients With Locally Advanced Rectal Cancer

Phase 1 Completed

29 enrolled

Gastrointestinal

Rectal Neoplasms

NCT00959127 2020-09-16

A Study of ARRY-438162 (MEK162) in Patients With Advanced Cancer

Phase 1 Completed

93 enrolled

Gastrointestinal

Biliary Tract Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01634685 2020-08-20

A Phase I Study of Bavituximab, Capecitabine, and Radiation for the Treatment of Rectal Adenocarcinoma

Phase 1 Completed

15 enrolled

Gastrointestinal

Rectal Neoplasms

NCT00066404 2020-05-13

Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions

Phase 1 Completed

BreastDermatologicGastrointestinalGenitourinaryGynecologicOther solid neoplasmThoracic

Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymoma, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Pleural Effusion, Malignant, Endometrial Neoplasms, Breast Neoplasms, Male, Gestational Trophoblastic Disease, Small Cell Lung Carcinoma

NCT01643499 2020-05-08

Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies

Phase 1 Completed

79 enrolled

Gastrointestinal

Bile Duct Neoplasms, Colonic Neoplasms, Gallbladder Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT01254617 2020-03-13

ADCC

Phase 1 Completed

24 enrolled

GastrointestinalHead & Neck

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Colonic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms

NCT02574663 2019-10-02

TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors

Phase 1 Completed

66 enrolled

GastrointestinalSarcoma

Esophageal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Gastrointestinal Stromal Tumors

NCT00656123 2019-08-14

Study of Colon GVAX and Cyclophosphamide in Patients With Metastatic Colorectal Cancer

Phase 1 Completed

9 enrolled

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT01923337 2019-01-04

Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer

Phase 1 Completed

17 enrolled

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01282502 2018-12-12

Midostaurin (PKC412) for Locally Advanced Rectal Cancer

Phase 1 Completed

19 enrolled

Gastrointestinal

Rectal Neoplasms

NCT01560377 2018-12-11

PILLAR II

Phase 1 Completed

147 enrolled 14 charts

Gastrointestinal

Colonic Neoplasms, Crohn Disease, Diverticulitis, Polyps, Prolapse, Rectal Neoplasms

NCT00685568 2018-11-07

Celecoxib in Preventing Colorectal Cancer in Young Patients With a Genetic Predisposition for Familial Adenomatous Polyposis

Phase 1 Completed

22 enrolled

GastrointestinalOther neoplasm

Colonic Neoplasms, Adenomatous Polyposis Coli, Precancerous Conditions, Rectal Neoplasms, Colorectal Neoplasms

NCT00003867 2018-09-10

Irinotecan and Capecitabine in Treating Patients With Solid Tumors

Phase 1 Completed

30 enrolled

BreastGastrointestinal

Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT00458809 2018-08-09

Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer

Phase 1 Completed

16 enrolled

Gastrointestinal

Appendiceal Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms