Clinical Trials Browser

Phase 2 × INDUSTRY × Rectal Neoplasms × Clear all

NCT06607458 2026-06-01

DEL-LIVER

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT05723562 2026-05-26

AZUR-1

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT05513742 2026-05-06

COMPANION-003

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05009069 2026-04-21

A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT05217446 2026-04-07

SEAMARK

Phase 2 Active not recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT06640049 2025-11-17

China AZUR-1

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT02399813 2023-03-20

A Phase 2 Study of Axalimogene Filolisbac (ADXS11-001) in Participants With Carcinoma of the Anorectal Canal

Phase 2 Completed

36 enrolled 11 charts

Gastrointestinal

Anus Neoplasms, Rectal Neoplasms

NCT00819780 2022-12-06

PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors

Phase 2 Completed

285 enrolled 31 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT01915472 2021-08-19

A Phase II Study of IMMU 130 in Patients With Metastatic Colorectal Cancer

Phase 2 Withdrawn

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT00361842 2021-07-02

Multicenter Study Of CPX-1 (Irinotecan HCl: Floxuridine) Liposome Injection In Patients With Advanced Colorectal Cancer

Phase 2 Completed

65 enrolled 10 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01609231 2020-05-04

MK-0646-025

Phase 2 Terminated

11 enrolled 8 charts

Gastrointestinal

Rectal Neoplasms

NCT02425683 2020-02-10

Study of Colorectal Cancer Patients (Stage IIIC) With Either Regorafenib or Standard of Care (No Treatment) After Adjuvant FOLFOX

Phase 2 Terminated

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01111604 2019-08-06

A Study of Ramucirumab or Icrucumab in Colorectal Cancer

Phase 2 Completed

158 enrolled 17 charts

Gastrointestinal

Adenocarcinoma, Colonic Neoplasms, Rectal Neoplasms

NCT02305758 2018-11-20

Study Comparing Veliparib Plus FOLFIRI Versus Placebo Plus FOLFIRI With or Without Bevacizumab in Previously Untreated Metastatic Colorectal Cancer

Phase 2 Completed

130 enrolled 12 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00094809 2018-10-17

Chemotherapy Administered Every 2 Weeks With or Without Pegfilgrastim in Subjects With Advanced or Metastatic Colon Cancer

Phase 2 Completed

252 enrolled 19 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00418938 2018-10-17

SPIRITT - Second-Line Panitumumab Irinotecan Treatment Trial

Phase 2 Completed

266 enrolled 17 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00845039 2018-07-02

FC-4

Phase 2 Terminated

4 enrolled 9 charts

Gastrointestinal

Colonic Neoplasms, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00865189 2017-08-04

INOVA

Phase 2 Completed

91 enrolled 16 charts

Gastrointestinal

Rectal Neoplasms

NCT01507103 2017-01-13

SPRINT

Phase 2 Completed

124 enrolled 9 charts

Gastrointestinal

Carcinoma, Neoplasms, Neoplasms by Site, Rectal Neoplasms

NCT02694718 2017-01-11

A Study of Capecitabine Plus Oxaliplatin in Combination With Pre-operative Pelvic Radiotherapy in Rectal Cancer

Phase 2 Completed

60 enrolled 10 charts

Gastrointestinal

Rectal Neoplasms

NCT00527111 2016-11-03

Pre-op Rectal ChemoRad +/- Cetuximab

Phase 2 Completed

139 enrolled 12 charts

Gastrointestinal

Rectal Neoplasms

NCT00813605 2016-10-27

QUILT-2.018: Safety & Efficacy of FOLFIRI With AMG 479 or AMG 655 vs FOLFIRI Alone in KRAS-mutant Metastatic Colorectal Carcinoma

Phase 2 Completed

Gastrointestinal

Adenocarcinoma, Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00454116 2016-10-07

A Phase II, Double Blind Study of 2 Doses of ZACTIMA™(ZD6474) in Combination With FOLFIRI vs FOLFIRI Alone for the Treatment of Colorectal Cancer in Patients

Phase 2 Completed

106 enrolled 8 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00851084 2016-06-07

AFFIRM

Phase 2 Completed

268 enrolled 16 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00022698 2016-04-15

Capecitabine and Irinotecan in Treating Patients With Locally Advanced, Recurrent, or Metastatic Colorectal Cancer

Phase 2 Completed

67 enrolled 15 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00332163 2016-02-23

STEPP

Phase 2 Completed

95 enrolled 23 charts

Gastrointestinal

Colonic Neoplasms, Exanthema, Rectal Neoplasms, Colorectal Neoplasms

NCT00411450 2016-02-15

PRECEPT

Phase 2 Completed

116 enrolled 20 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00752570 2015-09-02

A Phase 2, Randomized, Double Blind, Placebo Controlled Study of AMG 386 in Combination With FOLFIRI in Subjects With Previously Treated Metastatic Colorectal Carcinoma

Phase 2 Completed

Gastrointestinal

Carcinoma, Colonic Neoplasms, Gastrointestinal Neoplasms, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00096083 2013-10-23

Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer

Phase 2 Completed

DermatologicEndocrineGastrointestinal

Adenocarcinoma Of Esophagus, Uveal Melanoma, Appendiceal Neoplasms, Bile Duct Neoplasms, Colonic Neoplasms, Vipoma, Esophageal Neoplasms, Gallbladder Neoplasms, Glucagonoma, Carcinoma, Hepatocellular, Insulinoma, Melanoma, Neoplasms, Pancreatic Neoplasms, Pheochromocytoma, Rectal Neoplasms, Somatostatinoma, Stomach Neoplasms, Carcinoma, Islet Cell, Carcinoma, Medullary

NCT01075399 2013-08-30

HX4-200

Phase 2 Completed

50 enrolled 7 charts

GastrointestinalGynecologicHead & NeckThoracic

Hypoxia, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Rectal Neoplasms

NCT00707889 2013-05-15

Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT00111774 2013-05-14

Evaluating ABX-EGF in Patients With Metastatic ColorectalCarcinoma

Phase 2 Completed

Gastrointestinal

Carcinoma, Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00988936 2012-08-22

K5-101

Phase 2 Completed

BreastGastrointestinalThoracic

Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms, Rectal Neoplasms

NCT00080834 2012-05-16

DJ-927 as Second-Line Therapy in Treating Patients With Progressive Locally Advanced or Metastatic Colorectal Adenocarcinoma

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00137878 2012-02-23

TNFerade™ Plus Chemo/Radiation/Surgery for Rectal Cancer

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT00113776 2011-01-21

Evaluating ABX-EGF Extended Therapy in Subjects With MetastaticColorectal Cancer

Phase 2 Completed

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00421824 2011-01-04

Study of Neoadjuvant Chemotherapeutic Treatment (XELOX) Followed by Chemoradiotherapy (XELOX/RT) and Surgery Versus Chemoradiotherapy Followed by Surgery and Chemotherapy in Patients With High Risk Rectal Cancer

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT00174616 2009-12-07

CORE: Capecitabine, Oxaliplatin, Radiotherapy and Excision

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT00263029 2009-09-18

PROCTFUL

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT00063427 2009-08-21

Study Evaluating MAC-321 in Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00072748 2009-08-21

Study Evaluating EKB-569 in Advanced Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT00330915 2009-07-21

A Study of Pemetrexed and Folic Acid Given Before Surgery (Neoadjuvant Treatment) to Patients With Rectal Cancer.

Phase 2 Completed

37 enrolled 18 charts

Gastrointestinal

Rectal Neoplasms

NCT00235898 2008-08-25

Clinical Trial in Patients With Metastatic Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT00590278 2008-01-25

TOMUDEX

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT00081627 2007-11-27

Clinical Trial in Patients With Metastatic Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms