Clinical Trials Browser

Phase 2 × OTHER × Rectal Neoplasms × Clear all

NCT07405476 2026-04-17

Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment

Phase 2 Recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT06569368 2026-04-16

Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07527520 2026-04-14

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT02688712 2026-04-13

ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT06417476 2026-04-13

Short-course Radiotherapy or Long-course Chemoradiation Followed by mFOLFOXIRI Consolidation Chemotherapy for Organ Preservation in Low Rectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT06162650 2026-04-08

Total Neoadjuvant Therapy in Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07516210 2026-04-07

ART-Hypo

Phase 2 Not yet recruiting

GastrointestinalGenitourinaryGynecologic

Uterine Cervical Neoplasms, Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT07292298 2026-04-06

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07509424 2026-04-03

Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecitabine in Locally Advanced HER2-expressing Rectal Cance

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT05515796 2026-04-01

Multi-omics Sequencing in Neoadjuvant Immunotherapy of Gastrointestinal Tumors

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms, Stomach Neoplasms

NCT02437656 2026-03-31

METCAP

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT04963283 2026-03-31

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04503694 2026-03-27

REGINA

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT07281768 2026-03-20

Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal Cancer

Phase 2 Not yet recruiting

Gastrointestinal

Adenocarcinoma, Carcinoma, Rectal Neoplasms, Colorectal Neoplasms

NCT05806931 2026-03-18

SCOTI

Phase 2 Recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT07011576 2026-03-18

FRUITFUL

Phase 2 Recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07458529 2026-03-10

NCRIT-PM9

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07460596 2026-03-10

Concentrated Complex Plant Dietary Elements for Chemotherapy-Induced Diarrhea

Phase 2 Completed

Gastrointestinal

Esophageal Neoplasms, Rectal Neoplasms

NCT06647680 2026-03-06

Neoadjuvant Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer（CONTROL-01）

Phase 2 Recruiting

Gastrointestinal

Pathologic Complete Response, Rectal Neoplasms

NCT05731726 2026-03-05

Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05672524 2026-03-04

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Adenocarcinoma, Rectal Neoplasms

NCT06608537 2026-03-04

A Clinical Study Based on FAPI-PET/CT Technology to Predict Pathological Complete Response After Neoadjuvant Chemoradiotherapy for MSS Rectal Cancer

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT07176182 2026-02-27

Clinical Trial of Neoadjuvant mFOLFOX Plus Alvenor for LARC Patients With High YWHAB Expression

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT07223567 2026-02-25

A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing pMMR/MSS Localized Rectal Cancer

Phase 2 Withdrawn

Gastrointestinal

Rectal Neoplasms

NCT07433673 2026-02-25

GAP Cemi

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07337876 2026-02-17

MARS

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07407465 2026-02-17

CHIMERA

Phase 2 Recruiting

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT05673772 2026-02-12

SOLAR

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT07407647 2026-02-12

Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer

Phase 2 Recruiting

GastrointestinalGynecologic

Anus Neoplasms, Uterine Cervical Neoplasms, Rectal Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT07397442 2026-02-11

Short-Course Radiotherapy Combined With Chemotherapy and Immunotherapy in Mid-Low Locally Advanced Rectal Cancer

Phase 2 Not yet recruiting

Gastrointestinal

Pathologic Complete Response, Rectal Neoplasms

NCT07402486 2026-02-11

A Phase II Prospective Study of Maastro Applicator Brachytherapy for Rectal Cancer

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT04109924 2026-02-10

TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study

Phase 2 Completed

42 enrolled 12 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07227636 2026-02-06

A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT07394192 2026-02-06

PKUCH- R11

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT00556413 2026-02-05

Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07381400 2026-02-03

Neoadjuvant mFOLFOX6 Chemotherapy Combined With Anti-PD-1 Therapy in MSS/pMMR Locally Advanced Rectal Cancer (FIRM02 Study)

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT04643366 2026-01-27

Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04165772 2026-01-23

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04505553 2026-01-21

Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer

Phase 2 Completed

78 enrolled 14 charts

EndocrineGastrointestinalNET

Gastro-enteropancreatic neuroendocrine tumor, Anus Neoplasms, Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Carcinoma, Hepatocellular, Adenoma, Islet Cell, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT00826540 2026-01-20

Sorafenib and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

Phase 2 Completed

83 enrolled 10 charts

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT07209215 2026-01-20

ULTIMATE

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT07347951 2026-01-16

A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT00335816 2026-01-14

Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT07068763 2026-01-06

mRCAT-E

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT03921684 2026-01-05

Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms

NCT07302126 2025-12-24

Preventive Efficacy of Bergmann Enema for Acute Radiation-induced Rectal Injury in Rectal Cancer Patients Undergoing Short-course Radiotherapy

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT07297030 2025-12-22

SIB-RT Combined With CAPOX and PD-1 for High-Risk Rectal Cancer

Phase 2 Not yet recruiting

Gastrointestinal

Rectal Neoplasms

NCT04417699 2025-12-10

SHORT

Phase 2 Completed

13 enrolled 12 charts

Gastrointestinal

Rectal Neoplasms

NCT05358704 2025-12-04

Preoperative ChemoRadiation And FOLFOXIRI for Rectal Cancer (CRAFTER) for Rectal Cancer

Phase 2 Suspended

Gastrointestinal

Rectal Neoplasms

NCT07160647 2025-12-02

Neo-IT

Phase 2 Active not recruiting

Gastrointestinal

Rectal Neoplasms