Clinical Trials Browser

Phase 2 × Recruiting × Rectal Neoplasms × Clear all

NCT06569368 2026-04-16

Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06162650 2026-04-08

Total Neoadjuvant Therapy in Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07292298 2026-04-06

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05806931 2026-03-18

SCOTI

Phase 2 Recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms

NCT07011576 2026-03-18

FRUITFUL

Phase 2 Recruiting

Gastrointestinal

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT06607458 2026-03-13

DEL-LIVER

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT07458529 2026-03-10

NCRIT-PM9

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06647680 2026-03-06

Neoadjuvant Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer（CONTROL-01）

Phase 2 Recruiting

Gastrointestinal

Pathologic Complete Response, Rectal Neoplasms

NCT05731726 2026-03-05

Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05672524 2026-03-04

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Adenocarcinoma, Rectal Neoplasms

NCT07433673 2026-02-25

GAP Cemi

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07337876 2026-02-17

MARS

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07407465 2026-02-17

CHIMERA

Phase 2 Recruiting

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT07407647 2026-02-12

Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer

Phase 2 Recruiting

GastrointestinalGynecologic

Anus Neoplasms, Uterine Cervical Neoplasms, Rectal Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT07227636 2026-02-06

A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms, Colorectal Neoplasms

NCT04643366 2026-01-27

Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04165772 2026-01-23

Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07347951 2026-01-16

A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07068763 2026-01-06

mRCAT-E

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07284992 2025-12-16

SCRT VS LCRT Followed by PD-L1 Inhibitor Plus CAPEOX as TNT in Patients With LARC

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07198165 2025-09-30

SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06577194 2025-09-19

A Single-Center, Single-Arm Study of Neoadjuvant Short-Course Radiotherapy With IL-2 Followed by Sequential Immunotherapy With CAPOX Combined With PD-1 Antibody and IL-2 for Locally Advanced Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06884670 2025-09-08

Assessment of Efficacy and Safety of PD-1 Monoclonal Antibody Combined With IL-2 and CapeOX in Neoadjuvant Therapy for Locally Advanced Rectal Cancer Prior to Surgery: A Prospective, Multi-center, Randomized Controlled Study

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06770270 2025-09-04

PUCRT

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05722288 2025-08-29

Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers

Phase 2 Recruiting

GastrointestinalGenitourinary

Prostatic Neoplasms, Rectal Neoplasms

NCT05576480 2025-08-28

SPARC

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05024097 2025-08-27

PANTHER

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05254327 2025-08-07

Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05732389 2025-08-07

RESET-R

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07108127 2025-08-06

NePHera

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT07095439 2025-07-31

Efficacy and Toxicity of Total Neoadjuvant Sandwich Treatment Via Short Course Radiotherapy in the Treatment of Stage II and III Rectal Cancer Patients

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06940388 2025-07-24

TOTAL

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06780787 2025-06-26

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06949098 2025-05-29

Tumor Local Excision +Postoperative Adjuvant Chemoradiotherapy for T1-2N0M0 Low/Ultra-Low Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06908031 2025-05-14

CRIT

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05965531 2025-04-29

TASLARC

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06911684 2025-04-23

Radiotherapy Plus Iparomlimab and Tuvonralimab (QL1706), Regorafenib, and CAPOX as Neoadjuvant Therapy for pMMR/MSS LARC.

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06923345 2025-04-18

Modified Long-Course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for MSS/pMMR High-risk Mid/Low LARC (MODIFI-RC-I)

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06718543 2025-04-10

TRIUNITE-03

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06210971 2025-03-13

Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06812728 2025-02-19

Neoadjuvant FOLFIRINOX and Preoperative Chemoradiotherapy for Locally Advanced Rectal Cancer Patients

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06793137 2025-01-29

Intestinal Microbiome Modulation With Antibiotics in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06765616 2025-01-09

Adebrelimab Injection (PD-L1) Combined With Short Course Radiotherapy and Chemotherapy for Neoadjuvant Therapy of Locally Advanced Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06204094 2025-01-07

CASINOs

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06542588 2024-12-18

Short-Course Radiotherapy Followed by Neoadjuvant Chemotherapy, HLX07and Serplulimab in LARC

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT05628038 2024-10-01

TORCH-R

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT06455124 2024-06-13

Short-course Radiotherapy Combined With CapeOx and PD-1 Inhibitor After Local Excision for High-risk Early Rectal Cancer (TORCH-LE)

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT03714490 2024-05-29

SUNRISE

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms

NCT04755920 2024-05-09

SGM-CBM

Phase 2 Recruiting

CNSGastrointestinal

Brain Diseases, Brain Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05228431 2024-04-22

Modified Sandwich Therapeutic Regimen for Locally Advanced Rectal Cancer

Phase 2 Recruiting

Gastrointestinal

Rectal Neoplasms