Clinical Trials Browser

Colonic Neoplasms, Rectal Neoplasms

NCT07113275 2026-05-13

A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in Locally Advanced Rectal Cancer

Phase 3 Recruiting

444 enrolled

Gastrointestinal

Rectal Neoplasms

NCT06123156 2026-05-12

RECTIL

Phase 3 Recruiting

188 enrolled

Gastrointestinal

Rectal Neoplasms

NCT06205485 2026-05-12

NEO-RT

Phase 3 Recruiting

250 enrolled

Gastrointestinal

Rectal Neoplasms

NCT06936774 2026-05-06

iRECOVER

Phase 3 Recruiting

140 enrolled

Gastrointestinal

Low Anterior Resection Syndrome, Rectal Neoplasms

NCT07528209 2026-04-30

Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer

Phase 3 Recruiting

556 enrolled

Gastrointestinal

Rectal Neoplasms

NCT06850090 2026-04-28

Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial

Phase 3 Recruiting

210 enrolled

Gastrointestinal

Rectal Neoplasms

NCT04215731 2026-03-03

FOBEAR

Phase 3 Recruiting

582 enrolled

Gastrointestinal

Rectal Neoplasms

NCT04495088 2026-02-02

Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer

Phase 3 Recruiting

550 enrolled

Gastrointestinal

Rectal Neoplasms

NCT07372300 2026-01-28

mEHT

Phase 3 Recruiting

126 enrolled

Gastrointestinal

Hyperthermia, Rectal Neoplasms

NCT03875781 2026-01-15

NORAD01

Phase 3 Recruiting

540 enrolled

Gastrointestinal

Rectal Neoplasms

NCT04095299 2026-01-08

WW3

Phase 3 Recruiting

162 enrolled

Gastrointestinal

Rectal Neoplasms

NCT07070622 2025-07-17

OPLAR

Phase 3 Recruiting

186 enrolled

Gastrointestinal

Rectal Neoplasms

NCT06507371 2025-06-26

mRCAT-III

Phase 3 Recruiting

170 enrolled

Gastrointestinal

Rectal Neoplasms

NCT05482516 2025-05-22

MRD-GI

Phase 3 Recruiting

20 enrolled

Gastrointestinal

Colonic Neoplasms, Carcinoma, Hepatocellular, Rectal Neoplasms

NCT06968221 2025-05-15

Bovine Reinforcement in Stomach, Colorectal and Lung Operation

Phase 3 Recruiting

172 enrolled

GastrointestinalThoracic

Lung Neoplasms, Rectal Neoplasms

NCT05646511 2025-04-03

ENSEMBLE

Phase 3 Recruiting

608 enrolled

Gastrointestinal

Digestive System Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05939687 2024-08-07

ProMeLAR

Phase 3 Recruiting

142 enrolled

Gastrointestinal

Incisional Hernia, Neoplasms, Rectal Neoplasms

NCT06229041 2024-01-29

Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi)

Phase 3 Recruiting

472 enrolled

Gastrointestinal

Rectal Neoplasms

NCT06017583 2023-10-11

Neoadjuvant Chemotherapy With PD-1 Inhibitors Combined With SIB-IMRT in the Treatment of Locally Advanced Rectal Cancer

Phase 3 Recruiting

48 enrolled

Gastrointestinal

Rectal Neoplasms

NCT05984485 2023-08-09

TaLaR-02

Phase 3 Recruiting

766 enrolled

Gastrointestinal

Rectal Neoplasms

NCT05752136 2023-05-08

Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma

Phase 3 Recruiting

108 enrolled

Gastrointestinal

Rectal Neoplasms

NCT04087421 2023-05-03

Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome

Phase 3 Recruiting

114 enrolled

Gastrointestinal

Low Anterior Resection Syndrome, Rectal Neoplasms

NCT04389086 2022-09-06

PelvEx II

Phase 3 Recruiting

364 enrolled

Gastrointestinal

Margins of Excision, Rectal Neoplasms

NCT05201430 2022-03-04

RCNAC

Phase 3 Recruiting

300 enrolled

Gastrointestinal

Rectal Neoplasms

NCT04288999 2020-06-04

JCOG1801

Phase 3 Recruiting

110 enrolled

Gastrointestinal

Rectal Neoplasms

NCT03671252 2019-01-23

Prospectively Randomized Control Clinical Trial of FOLFOXIRI Preoperative Chemotherapy Alone on Rectal Cancer in Local Advance Comparing to Oral Capecitabine Combined With Long-term Radiation

Phase 3 Recruiting

776 enrolled

Gastrointestinal

Rectal Neoplasms

Clinical Trials

KANDLELIT-012

A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in Locally Advanced Rectal Cancer

RECTIL

NEO-RT

iRECOVER

Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer

Neoadjuvant Radiotherapy for Rectal Adenocarcinoma With Capecitabine Versus TAS-102 (Neo-REACT): A Multi-center, Randomized, Phase III Trial

FOBEAR

Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer

mEHT

NORAD01

WW3

OPLAR

mRCAT-III

MRD-GI

Bovine Reinforcement in Stomach, Colorectal and Lung Operation

ENSEMBLE

ProMeLAR

Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi)

Neoadjuvant Chemotherapy With PD-1 Inhibitors Combined With SIB-IMRT in the Treatment of Locally Advanced Rectal Cancer

TaLaR-02

Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma

Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome

PelvEx II

RCNAC

JCOG1801

Prospectively Randomized Control Clinical Trial of FOLFOXIRI Preoperative Chemotherapy Alone on Rectal Cancer in Local Advance Comparing to Oral Capecitabine Combined With Long-term Radiation