Clinical Trials

60 enrolled

Rectal Neoplasms

NCT06274190 2026-04-15

Treatable

158 enrolled

Low Anterior Resection Syndrome, Rectal Neoplasms

NCT07458347 2026-04-15

A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

GastrointestinalGynecologicThoracic

145 enrolled

Biliary Tract Neoplasms, Colonic Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma

NCT06205485 2026-04-14

NEO-RT

250 enrolled

Rectal Neoplasms

NCT07528209 2026-04-14

Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer

556 enrolled

Rectal Neoplasms

NCT06837831 2026-04-13

Mepilex Lite Dressings for the Treatment of Acute Radiation Dermatitis of Anal Canal Skin

274 enrolled

Rectal Neoplasms

NCT06997497 2026-04-13

KANDLELIT-012

477 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT06746012 2026-04-09

Designing a Dyad-Based mHealth Intervention to Improve Adherence to Lifestyle Recommendations in Colorectal Cancer Survivors and Their Family Caregivers

70 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT06162650 2026-04-08

Total Neoadjuvant Therapy in Rectal Cancer

42 enrolled

Rectal Neoplasms

NCT07283939 2026-04-07

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

420 enrolled

Appendiceal Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT07292298 2026-04-06

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

44 enrolled

Rectal Neoplasms

NCT07512232 2026-04-06

TOWER-2

1,598 enrolled

Rectal Neoplasms

NCT05080673 2026-04-02

FORTE

9,500 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT07505472 2026-04-01

STARS-RC10

Phase 2/3 Recruiting

212 enrolled

Rectal Neoplasms

NCT04703101 2026-03-30

Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer

25 enrolled

Rectal Neoplasms

NCT07494201 2026-03-27

MIMICC

2,500 enrolled

Colonic Neoplasms, Rectal Neoplasms, Recurrence, Colorectal Neoplasms, Anastomotic Leak

NCT07369531 2026-03-25

FIAS

520 enrolled

Neoplasms, Rectal Neoplasms

NCT07213609 2026-03-23

A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

GastrointestinalGynecologic

47 enrolled

Turcot syndrome, Colonic Neoplasms, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT06628674 2026-03-20

Developing and Testing the Effect of Online Interactive Videos in Improving Low Anterior Resection Syndrome.

110 enrolled

Rectal Neoplasms

NCT04674267 2026-03-18

REACH

257 enrolled

Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT05806931 2026-03-18

SCOTI

50 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT06637462 2026-03-18

A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer

30 enrolled

Rectal Neoplasms

NCT07011576 2026-03-18

FRUITFUL

60 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT07351071 2026-03-17

SECURE

137 enrolled

Colonic Diseases, Digestive System Diseases, Gastrointestinal Diseases, Intestinal Diseases, Postoperative Complications, Rectal Diseases, Rectal Neoplasms, Anastomotic Leak

NCT04808323 2026-03-16

MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer

22 enrolled

Rectal Neoplasms

NCT07474103 2026-03-16

SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARC

49 enrolled

Rectal Neoplasms

NCT06607458 2026-03-13

DEL-LIVER

90 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT07209787 2026-03-13

SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter RCT on Anastomotic Leak

Phase 4 Recruiting

966 enrolled

Rectal Neoplasms

NCT06802172 2026-03-10

Effect of Meal Timing During Cancer Treatment in Patients in Alaska: A Randomized Clinical Trial

100 enrolled

BreastGastrointestinal

Intermittent Fasting, Breast Neoplasms, Rectal Neoplasms

NCT07458529 2026-03-10

NCRIT-PM9

50 enrolled

Rectal Neoplasms

NCT06647680 2026-03-06

Neoadjuvant Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer（CONTROL-01）

35 enrolled

Pathologic Complete Response, Rectal Neoplasms

NCT05731726 2026-03-05

Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer

50 enrolled

Rectal Neoplasms

NCT06952101 2026-03-05

INTERPRETE

200 enrolled

Rectal Neoplasms

NCT05672524 2026-03-04

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

37 enrolled

Adenocarcinoma, Rectal Neoplasms

NCT04215731 2026-03-03

FOBEAR

582 enrolled

Rectal Neoplasms

NCT06447662 2026-02-25

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

330 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal

NCT06769061 2026-02-25

AcuCIN

75 enrolled

Rectal Neoplasms

NCT07433673 2026-02-25

GAP Cemi

20 enrolled

Rectal Neoplasms

NCT07427901 2026-02-23

Quality Of Life In Colorectal Cancer Survivors

368 enrolled

Colonic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT04907643 2026-02-20

Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

EndocrineGastrointestinalNET

360 enrolled

Cancer Pain, Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Biliary Tract Neoplasms, Carcinoid Tumor, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Gastrointestinal Neoplasms, Liver Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Rectal Neoplasms, Recurrence, Stomach Neoplasms, Neuroendocrine Tumors, Visceral Pain

NCT06051695 2026-02-20

EVEREST-2

GastrointestinalGynecologicOther solid neoplasmThoracic

474 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Recurrence, Colorectal Neoplasms

NCT07419490 2026-02-19

UOT WPXRT

26 enrolled

Colonic Neoplasms, Rectal Neoplasms

NCT03051464 2026-02-17

Morpheus

Phase 2/3 Recruiting

131 enrolled

Rectal Neoplasms

NCT07337876 2026-02-17

MARS

100 enrolled

Rectal Neoplasms

NCT07407465 2026-02-17

CHIMERA

42 enrolled

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT04339374 2026-02-12

Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer

90 enrolled

Rectal Neoplasms, Colorectal Neoplasms

NCT07407647 2026-02-12

Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer

GastrointestinalGynecologic

25 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Rectal Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT03516708 2026-02-11

Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

49 enrolled

Rectal Neoplasms

NCT06128551 2026-02-10

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

GastrointestinalGynecologicThoracic

534 enrolled

Appendiceal Neoplasms, Bronchial Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Stomach Neoplasms, Thoracic Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Carcinoma, Pancreatic Ductal

NCT06337552 2026-02-09

High-Fermented Food Intervention Among Locally Advanced Rectal Cancer Patients (The FEED Trial)