Clinical Trials

Hydrophthalmos, Retinoblastoma

NCT06679634 2026-04-14

Retinoblastoma Phase II Expanded Access Clinical Trial

Phase 2 Recruiting

30 enrolled

CNSDermatologicEndocrineHead & NeckOther solid neoplasmSarcomaThoracic

Retinoblastoma

NCT05199584 2026-03-05

A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations

Phase 2 Completed

20 enrolled

Uveal Melanoma, Glioma, Adenoma, Islet Cell, Laryngeal Diseases, Medulloblastoma, Melanoma, Mesothelioma, Neuroblastoma, Pituitary Diseases, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma

NCT05504291 2026-02-17

A Study to Give Treatment Inside the Eye to Treat Retinoblastoma

Phase 2 Recruiting

26 enrolled

Retinoblastoma

NCT02870907 2026-01-07

RB SFCE 09

195 enrolled

Retinoblastoma

NCT05650749 2025-12-29

GPC2

Phase 1 Recruiting

45 enrolled

CNSOther solid neoplasm

Neuroblastoma, Retinoblastoma

NCT04681417 2025-11-28

RETINO 2018

Phase 2/3 Recruiting

225 enrolled

Retinoblastoma

NCT02866136 2025-11-24

RETINO2011

133 enrolled

Phase 1 Active not recruiting

Retinoblastoma, Retinal Neoplasms

NCT03618381 2025-11-20

EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

44 enrolled

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Carcinoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT04483778 2025-11-20

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Phase 1 Active not recruiting

68 enrolled

CNSDermatologicGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT04344652 2025-09-26

Photoscreening for Retinoblastoma

Phase NA Withdrawn

Phase NA Active not recruiting

Retinoblastoma

NCT03026998 2025-09-15

DepiSCARRH

88 enrolled

Retinoblastoma

NCT00186888 2025-09-04

Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma

Phase 3 Completed

107 enrolled 34 charts

Other solid neoplasmSarcoma

Eye Neoplasms, Retinoblastoma, Retinal Neoplasms

NCT04040205 2025-07-20

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

Phase 2 Recruiting

44 enrolled

Chondrosarcoma, Retinoblastoma, Sarcoma, Osteosarcoma

NCT06424301 2025-06-26

Targeting NUDT21 siRNA Drugs for Patients With Refractory Retinoblastoma

Phase EARLY_PHASE1 Recruiting

2 enrolled

Phase EARLY_PHASE1 Recruiting

Retinoblastoma

NCT06972602 2025-05-15

High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous Seed

10 enrolled

Recurrence, Retinoblastoma

NCT04342572 2025-05-11

IAC

5 enrolled

Retinoblastoma

NCT04903678 2025-02-25

Intrathecal Chemotherapy for Central Nervous System Metastasis in Retinoblastoma

Phase NA Recruiting

18 enrolled

Retinoblastoma

NCT04428879 2024-12-13

STEP-RB

26 enrolled

Eye Diseases, Eye Neoplasms, Neoplasms, Retinal Diseases, Retinoblastoma, Eye Diseases, Hereditary, Retinal Neoplasms

NCT03284268 2024-08-27

RTB

13 enrolled

Recurrence, Retinoblastoma

NCT00110110 2024-04-17

Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma

71 enrolled

Retinoblastoma

NCT01783535 2024-04-16

Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

174 enrolled

Phase 3 Active not recruiting

Retinoblastoma

NCT01906814 2024-04-09

Adjuvant Chemotherapy for High-risk Retinoblastoma After Enucleation

179 enrolled

CNSDermatologicGynecologicOther solid neoplasmSarcomaThoracic

Retinoblastoma

NCT00445965 2024-04-04

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Phase 2 Completed

78 enrolled 11 charts

Familial ependymoma, Uveal Melanoma, Astrocytoma, Brain Neoplasms, Chondrosarcoma, Ependymoma, Glioblastoma, Glioma, Lung Neoplasms, Medulloblastoma, Melanoma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Neuroectodermal Tumors, Primitive, Neoplasms, Neuroepithelial, Glioma, Subependymal, Gliosarcoma, Rhabdoid Tumor, Optic Nerve Glioma, Small Cell Lung Carcinoma, Desmoplastic Small Round Cell Tumor

NCT01505569 2024-02-26

Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

44 enrolled

Brain Neoplasms, Carcinoma, Renal Cell, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Rhabdoid Tumor

NCT01661400 2024-01-31

ASCR

CNSGenitourinaryOther solid neoplasmSarcoma

14 enrolled

Glioma, Medulloblastoma, Wilms Tumor, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Neuroectodermal Tumors, Primitive

NCT04564521 2023-11-22

Nitroglycerin for Intra-arterial Chemotherapy in Pediatric Retinoblastoma.

Phase NA Unknown

36 enrolled

Retinoblastoma

NCT04156347 2023-10-31

Topotecan Episcleral Plaque for Treatment of Retinoblastoma

Phase 1 Unknown

42 enrolled

Retinoblastoma

NCT04455139 2023-10-03

EuRbG2018

Phase 2 Terminated

2 enrolled

Retinoblastoma

NCT03677128 2023-05-09

Mobile Health Case Management System for Reducing Pediatric Treatment Abandonment

LymphoidOther solid neoplasm

75 enrolled 12 charts

Burkitt Lymphoma, Neoplasms, Retinoblastoma, Lymphoma, Large B-Cell, Diffuse

NCT04700514 2023-04-24

Effect of Anesthetic Drugs on Neurocognitive Function in Children With Retinoblastoma Requiring Multiple Anesthetic Exposure - Preliminary Study

Phase NA Unknown

60 enrolled

Retinoblastoma

NCT05080010 2021-10-15

Adjuvant Chemotherapy for High-risk Postenucleation Retinoblastoma

Phase 3 Recruiting

500 enrolled

Retinoblastoma

NCT04990271 2021-08-04

A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma

Phase 2 Unknown

92 enrolled

Retinoblastoma

NCT04383860 2021-06-15

Sutures in Orbital Implants in Retinoblastoma Patients

132 enrolled

Retinoblastoma

NCT04799002 2021-03-16

Topotecan and Melphalan for Retinoblastoma

Phase 3 Recruiting

50 enrolled

CNSGenitourinaryOther solid neoplasmSarcoma

Retinoblastoma

NCT01987596 2020-10-29

Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer

Phase 3 Terminated

23 enrolled 9 charts

Medulloblastoma, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Osteosarcoma, Choroid Plexus Neoplasms

NCT01466855 2020-09-14

IARB1

Phase EARLY_PHASE1 Terminated

36 enrolled

Retinoblastoma

NCT00179920 2020-08-05

Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma

Phase 2 Completed

30 enrolled

Retinoblastoma, Retinal Neoplasms

NCT04429139 2020-06-12

Photodynamic Therapy With Visudyne for Human Retinoblastoma: A Preliminary Study

8 enrolled

Retinoblastoma

NCT01331135 2020-05-29

Aflac ST0901

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

18 enrolled

Astrocytoma, Carcinoma, Renal Cell, Ependymoma, Glioma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Recurrence, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT02116959 2020-04-16

Alternating Systemic Chemotherapy and Intra-Arterial Melphalan (IAM) Chemotherapy in Children With Intra-Ocular Retinoblastoma

Phase 1 Terminated

6 enrolled

Retinoblastoma

NCT02390843 2020-04-03

AflacST1402

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

13 enrolled

Carcinoma, Renal Cell, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT02792036 2020-02-20

Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma

8 enrolled

Retinoblastoma

NCT01293539 2018-11-27

Intra-arterial Chemotherapy for the Treatment of Intraocular Retinoblastoma

Phase 2 Terminated

10 enrolled 8 charts

CNSGastrointestinalLymphoidOther hematologic neoplasmOther solid neoplasm

Retinoblastoma

NCT02933333 2018-10-17

G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor

Phase 4 Unknown

405 enrolled

Lymphoma, Neuroblastoma, Retinoblastoma, Leukemia, Myeloid, Acute, Hepatoblastoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03439397 2018-03-01

RCT of Ballon Technique VS Selective Ophthalmic Artery Infusion For the Retinoblastoma Patients

Phase NA Unknown

496 enrolled

Retinoblastoma

NCT02617862 2018-02-12

PCI Imaging System in Pediatric Ophthalmology

Phase NA Terminated

6 enrolled

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Retinoblastoma

NCT00623077 2017-12-05

MT2004-30: Tomotherapy for Solid Tumors

Phase 1 Terminated

23 enrolled

Familial ependymoma, Astrocytoma, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Optic Nerve Glioma

NCT00003926 2017-11-29

Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors

Phase 1 Terminated

13 enrolled

CNSGastrointestinalGenitourinaryGynecologicOther solid neoplasmSarcoma

Ovarian Germ Cell Cancer, Astrocytoma, Brain Neoplasms, Chordoma, Ependymoma, Glioma, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Ovarian Neoplasms, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Neuroectodermal Tumors, Hepatoblastoma, Desmoplastic Small Round Cell Tumor

NCT00980551 2017-03-03

RELRB1

Phase NA Withdrawn