Clinical Trials

NCT06498648 2026-04-13

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

Phase 1/2 Recruiting

74 enrolled

Phase 2 Active not recruiting

Leiomyosarcoma, Liposarcoma, Sarcoma

NCT03678883 2026-04-03

9-ING-41 in Patients With Advanced Cancers

350 enrolled

BreastCNSGastrointestinalGenitourinaryLymphoidOther hematologic neoplasmSarcomaThoracic

Bone Neoplasms, Breast Neoplasms, Glioma, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Neoplasms, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms, Leukemia-Lymphoma, Adult T-Cell

NCT02945800 2026-04-02

Nab-Paclitaxel and Gemcitabine for Recurrent/Refractory Sarcoma

59 enrolled 11 charts

Recurrence, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma

NCT04383119 2026-03-25

ISG-ARTICLE

100 enrolled

NCT06308419 2026-02-25

A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions

Phase 1 Recruiting

18 enrolled

Leiomyosarcoma, Sarcoma

NCT03123276 2026-02-13

GEMMK

25 enrolled 15 charts

NCT04037527 2026-02-04

Gemcitabine and Docetaxel With Radiation in Adults With Soft Tissue Sarcoma of the Extremities

9 enrolled

NCT07359053 2026-01-22

MAGNATE-S

46 enrolled

NCT03449901 2025-12-11

ADI-PEG 20 in Combination With Gemcitabine and Docetaxel for the Treatment of Soft Tissue Sarcoma, Osteosarcoma, Ewing's Sarcoma, and Small Cell Lung Cancer

98 enrolled 12 charts

NCT04807816 2025-10-02

TARSARC

72 enrolled

Leiomyosarcoma, Neoplasm Metastasis, Sarcoma

NCT02784795 2025-08-21

A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors

BreastGastrointestinalSarcoma

94 enrolled 28 charts

Breast Neoplasms, Colonic Neoplasms, Sarcoma, Cholangiocarcinoma

NCT06114004 2025-06-25

SeliSarc

88 enrolled

NCT05389462 2025-05-22

A Study of Mipasetamab Uzoptirine (ADCT-601) in Participants With Solid Tumors

128 enrolled

GastrointestinalSarcoma

Pancreatic Neoplasms, Sarcoma

NCT02632448 2025-05-02

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

BreastGastrointestinalGynecologicSarcoma

229 enrolled

Breast Neoplasms, Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Recurrence, Sarcoma, Colorectal Neoplasms, Endometrial Neoplasms, Gastrointestinal Stromal Tumors, Triple Negative Breast Neoplasms

NCT04553692 2025-03-28

Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants with Relapsed, Refractory, or Newly Diagnosed Cancers

GastrointestinalLymphoidOther hematologic neoplasmSarcoma

272 enrolled

Chondrosarcoma, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Sarcoma, Colorectal Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute

NCT03997968 2024-12-24

A Phase 1/2 Study of CYT-0851 in B-Cell Malignancies and Advanced Solid Tumors

BreastGastrointestinalGynecologicHead & NeckLymphoidPlasma cellSarcomaThoracic

169 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Head and Neck Neoplasms, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Multiple Myeloma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Lymphoma, Mantle-Cell, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT03009058 2024-11-25

MODULATE

2 enrolled 7 charts

DermatologicSarcoma

Melanoma, Neoplasm Metastasis, Sarcoma

NCT04183062 2024-11-08

BIO-11006 for Osteosarcoma and Ewing's Sarcoma Lung Metastases

Phase 2 Withdrawn

Bone Neoplasms, Sarcoma

NCT03507491 2024-10-04

Nab-paclitaxel in Combination with Gemcitabine for Pediatric Relapsed and Refractory Solid Tumors

CNSGastrointestinalGenitourinarySarcoma

24 enrolled

Neoplasms, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma

NCT04535713 2024-07-05

GALLANT: Metronomic Gemcitabine, Doxorubicin, Docetaxel and Nivolumab for Advanced Sarcoma

260 enrolled

NCT01803152 2024-07-03

Dendritic Cell Vaccine for Children and Adults With Sarcoma

19 enrolled

Bone Neoplasms, Sarcoma

NCT02049905 2024-06-13

Phase 3 Study to Treat Patients With Soft Tissue Sarcomas

Phase 3 Completed

433 enrolled 10 charts

Neoplasm Metastasis, Sarcoma

NCT05093322 2024-06-07

A Study of Surufatinib in Combination With Gemcitabine in Pediatric, Adolescent, and Young Adult Patients With Recurrent or Refractory Solid Tumors

13 enrolled 17 charts

LymphoidSarcoma

Lymphoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma

NCT04595994 2024-01-23

SeliSarc

Phase 1 Recruiting

14 enrolled

NCT04145700 2023-09-13

CAMPFIRE: A Study of Ramucirumab (LY3009806) in Children and Young Adults With Synovial Sarcoma

23 enrolled 15 charts

Sarcoma, Sarcoma, Synovial

NCT02959164 2023-07-28

Decitabine and Gemcitabine for Pancreatic Cancer and Sarcoma

36 enrolled

NCT02797977 2023-06-22

A Phase 1/2 Trial SRA737 in Combination With Gemcitabine and Cisplatin or Gemcitabine Alone in Advanced Cancer Subjects

Classical hematologySarcomaThoracic

153 enrolled

Fanconi Anemia, Sarcoma, Small Cell Lung Carcinoma

NCT04877587 2023-02-22

Gemcitabine With Ascorbate Including Adolescents

Phase EARLY_PHASE1 Withdrawn

Bone Neoplasms, Sarcoma

NCT02511132 2022-12-22

A Two-part Phase IIb Trial of Vigil (Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in Ewing's Sarcoma

22 enrolled 13 charts

Sarcoma, Sarcoma, Ewing

NCT03524898 2022-09-28

NAPAGE: NAb-PAclitaxel and GEmcitabine in Advanced Soft Tissue Sarcoma

39 enrolled

Neoplasms, Sarcoma

NCT01879085 2022-09-21

GemTax

37 enrolled 17 charts

Neoplasm Metastasis, Sarcoma

NCT03810976 2022-06-16

A Study of Eribulin With Gemcitabine in Patients With Advanced Liposarcoma or Leiomyosarcoma

37 enrolled

NCT02659020 2022-05-09

ANNOUNCE 2

310 enrolled 33 charts

NCT05116800 2021-12-07

Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma

Phase 2 Withdrawn

Bone Neoplasms, Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT01532687 2021-09-27

Gemcitabine With or Without Pazopanib in Treating Patients With Refractory Soft Tissue Sarcoma

54 enrolled 12 charts

Chondrosarcoma, Extraskeletal Myxoid, Fibrosarcoma, Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Synovial, Sarcoma, Alveolar Soft Part, Neurofibrosarcoma, Hemangioendothelioma, Epithelioid, Histiocytoma, Malignant Fibrous, Desmoplastic Small Round Cell Tumor

NCT03056599 2021-09-24

Precise Local Injection of Anti-cancer Drugs Using Presage's CIVO Device in Soft Tissue Sarcoma

23 enrolled

NCT04906876 2021-07-28

A Phase 2 Study of 9-ING-41Combined With Chemotherapy in Adolescents and Adults With Advanced Sarcomas

Phase 2 Withdrawn

Bone Neoplasms, Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT02448537 2021-03-03

A Phase II Multi-Strata Study of PM01183 as a Single Agent or in Combination With Conventional Chemotherapy in Metastatic and/or Unresectable Sarcomas

42 enrolled 11 charts

NCT03468075 2020-12-10

Gemcitabine Plus Ascorbate for Sarcoma in Adults

Phase 2 Terminated

10 enrolled 13 charts

Bone Neoplasms, Sarcoma

NCT00860015 2020-08-25

Alimta Plus Gemcitabine for Advanced Sarcoma

12 enrolled 4 charts

NCT01593748 2020-04-06

A Phase II Trial Comparing Gemcitabine and Pazopanib Versus Gemcitabine and Docetaxel for Patients With Advanced Soft Tissue Sarcoma

90 enrolled 12 charts

NCT01574716 2019-08-21

SOURCE

209 enrolled 18 charts

NCT01106872 2018-08-10

Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas

47 enrolled

NCT02331251 2018-07-02

Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer (PembroPlus)

BreastGastrointestinalSarcomaThoracic

81 enrolled

Breast Neoplasms, Pancreatic Neoplasms, Sarcoma, Small Cell Lung Carcinoma

NCT00620295 2017-11-29

Bortezomib and Gemcitabine in Treating Older Patients With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

17 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Osteosarcoma, Uterine Neoplasms, Colorectal Neoplasms, Small Cell Lung Carcinoma

NCT00227669 2016-08-30

Gemcitabine With or Without Docetaxel as Second-Line Therapy in Treating Patients With Metastatic or Relapsed, Unresectable Uterine or Soft Tissue Leiomyosarcoma

90 enrolled

Leiomyosarcoma, Sarcoma

NCT01325558 2016-07-15

A Study of ALT-836 in Combination With Gemcitabine for Locally Advanced or Metastatic Solid Tumors

BreastClassical hematologyGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

30 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Venous Thromboembolism

NCT01719302 2016-06-16

Docetaxel, Gemcitabine and Pazopanib as Treatment for Soft Tissue Sarcoma

6 enrolled

NCT02046304 2016-04-06

PP-Gemcitabine & External Beam Radiation-Sarcomas

41 enrolled