Clinical Trials

65 enrolled

Malignant mesenchymal tumor, Rhabdomyosarcoma, Sarcoma

NCT03114527 2026-05-22

Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)

48 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma

NCT03449108 2026-05-22

LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas

BreastEndocrineGynecologicHead & NeckSarcoma

30 enrolled

Bone Neoplasms, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Giant Cell Tumor of Bone, Histiocytoma, Malignant Fibrous, Triple Negative Breast Neoplasms, Thyroid Carcinoma, Anaplastic

NCT04055753 2026-05-22

Study to Assess TOPO2A as a Biomarker for Sensitivity to Doxorubicin/Doxil in Soft Tissue Sarcoma

24 enrolled

Phase EARLY_PHASE1 Active not recruiting

NCT04634227 2026-05-22

Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)

30 enrolled

Bone Neoplasms, Sarcoma

NCT06904365 2026-05-18

OvAR-Y

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

10 enrolled

Anus Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Colonic Neoplasms, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Rectal Neoplasms, Sarcoma, Stomach Neoplasms, Uterine Neoplasms

NCT03972930 2026-05-12

Hypofractionated Radiotherapy for Soft Tissue Sarcomas

48 enrolled 10 charts

NCT04430725 2026-05-05

Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME Study

GastrointestinalSarcomaThoracic

74 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Sarcoma, Colorectal Neoplasms

NCT04200443 2026-05-01

Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue Sarcoma

96 enrolled 15 charts

Leiomyosarcoma, Sarcoma

NCT04483778 2026-04-28

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

CNSDermatologicGastrointestinalGenitourinaryOther solid neoplasmSarcoma

68 enrolled

Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT03414229 2026-04-23

A Study of Epacadostat, an IDO1 Inhibitor, in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma

30 enrolled 11 charts

NCT01590069 2026-04-21

Aerosolized Aldesleukin in Treating Patients With Lung Metastases

DermatologicGenitourinarySarcoma

70 enrolled

Carcinoma, Renal Cell, Melanoma, Sarcoma, Osteosarcoma

NCT04968106 2026-04-21

Sarcoma, Ichthyosis, X-Linked

NCT01746238 2026-04-17

Bevacizumab/Doxorubicin/Radiation for Sarcoma

14 enrolled

NCT02713269 2026-04-17

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

60 enrolled

Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Sarcoma, Spinal Cord Compression, Thyroid Neoplasms

NCT05099666 2026-04-13

Lurbinectedin + Doxorubicin In Leiomyosarcoma

62 enrolled

NCT05407441 2026-04-13

Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors

49 enrolled

Phase 4 Active not recruiting

Chordoma, Sarcoma, Rhabdoid Tumor

NCT03144206 2026-03-27

Hyperbaric Oxygen Therapy for Soft Tissue Sarcoma Pilot Study

20 enrolled

NCT04420975 2026-03-10

Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

14 enrolled

Leiomyosarcoma, Sarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Neurofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT03418818 2026-03-06

FAZA PET/MRI Sarcoma

70 enrolled

Hypoxia, Sarcoma

NCT00186992 2026-03-04

Radiation Therapy to Treat Musculoskeletal Tumors

202 enrolled 10 charts

Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing

NCT02574728 2026-03-02

AflacST1502

46 enrolled

CNSMyeloidSarcoma

Brain Neoplasms, Carcinoma, Ependymoma, Histiocytosis, Langerhans-Cell, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT04288375 2026-02-20

Dose Reduction of Postoperative Radiation for Soft Tissue Sarcoma of the Arms and Legs

65 enrolled

NCT03474094 2026-02-10

RT-Immune

62 enrolled

NCT05180695 2026-02-10

AMPHISARC

47 enrolled

NCT03628209 2026-02-05

Nivolumab or Nivolumab and Azacitidine in Patients With Recurrent, Resectable Osteosarcoma

21 enrolled

Sarcoma, Osteosarcoma

NCT03077178 2026-01-30

SARCOLD

25 enrolled

NCT04599062 2026-01-29

TVEC and Preop Radiation for Sarcoma (8 ml Dose)

8 enrolled 8 charts

NCT05121545 2026-01-29

ProGRID

11 enrolled

DermatologicSarcoma

Melanoma, Sarcoma

NCT02432963 2026-01-28

Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy

BreastDermatologicGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

11 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Carcinoma, Hepatocellular, Melanoma, Pancreatic Neoplasms, Rectal Neoplasms, Sarcoma, Triple Negative Breast Neoplasms

NCT00902044 2026-01-26

HEROS

36 enrolled

NCT04425967 2026-01-20

SCOPES

168 enrolled

NCT00508443 2026-01-15

Evaluation of a Novel CT-On-Rails or Trilogy Stereotactic Spine Radiotherapy System (SSRS)

BreastDermatologicGastrointestinalLymphoidSarcomaThoracic

150 enrolled

Urogenital Diseases, Breast Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Lymphoma, Melanoma, Neoplasms, Sarcoma, Spinal Diseases, Spinal Neoplasms

NCT00582647 2026-01-15

Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract

DermatologicGastrointestinalSarcoma

6,000 enrolled

Bile Duct Neoplasms, Esophageal Neoplasms, Liver Neoplasms, Melanoma, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms

NCT06660810 2026-01-15

Neoadjuvant Intralesional Injection of Talimogene Laherparepvec

2 enrolled

NCT04616248 2026-01-07

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

BreastDermatologicSarcoma

14 enrolled

Bone Neoplasms, Breast Neoplasms, Carcinoma, Basal Cell, Melanoma, Sarcoma, Osteosarcoma, Carcinoma, Merkel Cell

NCT05075993 2025-12-26

Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors

DermatologicGastrointestinalGynecologicSarcoma

352 enrolled

Uveal Melanoma, Carcinoma, Hepatocellular, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms

NCT04416568 2025-12-17

Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

45 enrolled

Chordoma, Sarcoma, Rhabdoid Tumor

NCT05776667 2025-12-09

Feasibility Trial of Preoperative 5-Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma

16 enrolled

NCT06128863 2025-12-08

EFTISARC-NEO

40 enrolled

NCT02307630 2025-12-04

PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study

7 enrolled

CNSDermatologicSarcoma

Melanoma, Neuroblastoma, Sarcoma

NCT04388839 2025-11-26

Evolutionary Therapy for Rhabdomyosarcoma

12 enrolled

Rhabdomyosarcoma, Sarcoma

NCT03618381 2025-11-20

EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

44 enrolled

Carcinoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

NCT04551430 2025-11-12

Cabozantinib Combined With PD-1 and CTLA-4 Inhibition in Metastatic Soft Tissue Sarcoma

105 enrolled

NCT00996710 2025-11-04

Genomic Structural Variation in Cancer Susceptibility