Clinical Trials

Phase 1/2 Active not recruiting

208 enrolled

DermatologicThoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Skin Neoplasms

NCT04349436 2026-04-22

ARTACUS

69 enrolled

Carcinoma, Carcinoma, Basal Cell, Neoplasms, Skin Neoplasms, Carcinoma, Merkel Cell

NCT06585410 2026-04-22

Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

Phase 3 Recruiting

369 enrolled

Skin Neoplasms

NCT01604889 2026-04-21

A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma

Phase 1/2 Terminated

50 enrolled

Phase 2 Active not recruiting

Melanoma, Neoplasms, Skin Neoplasms

NCT07288203 2026-04-20

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma

100 enrolled

Melanoma, Skin Neoplasms

NCT06947928 2026-04-17

Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma

Phase 2/3 Recruiting

118 enrolled

Neoplasm Metastasis, Skin Neoplasms, Carcinoma, Merkel Cell

NCT06362369 2026-04-13

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

DermatologicGastrointestinalGenitourinaryOther solid neoplasmThoracic

126 enrolled

Turcot syndrome, Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Kidney Neoplasms, Liver Neoplasms, Melanoma, Neoplasm Metastasis, Skin Neoplasms, Colorectal Neoplasms

NCT04657991 2026-04-07

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

Phase 3 Active not recruiting

257 enrolled

Phase NA Active not recruiting

Melanoma, Skin Neoplasms

NCT03737734 2026-04-06

Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia (DaRT)

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Lip Neoplasms, Sarcoma, Kaposi, Skin Neoplasms, Soft Tissue Neoplasms, Tongue Neoplasms

NCT05047094 2026-04-06

Alpha Radiation Emitters Device (DaRT) in Combination With Check Point Inhibitor for the Treatment of Recurrent Unresectable or mHNSCC

48 enrolled

DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Recurrence, Skin Neoplasms

NCT05727904 2026-04-03

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

Phase 3 Recruiting

670 enrolled

Phase EARLY_PHASE1 Completed

Melanoma, Skin Neoplasms

NCT04480645 2026-03-24

CivaDerm(TM) Surface Therapy Pilot Study

10 enrolled

Carcinoma, Basal Cell, Skin Neoplasms

NCT05727839 2026-03-24

Study to Evaluate JCXH-211 as Monotherapy in Patients With Malignant Solid Tumors

Phase 1 Completed

19 enrolled

Neoplasms, Skin Neoplasms

NCT05774600 2026-03-19

Virtual Sun Safe Workplaces Ph II (SSW Works)

543 enrolled 9 charts

Skin Neoplasms

NCT06926075 2026-03-17

ADVICE

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicThoracic

80 enrolled

Breast Neoplasms, Glioblastoma, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Skin Neoplasms

NCT05926960 2026-03-09

PORTSIDE

Phase 2 Terminated

38 enrolled

Phase 4 Not yet recruiting

Melanoma, Skin Neoplasms

NCT07459543 2026-03-09

A Study To Assess the Safety, and Tolerability of Nivolumab + Relatlimab Fixed-Dose Combination (FDC) In Untreated, Unresectable or Metastatic Melanoma Participants In India

30 enrolled

921 enrolled 48 charts 1 FDA

Melanoma, Skin Neoplasms

NCT06171750 2026-03-06

ANCHOR

Phase 1 Recruiting

97 enrolled

DermatologicThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Skin Neoplasms

NCT01909453 2026-02-27

COLUMBUS

Phase 3 Completed

Phase 2 Active not recruiting

Melanoma, Neoplasm Metastasis, Neoplasms, Skin Diseases, Skin Neoplasms

NCT06190951 2026-02-10

A Trial to Learn if Fianlimab and Cemiplimab Are Safe and Work Better Than Anti-PD1 Alone in Adult Participants With Resectable Stage 3 or 4 Melanoma

151 enrolled

Phase 1 Active not recruiting

Melanoma, Skin Neoplasms

NCT05544929 2026-01-06

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

126 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Nasopharyngeal Carcinoma, Anus Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Intestinal Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma, Mesothelioma, Nasopharyngeal Neoplasms, Neoplasms, Ovarian Neoplasms, Rectal Neoplasms, Skin Neoplasms, Thymoma, Thymus Neoplasms, Colorectal Neoplasms, Adenocarcinoma, Clear Cell, Triple Negative Breast Neoplasms

NCT06022029 2025-12-24

ON-5001

Phase 1 Recruiting

168 enrolled

BreastDermatologicGenitourinaryGynecologicHead & NeckLymphoid

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Bites and Stings, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma in Situ, Uterine Cervical Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Neoplasm Metastasis, Neoplasms, Recurrence, Skin Neoplasms, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Triple Negative Breast Neoplasms

NCT03886181 2025-12-08

Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal and Superficial Soft Tissue Neoplasia (DaRT)

Phase NA Terminated

2 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Lip Neoplasms, Sarcoma, Kaposi, Skin Neoplasms, Soft Tissue Neoplasms, Tongue Neoplasms

NCT03889899 2025-12-02

Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia.

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Lip Neoplasms, Sarcoma, Kaposi, Skin Neoplasms, Soft Tissue Neoplasms, Tongue Neoplasms

NCT04540588 2025-12-02

Retreatment With Intratumoral Diffusing Alpha Radiation Emitters

2 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Lip Neoplasms, Recurrence, Sarcoma, Kaposi, Skin Neoplasms, Soft Tissue Neoplasms, Tongue Neoplasms

NCT05323253 2025-12-02

A Clinical Study to Assess the Efficacy and Safety of Alpha DaRT224 for the Treatment of Patients With Recurrent Cutaneous Squamous Cell Carcinoma

86 enrolled

Phase NA Not yet recruiting

Carcinoma, Squamous Cell, Skin Neoplasms

NCT06615635 2025-12-02

DaRT

28 enrolled

Carcinoma, Squamous Cell, Skin Neoplasms

NCT02967692 2025-09-18

COMBI-i

Phase 3 Terminated

568 enrolled 28 charts

Melanoma, Skin Neoplasms

NCT05086692 2025-07-09

ABILITY-1

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

115 enrolled

Turcot syndrome, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Urinary Bladder Neoplasms, Carcinoma, Basal Cell, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Skin Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT05188729 2025-06-18

Open-Label Proof of Concept Study of VP-315 in Basal Cell Carcinoma

Phase 2 Completed

92 enrolled 17 charts

Phase 1 Active not recruiting

Carcinoma, Carcinoma, Basal Cell, Neoplasms, Skin Neoplasms

NCT05704985 2025-05-29

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

39 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Kidney Neoplasms, Neoplasms, Pancreatic Neoplasms, Skin Neoplasms, Colorectal Neoplasms

NCT05608291 2025-05-13

A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery

Phase 3 Active not recruiting

1,564 enrolled

DermatologicGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Melanoma, Skin Neoplasms

NCT04301011 2025-04-23

RAPTOR

Phase 1 Terminated

27 enrolled

Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Melanoma, Mesothelioma, Oropharyngeal Neoplasms, Skin Neoplasms

NCT04774952 2025-04-15

Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors

Phase 1 Completed

58 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Urinary Bladder Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Esophageal Diseases, Esophageal Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Melanoma, Neoplasms, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Hereditary Sensory and Autonomic Neuropathies, Ovarian Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Skin Neoplasms, Thoracic Neoplasms, Uterine Neoplasms, Neoplasms, Squamous Cell

NCT05297565 2025-02-27

CheckMate-6GE

Phase 3 Completed

14 enrolled 8 charts

Melanoma, Skin Neoplasms

NCT04534127 2025-02-07

Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia

56 enrolled

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Lip Neoplasms, Sarcoma, Kaposi, Skin Neoplasms, Soft Tissue Neoplasms, Tongue Neoplasms

NCT03212404 2025-02-03

Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers

272 enrolled 1 FDA

DermatologicGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmThoracic

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Head and Neck Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Neoplasms, Skin Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Carcinoma, Small Cell

NCT05361174 2024-12-05

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

53 enrolled

DermatologicThoracic

Bronchial Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms, Melanoma, Neoplasms, Skin Neoplasms

NCT04068155 2024-11-22

Alpha Radiation Emitters Device for the Treatment of of Malignant Cutaneous Tumors

80 enrolled

Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Eyelid Neoplasms, Lip Neoplasms, Skin Neoplasms

NCT03278340 2024-11-14

SSW-T

2,644 enrolled

Skin Neoplasms

NCT04091672 2024-07-30

RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction

65 enrolled 10 charts

Degloving Injuries, Crush Injuries, Surgical Wound, Cellulitis, Infections, Skin Neoplasms, Wounds, Gunshot, Fasciitis, Necrotizing

NCT05619471 2024-07-25

VISTA

65 enrolled 11 charts

Skin Abnormalities, Skin Diseases, Skin Neoplasms

NCT04337931 2024-02-13

A Study to Evaluate Sotigalimab (APX005M) in Subjects With Unresectable or Metastatic Melanoma

Phase 2 Terminated

45 enrolled 14 charts

Melanoma, Neoplasms, Skin Neoplasms

NCT01856023 2023-12-05

PROCLIVITY02

Phase 4 Terminated

29 enrolled 9 charts

Melanoma, Neoplasm Metastasis, Skin Neoplasms

NCT04977700 2023-11-13

Using Physical Tracking to Predict Sunburn

41 enrolled 16 charts

Phase EARLY_PHASE1 Unknown

Motor Activity, Skin Neoplasms

NCT05932511 2023-08-30

Topical Ascorbic Acid for Treatment of Squamous Cell Skin Cancer

15 enrolled