Clinical Trials

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

192 enrolled 20 charts

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Carcinoma, Small Cell, Small Cell Lung Carcinoma, Prostatic Neoplasms, Castration-Resistant

NCT05814666 2026-01-30

PEMDA-HN

69 enrolled 21 charts

Squamous Cell Carcinoma of Head and Neck

NCT04916002 2025-12-05

A Trial To Find Out If Vidutolimod Together With Cemiplimab Is Safe And If It Works In Adult Participants With Advanced Cancer Or Metastatic Cancer

BreastDermatologicHead & NeckThoracic

77 enrolled 18 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Carcinoma, Merkel Cell, Triple Negative Breast Neoplasms

NCT04854499 2025-11-19

ELEVATE HNSCC

193 enrolled 27 charts

Squamous Cell Carcinoma of Head and Neck

NCT06046482 2025-10-22

Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma

4 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck

NCT04459715 2025-10-08

A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)

Phase 3 Terminated

730 enrolled 40 charts

Squamous Cell Carcinoma of Head and Neck

NCT05061420 2025-09-22

A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With HNSCC (Master Protocol) (Pegathor Head and Neck 204)

59 enrolled 18 charts

Squamous Cell Carcinoma of Head and Neck

NCT03729596 2025-07-31

MGC018 With or Without MGA012 in Advanced Solid Tumors

BreastDermatologicHead & NeckThoracic

143 enrolled 33 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma, Triple Negative Breast Neoplasms

NCT02892201 2025-07-29

Pembrolizumab in HNSCC With Residual Disease After Radiation

9 enrolled 15 charts

Squamous Cell Carcinoma of Head and Neck

NCT03094169 2025-06-11

AVID100 in Advanced Epithelial Carcinomas

BreastHead & NeckThoracic

49 enrolled 19 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Triple Negative Breast Neoplasms

NCT04442126 2025-05-23

A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors

BreastGastrointestinalGynecologicHead & NeckThoracic

52 enrolled 33 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Fallopian Tube Neoplasms, Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT04633278 2025-05-11

CMP-001 in Combination With Pembrolizumab in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

24 enrolled 18 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Head and Neck Neoplasms

NCT03053960 2025-04-30

Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer

Terminated

8 enrolled 5 charts

Squamous Cell Carcinoma of Head and Neck

NCT03829501 2025-04-02

A Phase 1/2, Open-label, Multi-center Study of the Safety and Efficacy of Alomfilimab (KY1044) as Single Agent and in Combination With Anti-PD-L1 (Atezolizumab) in Adult Patients With Selected Advanced Malignancies

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

222 enrolled 49 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasm Metastasis, Pancreatic Neoplasms, Stomach Neoplasms, Triple Negative Breast Neoplasms

NCT02827838 2025-03-17

Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer

Phase EARLY_PHASE1 Terminated

17 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT04032704 2025-03-10

A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

205 enrolled 54 charts

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung, Melanoma, Prostatic Neoplasms, Small Cell Lung Carcinoma

NCT04502888 2025-02-24

Ph1 Study of SL-172154 Administered Intratumorally in Subjects With Squamous Cell Carcinoma of the Head and Neck or Skin

5 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck

NCT04220775 2024-11-07

Bintrafusp Alfa and Stereotactic Body Radiation Therapy for the Treatment of Recurrent or Second Primary Head and Neck Squamous Cell Cancer

3 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck

NCT03153982 2024-10-30

Ruxolitinib in Operable Head and Neck Cancer

16 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck

NCT04428333 2024-10-09

INDUCE-4

Phase 3 Terminated

117 enrolled 33 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02554812 2024-07-30

JAVELIN Medley

BreastDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

409 enrolled 108 charts

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Stomach Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT04628780 2024-07-29

Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors

GastrointestinalGenitourinaryGynecologicHead & NeckThoracic

37 enrolled 32 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Neoplasm Metastasis, Ovarian Neoplasms, Colorectal Neoplasms

NCT03601507 2024-04-17

Alpelisib in Treating Participants With Transorally Resectable HPV-Associated Stage I-IVA Oropharyngeal Cancer

9 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck

NCT04144140 2024-03-07

Study of Intratumorally Administered Stimulator of Interferon Genes (STING) Agonist E7766 in Participants With Advanced Solid Tumors or Lymphomas - INSTAL-101

BreastDermatologicGastrointestinalHead & NeckLymphoid

24 enrolled 29 charts

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Breast Neoplasms, Lymphoma, Melanoma, Colorectal Neoplasms

NCT04634825 2023-12-20

Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer

62 enrolled 24 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03525392 2023-12-12

Study to Evaluate the Safety and Activity (Including Distribution) of 177Lu-3BP-227 in Subjects With Solid Tumours Expressing Neurotensin Receptor Type 1.

GastrointestinalHead & NeckSarcoma

14 enrolled 20 charts

Squamous Cell Carcinoma of Head and Neck, Bone Neoplasms, Neoplasm Metastasis, Recurrence, Stomach Neoplasms, Colorectal Neoplasms

NCT04193293 2023-09-21

A Study of Duvelisib in Combination With Pembrolizumab in Head and Neck Cancer

2 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02524275 2023-09-08

Docetaxel and Capecitabine With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

14 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck

NCT04424641 2023-07-25

A Study on the Safety of GEN1044 (DuoBody®-CD3x5T4) in Patients With Malignant Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

48 enrolled 20 charts

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Prostatic Neoplasms, Uterine Neoplasms, Triple Negative Breast Neoplasms

NCT03740100 2023-07-14

HNSCC

8 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis

NCT01824823 2023-06-28

Afatinib After Chemoradiation and Surgery in Treating Patients With Stage III-IV Squamous Cell Carcinoma of the Head and Neck at High-Risk of Recurrence

3 enrolled 6 charts

Squamous Cell Carcinoma of Head and Neck

NCT02488629 2023-06-27

Study of SCB01A in Patient With Head and Neck Cancer

5 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck

NCT03522584 2023-06-12

Durvalumab, Tremelimumab and Hypofractionated Radiation Therapy in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

6 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck

NCT03020823 2023-06-05

To Evaluate the Efficacy and Safety of SCB01A in Subjects With r/m Squamous Cell Head and Neck Cancer

10 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02345330 2023-05-15

Trial of pIL-12 Electroporation in Squamous Cell Carcinoma of the Head and Neck (IL12HNSCC)

4 enrolled 6 charts

Squamous Cell Carcinoma of Head and Neck

NCT03823131 2023-05-09

Optimizing Antitumor Immunity Using Plasmid Electroporation, Pembrolizumab, and Epacadostat

14 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck

NCT03254927 2023-04-03

A Study of CDX-3379 and Cetuximab and in Patients With Advanced Head and Neck Squamous Cell Carcinoma

30 enrolled 17 charts

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04034225 2023-03-24

Addition of SNS-301 to Checkpoint Inhibitor Treatment in Metastatic/Recurrent SCCHN

25 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck

NCT02917629 2023-03-08

ACTOplus Met XR in Treating Patients With Stage I-IV Oral Cavity or Oropharynx Cancer Undergoing Definitive Treatment

6 enrolled 22 charts

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03435640 2023-03-08

REVEAL

BreastDermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

64 enrolled 22 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Melanoma, Neoplasm Metastasis, Recurrence, Sarcoma, Colorectal Neoplasms, Carcinoma, Merkel Cell, Triple Negative Breast Neoplasms

NCT02834247 2023-02-08

A Study of TAK-659 in Combination With Nivolumab in Participants With Advanced Solid Tumors

BreastHead & NeckThoracic

41 enrolled 24 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Triple Negative Breast Neoplasms

NCT04969861 2023-01-12

BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)

Phase 2/3 Terminated

1 enrolled 6 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03258008 2022-12-16

Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer

3 enrolled 7 charts

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT01891695 2022-10-12

OPSCC N0 Nodal Control With Reduced IMRT

Phase NA Terminated

1 enrolled 4 charts