Announcements Trials
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Phase

Phase 2 1Phase 1/2 1Phase 1 1

Status

Completed 2Terminated 1

Sponsor Class

OTHER 2INDUSTRY 1

Study Type

Interventional 3

Sponsor

Cancer Type

Head & Neck 3

Conditions

Breast Neoplasms 22Neoplasm Metastasis 15Carcinoma, Non-Small-Cell Lung 7Glioblastoma 6Colorectal Neoplasms 5Triple Negative Breast Neoplasms 4Recurrence 4Ovarian Neoplasms 4Lymphoma, Mantle-Cell 4Lymphoma, Follicular 4Endometrial Neoplasms 4Brain Neoplasms 4Squamous Cell Carcinoma of Head and Neck 3Prostatic Neoplasms 3Pancreatic Neoplasms 3Neoplasms 3Lymphoma, Large B-Cell, Diffuse 3Lung Neoplasms 3Hereditary Sensory and Autonomic Neuropathies 3Head and Neck Neoplasms 3Solid Tumors 2Melanoma 2Lymphoma 2Leukemia, Myeloid, Acute 2Leukemia, Lymphocytic, Chronic, B-Cell 2Esophageal Neoplasms 2Waldenstrom Macroglobulinemia 1Unspecified Adult Solid Tumor, Protocol Specific 1Treatment for Metastatic or Locally Advanced Cervical Cancer 1Tongue Neoplasms 1

Interventions

Cisplatin 274pembrolizumab 229Radiotherapy 166Cetuximab 163Carboplatin 122Docetaxel 109Paclitaxel 94Fluorouracil 94Nivolumab 84Radiotherapy, Intensity-Modulated 78Magnetic Resonance Spectroscopy 39durvalumab 35Radiation 32Surgical Procedures, Operative 31Drug Therapy 30Radiosurgery 25Erlotinib Hydrochloride 25Biopsy 25Albumin-Bound Paclitaxel 24130-nm albumin-bound paclitaxel 24Taxes 23Platinum 22Specimen Handling 21tislelizumab 201,2-diaminocyclohexaneplatinum II citrate 20Cyclophosphamide 19Capecitabine 19tremelimumab 18Ipilimumab 18Gemcitabine 18

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
Interventional × Squamous Cell Carcinoma of Head and Neck × NVP-BKM120 × Clear all
NCT02113878 2024-11-05

Phase Ib Study of BKM120 With Cisplatin and XRT in High Risk Locally Advanced Squamous Cell Cancer of Head and Neck

Dana-Farber Cancer Institute

Phase 1 Completed
23 enrolled 22 charts
Head & Neck

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Nasopharyngeal Neoplasms

NCT01816984 2021-10-05

PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

University of Chicago

Phase 1/2 Completed
12 enrolled 11 charts
Head & Neck

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT01852292 2018-07-24

Study of Efficacy and Safety of Buparlisib (BKM120) Plus Paclitaxel Versus Placebo Plus Paclitaxel in Recurrent or Metastatic Head and Neck Cancer Previously Pre-treated With a Platinum Therapy

Novartis

Phase 2 Terminated
157 enrolled 22 charts
Head & Neck

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

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