Clinical Trials

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms

NCT06980038 2026-05-13

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

44 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Laryngeal Neoplasms, Mouth Neoplasms

NCT04671667 2026-05-08

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

188 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06223568 2026-04-28

Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer

70 enrolled

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms

NCT06161545 2026-04-08

Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma

40 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT00939627 2026-03-10

Phase II Randomized Trial of the Combination of Cetuximab and Sorafenib or Single Agent Cetuximab

55 enrolled 10 charts

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT05996523 2025-10-03

Phase II Trial of Immunotherapeutic HPV Vaccine PRGN-2009 With Pembrolizumab Before Standard Treatment in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal Cancer

16 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT02917629 2023-03-08

ACTOplus Met XR in Treating Patients With Stage I-IV Oral Cavity or Oropharynx Cancer Undergoing Definitive Treatment

Phase 2 Terminated

6 enrolled 22 charts

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00084682 2021-03-05

Depsipeptide in Unresectable Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

14 enrolled 6 charts

Squamous Cell Carcinoma of Head and Neck

NCT01696955 2018-12-19

Cetuximab With or Without Tivantinib in Treating Patients With Head and Neck Cancer That Is Recurrent, Metastatic, or Cannot Be Removed by Surgery

81 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck

NCT00409565 2017-10-20

A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer

48 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT02196168 2017-05-03

Cisplatin With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

Phase 2 Terminated

6 enrolled 9 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT01267240 2017-04-14

Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer

Phase 2 Terminated

25 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck

NCT01256385 2017-03-27

MAESTRO HN

86 enrolled 11 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT00095628 2017-03-06

SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

21 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms

NCT02007200 2016-10-24

Soy Isoflavones in Preventing Head and Neck Cancer Recurrence in Patients With Stage I-IV Head and Neck Cancer Undergoing Surgery

55 enrolled 8 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT00337129 2015-08-25

S0618 E7389 in Treating Patients With Metastatic or Recurrent Head and Neck Cancer

42 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00458978 2015-05-05

Cediranib Maleate in Treating Patients With Recurrent or Newly Diagnosed Metastatic Head and Neck Cancer

6 enrolled

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT00114283 2015-04-15

Lapatinib Ditosylate in Treating Patients With Metastatic or Recurrent Head and Neck Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT00507767 2014-10-01

Dasatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

15 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Salivary Gland Neoplasms, Tongue Neoplasms

NCT00387335 2014-07-25

Sunitinib in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer

22 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck

NCT00103259 2014-05-23

Bortezomib With or Without Irinotecan in Treating Patients With Locally Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

71 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT00492089 2014-05-09

Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer

11 enrolled 7 charts

CNSHead & Neck

Hemangiopericytoma, Malignant, Squamous Cell Carcinoma of Head and Neck, Astrocytoma, Brain Neoplasms, Ependymoma, Glioma, Meningioma, Neoplasms, Oligodendroglioma, Pinealoma, Radiation Injuries, Salivary Gland Neoplasms, Choroid Plexus Neoplasms, Esthesioneuroblastoma, Olfactory

NCT00513435 2014-04-30

Saracatinib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

9 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT00098631 2014-01-07

Lapatinib in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer

88 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT00004094 2014-01-06

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Advanced Cancer of the Mouth, Pharynx, or Larynx

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00003856 2013-12-19

Photodynamic Therapy in Treating Patients With Recurrent, Refractory, or Second Primary Head and Neck Cancer That Cannot Be Treated With Surgery or Radiation Therapy

75 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT00334997 2013-12-19

Endoscopic Surgery or Radiation Therapy in Treating Patients With Stage 0, Stage I, or Stage II Laryngeal Cancer of the Glottis

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Neoplasms

NCT00022217 2013-12-18

Cisplatin-Epinephrine Injectable Gel Plus Paclitaxel and Carboplatin in Treating Patients With Recurrent Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT00003257 2013-12-04

Gene Therapy in Treating Patients With Recurrent Head and Neck Cancer

39 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00637637 2013-08-12

External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmSarcomaThoracic

60 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Thyroid Cancer, Papillary, Anus Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Burkitt Lymphoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Hodgkin Disease, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Mouth Neoplasms, Mycosis Fungoides, Nasopharyngeal Neoplasms, Neoplasms, Wilms Tumor, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Parathyroid Neoplasms, Penile Neoplasms, Pheochromocytoma, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sezary Syndrome, Stomach Neoplasms, Tongue Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Endometrial Neoplasms, Lymphoma, Large-Cell, Anaplastic, Adenocarcinoma, Follicular, Adrenocortical Carcinoma, Esthesioneuroblastoma, Olfactory, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Histiocytoma, Malignant Fibrous, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Dendritic Cell Sarcoma, Interdigitating

NCT00003580 2013-06-26

Amifostine to Treat Side Effects of Treatment in Patients Receiving Radiation Therapy and Cisplatin for Advanced Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Radiation Injuries, Drug-Related Side Effects and Adverse Reactions

NCT00019331 2013-06-20

Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors