Clinical Trials

29 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT04858269 2026-06-01

First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients

32 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT05039801 2026-06-01

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

DermatologicGynecologicHead & NeckSarcoma

54 enrolled

Squamous Cell Carcinoma of Head and Neck, Chondrosarcoma, Melanoma, Ovarian Neoplasms, Endometrial Neoplasms

NCT07392580 2026-06-01

Intralesional Chemotherapy (IC): Cisplatin + Epinephrine

20 enrolled

Phase 2 Enrolling by invitation

Squamous Cell Carcinoma of Head and Neck

NCT07618624 2026-06-01

BRIDGE

42 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06485778 2026-05-29

A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell Carcinoma

24 enrolled

Classical hematologyHead & Neck

Squamous Cell Carcinoma of Head and Neck

NCT06648096 2026-05-27

AFAN

Phase 1/2 Recruiting

25 enrolled

Squamous Cell Carcinoma of Head and Neck, Fanconi Anemia

NCT05294900 2026-05-26

NEOS

79 enrolled 6 charts

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT06308913 2026-05-26

Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma

10 enrolled

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis

NCT06528353 2026-05-26

SCREEN-HPV

10,000 enrolled

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Head and Neck Neoplasms

NCT07606638 2026-05-26

Effectiveness of Opioid vs Pregabalin Plus Naproxen Sodium in Pain Management of Oral Cancer Patients

Phase NA Enrolling by invitation

98 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT02254278 2026-05-22

Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer

316 enrolled 31 charts

Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT02308072 2026-05-22

ORCA-2

Phase 1 Completed

16 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT03336606 2026-05-22

Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma

Phase 1 Completed

13 enrolled

DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Melanoma, Neoplasms, Squamous Cell

NCT03646461 2026-05-22

Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC

Phase 2 Terminated

5 enrolled 9 charts

BreastHead & NeckLymphoid

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03789097 2026-05-22

Vaccination With Flt3L, Radiation, and Poly-ICLC

Phase 1/2 Completed

17 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Carcinoma, Lymphoma, Lymphoma, Non-Hodgkin

NCT04169074 2026-05-22

Immune Modulation by Abemaciclib in Head and Neck Squamous Cell Carcinoma (HNSCC). (AIM Trial)

Phase 2 Terminated

7 enrolled 14 charts

Phase NA Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT05119036 2026-05-22

Adjuvant Treatment Deintensification After Transoral Surgery for Human Papillomavirus-Positive Squamous Cell Carcinoma

83 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck

NCT07405086 2026-05-22

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

Phase 4 Recruiting

160 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT07601737 2026-05-22

Nimotuzumab Combined With PD-1 Inhibitors and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

182 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06855212 2026-05-20

Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC

22 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07264075 2026-05-20

ILLUMINE

Phase 3 Recruiting

780 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07513389 2026-05-20

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

36 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT05743569 2026-05-19

3D Specimen Maps for RT Planning

Active not recruiting

13 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07497607 2026-05-18

REDUCE-30

31 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT03650764 2026-05-15

Ramucirumab + Pembrolizumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Phase 1/2 Completed

43 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07580300 2026-05-15

PRORADNOR-RCT

Phase 3 Recruiting

400 enrolled

Phase 2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07589049 2026-05-15

GATEWAY

42 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04848116 2026-05-14

Spark2

24 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05278039 2026-05-14

Training Swallowing Initiation During Expiration

Phase NA Completed

88 enrolled

Squamous Cell Carcinoma of Head and Neck, Deglutition Disorders, Head and Neck Neoplasms

NCT02841748 2026-05-13

A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study

100 enrolled 13 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04369937 2026-05-13

HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for "Intermediate Risk" HPV-16-associated Head and Neck Squamous Cell Carcinoma

18 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck

NCT05791149 2026-05-13

EPSACO

Phase NA Recruiting

60 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07172256 2026-05-13

CUE-101with Pembrolizumab for Locally Advanced HPV+HNSCCs

Squamous Cell Carcinoma of Head and Neck

NCT07203911 2026-05-13

SURGIO

Phase NA Recruiting

150 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Tongue Neoplasms

NCT07584499 2026-05-13

MRG003

CNSGenitourinaryHead & NeckSarcoma

51 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Rhabdoid Tumor

NCT05420948 2026-05-12

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06747390 2026-05-12

856397

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Oropharyngeal Neoplasms

NCT07149207 2026-05-12

Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

Phase NA Not yet recruiting

Margins of Excision, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms

NCT07579507 2026-05-12

HOPES

150 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06992427 2026-05-11

HOPE

Phase 3 Recruiting

228 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07217028 2026-05-11

Study Evaluating [18F]NOTA-ABY030 for Safety and Tolerability of Indeterminate Primary and/or Metastatic Disease in Head and Neck Squamous Cell Carcinoma

25 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Neoplasms

NCT07567235 2026-05-11

Clinical Study of CFH Protein Via Ice Microneedles for Radiation-Induced Skin Fibrosis

9 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07572864 2026-05-11

Neoadjuvant ICI and Mitochondrial Vaccine for Resectable HNSCC

9 enrolled