Clinical Trials

24 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07441681 2026-05-04

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

454 enrolled

Phase 2/3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07535567 2026-04-30

NimoBenSeq

386 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07554768 2026-04-28

RAIN-HNSCC

36 enrolled

Phase 1/2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07552558 2026-04-27

Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)

45 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Jaw Neoplasms, Laryngeal Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Tongue Neoplasms

NCT07545083 2026-04-22

Neoadjuvant Becotatug Vedotin Plus Pucotenlimab in Locally Advanced Oral and Oropharyngeal Squamous Cell Carcinoma (OSCC)

26 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07361133 2026-04-16

Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Neoplasm Metastasis, Recurrence

NCT07529769 2026-04-14

AID-OraL

Not yet recruiting

5,000 enrolled

Squamous Cell Carcinoma of Head and Neck, Disease, Mouth Neoplasms

NCT07529873 2026-04-14

N'FORCE

131 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07513324 2026-04-07

Risk-adapted Therapy in HPV-positive Oropharyngeal Cancer Using Circulating Tumor (ct) HPV DNA Profiling (ReACT 2.0)

116 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07514767 2026-04-07

NOCANO

Squamous Cell Carcinoma of Head and Neck

NCT07509099 2026-04-03

Cetuximab Combined With Pembrolizumab or Finotonlimab and Chemotherapy in R/M HNSCC

316 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07507058 2026-04-02

Hypofractionated Radiotherapy for Postoperative Intermediate-Risk Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT07241273 2026-03-24

SELECT-FR

128 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT07491783 2026-03-24

Nano-Carbon Iron Suspension Injection Combined With Radiotherapy for Solid Tumors Phase II Clinical Trial

52 enrolled

Head & NeckSarcoma

Squamous Cell Carcinoma of Head and Neck, Sarcoma

NCT06876038 2026-03-19

Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions

65 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma in Situ, Leukoplakia, Oral, Mouth Neoplasms, Lichen Planus, Oral

NCT07471009 2026-03-13

SPAR

Not yet recruiting

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Neoplasms

NCT07460765 2026-03-10

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

40 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasms, Squamous Cell

NCT07432087 2026-02-25

Camrelizumab Combined With EGFR Monoclonal Antibody or Chemotherapy for Perioperative Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

246 enrolled

Phase 1/2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07428148 2026-02-23

Lattice-Based Radiotherapy and Chemoimmunotherapy for Oropharyngeal Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT07413627 2026-02-18

BaReTox

70 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT07418034 2026-02-18

SAVED

132 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT07090070 2026-02-17

p53 RCT

171 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07398664 2026-02-10

H101 Plus TACE for r/m HNSCC

20 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07400094 2026-02-10

NeoCamre-HN

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms, Mouth Neoplasms

NCT07392580 2026-02-06

Intralesional Chemotherapy (IC): Cisplatin + Epinephrine

20 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07393477 2026-02-06

Neoadjuvant Becotatug Vedotin Plus Pucotenlimab and Cisplatin for Locally Advanced Head and Neck Squamous Cell Carcinoma

30 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07381075 2026-02-02

A Phase II Clinical Trial of Anti-EGFR Antibody-drug Conjugate (ADC) Combined With or Without Immune Checkpoint Inhibitors in the Neoadjuvant Treatment of Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma

120 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07214987 2026-01-30

PDT For Induction Therapy For Head And Neck Cancer

26 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT07379424 2026-01-30

A Single-arm, Phase II, Multi-center Clinical Trial of Sintilimab During the Perioperative Period in Patients With Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma

37 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07335380 2026-01-29

Lattice-Based Radiotherapy and Chemo-Immunotherapy for Oral Cavity Squamous Cell Carcinoma

30 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07371897 2026-01-28

SHINE

154 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07354984 2026-01-21

PIONEER-HN

30 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07320690 2026-01-06

Neo-Margin

356 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07306546 2025-12-29

Effectiveness of Hydrogen Water Intervention on Acute Oral Inflammation, Oral Microbiota, and Pain Following Free Flap Reconstruction in Patients With Oral Cancer

36 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Pain, Postoperative

NCT07216833 2025-10-15

Decitabine and Nivolumab in Participants With Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

15 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07168785 2025-09-11

[18F]-AraG PET Imaging in LA HNSCC

5 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07137858 2025-08-22

Adebrelimab Combined With Carboplatin and Albumin-bound Taxanol in the Treatment of Resectable Locally Advanced Oral Squamous Cell Carcinoma Cardiac, Randomized, Phase II Exploratory Study

70 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07127614 2025-08-17

Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell Carcinoma

Not yet recruiting

25 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07090707 2025-07-29

PD-1 Inhibitor Therapy Versus Radiotherapy in MPR Patients With Locally Advanced HNSCC After Neoadjuvant Immunochemotherapy (HNC-SYSU-006)

Squamous Cell Carcinoma of Head and Neck

NCT07079410 2025-07-23

OSCC

Squamous Cell Carcinoma of Head and Neck

NCT05423197 2025-07-16

89Zr-Panitumumab for Assessment of Suspected Metastatic Lesions on 18F-FDG-PET/CT in HNSCC

Phase EARLY_PHASE1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07028918 2025-06-19

NCLDR

35 enrolled

Acidemia, isovaleric, Squamous Cell Carcinoma of Head and Neck

NCT06957938 2025-05-08

Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma

168 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms

NCT06861712 2025-04-25

Chemoimmunotherapy With or Without SBRT Before Surgery for Locally Advanced Oral and Oropharyngeal Cancer