Clinical Trials Browser

Terminated × OTHER × Squamous Cell Carcinoma of Head and Neck × Clear all

NCT03646461 2026-05-22

Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC

Phase 2 Terminated

5 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04169074 2026-05-22

Immune Modulation by Abemaciclib in Head and Neck Squamous Cell Carcinoma (HNSCC). (AIM Trial)

Phase 2 Terminated

7 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT03799445 2026-04-30

Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma

Phase 2 Terminated

37 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms

NCT02819752 2026-04-09

PEACH

Phase 1 Terminated

3 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT06110195 2026-03-31

Study of Xevinapant With Radiation and Chemotherapy for Patients With Head and Neck Cancer

Phase 1 Terminated

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03386357 2026-03-27

Radiotherapy With Pembrolizumab in Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)

Phase 2 Terminated

115 enrolled 15 charts

Squamous Cell Carcinoma of Head and Neck

NCT05316688 2026-02-25

A Fluorescent Tumor Marking Agent, Tozuleristide, for Imaging Oral Cavity Squamous Cell Cancer and High-Grade Oral Cavity Dysplasia During Surgery

Phase 1/2 Terminated

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT04862455 2026-01-23

NBTXR3, Radiation Therapy, and Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Cancer

Phase 2 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT04801472 2026-01-05

OPPIDOM

Phase NA Terminated

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04445064 2025-12-16

HN1901

Phase 2 Terminated

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT06046482 2025-10-22

Phase II Trial of Magrolimab and Cetuximab With Pembrolizumab or Docetaxel for Recurrent/Metastatic Head Neck Squamous Cell Carcinoma

Phase 2 Terminated

4 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck

NCT06338657 2025-09-16

FID-007 Followed by Standard of Care Surgery in Head and Neck Cancer

Phase 1 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT02892201 2025-07-29

Pembrolizumab in HNSCC With Residual Disease After Radiation

Phase 2 Terminated

9 enrolled 15 charts

Squamous Cell Carcinoma of Head and Neck

NCT05714553 2025-07-18

NUC-3373 in Combination With Other Agents in Patients With Advanced Solid Tumours

Phase 1/2 Terminated

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Esophageal Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT05930938 2025-05-09

XXL_2022-01

Phase 3 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT03053960 2025-04-30

Helical CT, PET/CT, MRI, and CBCT Alone or in Combination in Predicting Jaw Invasion in Patients With Oral Cancer

8 enrolled 5 charts

Squamous Cell Carcinoma of Head and Neck

NCT05322135 2025-04-09

A Pilot Study of Glutamine PET Imaging of Head and Neck Squamous Cell Carcinoma

Phase EARLY_PHASE1 Terminated

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02827838 2025-03-17

Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer

Phase EARLY_PHASE1 Terminated

17 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT04588038 2025-02-14

NT-I7 for the Treatment of Recurrent Squamous Cell Carcinoma of Head and Neck Undergoing Surgery

Phase 1 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT05457478 2025-01-24

The Use of "Smart" Body-Weight Scales for Weight and Nutritional Monitoring in Patients With Head and Neck Cancer Undergoing Radiation Therapy

Phase NA Terminated

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04220775 2024-11-07

Bintrafusp Alfa and Stereotactic Body Radiation Therapy for the Treatment of Recurrent or Second Primary Head and Neck Squamous Cell Cancer

Phase 1/2 Terminated

3 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck

NCT03153982 2024-10-30

Ruxolitinib in Operable Head and Neck Cancer

Phase 2 Terminated

16 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck

NCT03601507 2024-04-17

Alpelisib in Treating Participants With Transorally Resectable HPV-Associated Stage I-IVA Oropharyngeal Cancer

Phase 2 Terminated

9 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck

NCT04624113 2024-02-21

Tazemetostat and Pembrolizumab in Patients With Pembrolizumab- or Nivolumab-Resistant, Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma

Phase 1 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT03618134 2023-11-18

Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner

Phase 1/2 Terminated

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms

NCT02524275 2023-09-08

Docetaxel and Capecitabine With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

Phase 2 Terminated

14 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck

NCT03740100 2023-07-14

HNSCC

Phase 2 Terminated

8 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis

NCT03522584 2023-06-12

Durvalumab, Tremelimumab and Hypofractionated Radiation Therapy in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Phase 1/2 Terminated

6 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck

NCT03823131 2023-05-09

Optimizing Antitumor Immunity Using Plasmid Electroporation, Pembrolizumab, and Epacadostat

Phase 2 Terminated

14 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck

NCT04110249 2023-04-10

Photoacoustic Imaging for Measuring Tumors and Normal Tissue in Patients With Head and Neck Cancer

Phase NA Terminated

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms

NCT01827709 2023-04-03

Pathological Validation of Functional Imaging in Head and Neck Squamous Cell Carcinoma

Phase NA Terminated

Squamous Cell Carcinoma of Head and Neck, Hypoxia, Head and Neck Neoplasms

NCT02582008 2023-03-22

Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy

Phase EARLY_PHASE1 Terminated

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma

NCT03258008 2022-12-16

Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer

Phase 2 Terminated

3 enrolled 7 charts

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT03513042 2022-12-06

ERM-PT-HNSCC

Squamous Cell Carcinoma of Head and Neck, Hypoxia, Head and Neck Neoplasms

NCT01891695 2022-10-12

OPSCC N0 Nodal Control With Reduced IMRT

Phase NA Terminated

1 enrolled 4 charts

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT03862066 2022-08-11

Memory Phenotype and PD-1 Inhibition Response in Oral Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03090412 2022-06-02

Photodynamic Therapy With HPPH Compared to Standard of Care Surgery in Treating Patients With Oral Cavity Cancer

Phase 2 Terminated

2 enrolled 11 charts

Squamous Cell Carcinoma of Head and Neck

NCT04428047 2022-04-06

ICING

Phase 2 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT00566540 2021-11-26

Ph 2 Intensification Regimen for Previously Untreated, Resectable, Advanced Squamous Cell Cancer

Phase 2 Terminated

11 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02438995 2021-11-03

Super-Selective Intraarterial Infusion of Cetuximab (Erbitux) With or Without Radiation Therapy for the Treatment of Unresectable Recurrent Squamous Cell Carcinoma of the Head and Neck

Phase 1 Terminated

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT01895829 2021-09-21

Ferumoxytol - Iron Oxide Nanoparticle Magnetic Resonance Dynamic Contrast Enhanced MRI

Phase EARLY_PHASE1 Terminated

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02177838 2021-04-21

Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer

Phase NA Terminated

8 enrolled 9 charts

Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT02822482 2021-03-29

COPAN-ORL06

Phase 1/2 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT03655444 2020-12-03

Abemaciclib + Nivolumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma That Progressed or Recurred Within Six Months After Platinum-based Chemotherapy

Phase 1/2 Terminated

6 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck

NCT03276819 2020-10-08

UMBRELLA

Phase NA Terminated

Squamous Cell Carcinoma of Head and Neck

NCT02464137 2020-08-20

HYDRA

Phase 1 Terminated

Squamous Cell Carcinoma of Head and Neck

NCT01192815 2020-05-12

Erlotinib Hydrochloride and Radiation Therapy in Stage III-IV Squamous Cell Cancer of the Head and Neck

Phase 2 Terminated

2 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck

NCT02236936 2020-05-01

AGMT_HNO_PN

Phase 3 Terminated

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Hyperphagia, Laryngeal Diseases

NCT03463161 2020-01-27

ORKA

Phase 2 Terminated

2 enrolled 5 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02429089 2020-01-09

CETLEE011

Phase 1 Terminated

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence