Clinical Trials Browser

Observational × Squamous Cell Carcinoma of Head and Neck × Clear all

NCT06885424 2026-05-20

DESCENT-1

Enrolling by invitation

BreastGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Kidney Neoplasms, Mesothelioma, Ovarian Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT05743569 2026-05-19

3D Specimen Maps for RT Planning

Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06094829 2026-05-05

DEMO

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT05117775 2026-05-01

HNC-TACTIC

10,000 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05520099 2026-04-29

ELEPHAS-02

Active not recruiting

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Skin Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT04564989 2026-04-28

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT06356272 2026-04-22

Oropharynx (OPX) Biomarker Trial

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Head and Neck Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms, Thyroid Neoplasms

NCT07417605 2026-04-22

POLARIS

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07532928 2026-04-16

A Bidirectional Study of Individualized Postoperative Adjuvant Treatment Decision Model for Locally Advanced Head and Neck Squamous Cell Carcinoma Based on Multimodal Dynamic Data

Enrolling by invitation

Squamous Cell Carcinoma of Head and Neck

NCT07529769 2026-04-14

AID-OraL

Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Disease, Mouth Neoplasms

NCT06163534 2026-04-06

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

Squamous Cell Carcinoma of Head and Neck, Neoplasms

NCT07511413 2026-04-06

GALENOS 1

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Lung Neoplasms, Sarcopenia

NCT07512921 2026-04-06

BIOMATCH

Squamous Cell Carcinoma of Head and Neck

NCT05539638 2026-03-17

The Role of Circulating Tumour DNA in Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck

NCT07471009 2026-03-13

SPAR

Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasms

NCT06947668 2026-03-12

DoIT_Neck

Squamous Cell Carcinoma of Head and Neck

NCT04696744 2026-03-11

CTCO

Squamous Cell Carcinoma of Head and Neck, Neoplastic Cells, Circulating, Oropharyngeal Neoplasms

NCT07448727 2026-03-04

PEMBRO-PET

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05296135 2026-02-27

PREDAPT-HNSCC2

Squamous Cell Carcinoma of Head and Neck

NCT04305366 2026-02-24

MicroRNA Markers in Head and Neck Cancers

Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT06678724 2026-02-24

Establishment of a Microfluidic Based Liquid Biopsy Platform for Recurrent/Metastatic Head and Neck Cancers Prognostication Using NK Cell IFN-γ Expression and CTM Correlation With DS-SACA Chip

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplastic Cells, Circulating

NCT04151134 2026-02-12

MOSES

Active not recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07394842 2026-02-06

HN-ORAL-RT

Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Dental Caries, Head and Neck Neoplasms, Periodontal Diseases, Xerostomia

NCT05522881 2026-01-20

The Registry Study of Genetic Alterations of Oropharyngeal Cancer in Taiwan

Squamous Cell Carcinoma of Head and Neck

NCT07343271 2026-01-15

DECT-CEco

Squamous Cell Carcinoma of Head and Neck

NCT07337122 2026-01-13

Collagen Matrix in Oral Cancer Surgery

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03712566 2026-01-08

MASST

Active not recruiting

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Neoplasm Metastasis, Neoplasms

NCT05482880 2026-01-06

Decisional Conflicts, Health-related QoL and Satisfaction With Care in High-risk cSCC in the Head-neck Region

DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Skin Neoplasms, Patient Satisfaction

NCT04490564 2025-12-30

Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood and Primary Tumor in HNSCC/NSCLC/Melanoma

DermatologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT06606028 2025-12-12

Tumor-Informed ctDNA Testing for MRD Following Treatment of Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06730412 2025-12-04

Clear-HPVca

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Neoplasm, Residual

NCT07246759 2025-11-24

NEUTROFLOW

Not yet recruiting

BreastDermatologicGenitourinaryHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Melanoma, Triple Negative Breast Neoplasms

NCT06592716 2025-11-18

Can Recurrence of Cancer in the Oropharynx be Detected by Blood Samples?

Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Oropharyngeal Neoplasms, Recurrence

NCT00898638 2025-10-28

Tissue Sample Collection From Patients With Head and Neck Cancer and From Healthy Participants

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms, Esthesioneuroblastoma, Olfactory

NCT01644786 2025-10-02

The Head and Neck Tumor Biobank

Squamous Cell Carcinoma of Head and Neck, Laryngeal Diseases

NCT04892849 2025-09-17

ST-ICI02

GastrointestinalGenitourinaryHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Esophageal Neoplasms

NCT06771674 2025-09-09

Real-world Study of First Line Pembrolizumab- or Nivolumab-treated HPV-positive Recurrent/Metastatic Oropharyngeal Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT06686342 2025-09-03

PDO Based Drug Sensitive Test in R/M HNSCC

Squamous Cell Carcinoma of Head and Neck

NCT05059444 2025-08-22

ORACLE

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Esophageal Neoplasms, Fallopian Tube Neoplasms, Melanoma, Rectal Neoplasms, Ureteral Neoplasms, Endometrial Neoplasms

NCT07133958 2025-08-21

A Bidirectional Observational Clinical Study of NAIC in the Treatment of Tumor Regression Patterns in LA-OSCC and LA-OPSCC

Squamous Cell Carcinoma of Head and Neck

NCT07131566 2025-08-20

Immune Response in Cervical Lymph Nodes of Patients With Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07127614 2025-08-17

Primary Tumor Depth of Invasion and Lymph Node Management in Oral Squamous Cell Carcinoma

Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT06362421 2025-07-31

Saliva Testing for High-Risk Human Papillomavirus Infection Oral Cavity and Pharynx Cancer

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT06236464 2025-07-29

Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms

NCT04965792 2025-06-17

Post-treatment Surveillance in HPV+ Oropharyngeal SCC

Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT07015333 2025-06-11

Case Review of Patients With Betel Nut-induced Oral Cancer Treated With Pembrolizumab and Cetuximab

Squamous Cell Carcinoma of Head and Neck

NCT06055868 2025-05-28

People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity

Squamous Cell Carcinoma of Head and Neck, Coitus, HIV Infections, Papillomavirus Infections

NCT06757530 2025-05-28

Radiomics Model for Assessing Lymph Node Status in cN0 Patients withHNSCC

Squamous Cell Carcinoma of Head and Neck

NCT06321003 2025-05-23

SYMILIS OCT

DermatologicHead & Neck

Actinic cheilitis, Squamous Cell Carcinoma of Head and Neck, Graft vs Host Disease, Leukoplakia, Oral, Mouth Diseases, Mouth Neoplasms, Lichen Planus, Oral, Keratosis, Actinic

NCT03953443 2025-05-22

Expression & Epigenetic Silencing of MicroRNA for Predicting Therapeutic Response and Prognosis of HPV-negative HNSCC

Squamous Cell Carcinoma of Head and Neck