Announcements Trials
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Phase

Phase 3 2Phase 2 2

Status

Completed 4

Sponsor Class

INDUSTRY 3NETWORK 1

Study Type

Interventional 4

Sponsor

Cancer Type

Gynecologic 4Gastrointestinal 1

Conditions

Squamous Intraepithelial Lesions 4Uterine Cervical Neoplasms 3Uterine Cervical Dysplasia 2Vulvar High Grade Squamous Intraepithelial Lesion (HSIL) 1Papillomavirus Infections 1Head and Neck Squamous Cell Cancer 1HIV Seropositivity 1Anus Neoplasms 1

Interventions

VGX-3100 4Light Coagulation 3Watchful Waiting 2Polymerase Chain Reaction 2Imiquimod 2Fluorouracil 2Electroporation 2Cidofovir 24,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone 2Solutions 1Radiofrequency Ablation 1Observation 1Mindfulness-Based Stress Reduction 1Laser Therapy 1Immunohistochemistry 1Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 1Histological Techniques 1Gene Expression Profiling 1Folic Acid 1Electroporation Therapies 1Data Collection 1DNA Methylation 1Blue Light 1Biopsy 1Aminolevulinic Acid 15-aminolaevulinic acid-n-pentylester 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Completed × Squamous Intraepithelial Lesions × VGX-3100 × Clear all
NCT03603808 2026-05-08

VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

AIDS Malignancy Consortium

Phase 2 Completed
44 enrolled 15 charts
Gynecologic

Squamous Intraepithelial Lesions, HIV Seropositivity

NCT03721978 2024-10-17

REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)

Inovio Pharmaceuticals

Phase 3 Completed
203 enrolled 34 charts
Gynecologic

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT03185013 2023-07-27

REVEAL 1

Inovio Pharmaceuticals

Phase 3 Completed
201 enrolled 23 charts
Gynecologic

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT03499795 2023-07-14

VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 and/or HPV-18 Related Anal or Anal/Peri-Anal, High Grade Squamous Intraepithelial Lesion (HSIL) in Individuals Seronegative for Human Immunodeficiency Virus (HIV)-1/2

Inovio Pharmaceuticals

Phase 2 Completed
23 enrolled 19 charts
GastrointestinalGynecologic

Squamous Intraepithelial Lesions, Anus Neoplasms

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