Clinical Trials Browser

Interventional × Squamous Intraepithelial Lesions × Clear all

NCT07572396 2026-05-14

Phase II Study of Dysplasix™ Intravaginal Suppositories in Patients Patients With High-Risk HPV and Mild Cervical Cytologic Abnormalities

Phase 2 Recruiting

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia, Papillomavirus Infections, Atypical Squamous Cells of the Cervix

NCT03603808 2026-05-08

VGX-3100 and Electroporation in Treating Patients With HIV-Positive High-Grade Anal Lesions

Phase 2 Completed

44 enrolled 15 charts

Squamous Intraepithelial Lesions, HIV Seropositivity

NCT06233331 2026-05-08

Use of ACU-D1 in HPV Associated Vulvar and Perianal Lesions in People With HIV

Phase 1 Not yet recruiting

Squamous Intraepithelial Lesions, Acquired Immunodeficiency Syndrome

NCT06949800 2026-05-01

CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial

Phase 2 Not yet recruiting

Squamous Intraepithelial Lesions

NCT07029152 2026-05-01

SCOPE

Phase NA Recruiting

GastrointestinalGynecologic

Squamous Intraepithelial Lesions, Anus Neoplasms, Carcinoma, Squamous Cell, Homosexuality

NCT07480902 2026-03-18

Comparison Between Liquid-Based Cytology And Molecular Screening For Detecting Precursor Lesions and Cervical Cancer

Phase NA Recruiting

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Atypical Squamous Cells of the Cervix

NCT07306260 2025-12-29

PDT for CIN2

Phase NA Not yet recruiting

Squamous Intraepithelial Lesions, Papillomavirus Infections

NCT05381597 2025-11-28

5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer

Phase 2/3 Recruiting

Squamous Intraepithelial Lesions

NCT02059499 2025-07-23

Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions

Phase 3 Completed

91 enrolled 26 charts

Squamous Intraepithelial Lesions, HIV Infections

NCT06052033 2025-05-13

Comparison of 5-ALA Photodynamic Therapy and CO2 Laser for Treating Persistent Low-Grade Cervical Lesions With High-Risk HPV Infection

Phase NA Recruiting

Squamous Intraepithelial Lesions, Papillomavirus Infections

NCT06159842 2025-02-12

Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (isSCC)

Phase 2 Completed

DermatologicGynecologic

Squamous Intraepithelial Lesions, Carcinoma, Squamous Cell, Skin Neoplasms

NCT06525870 2024-11-14

Trichlosil

Phase 2 Enrolling by invitation

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT03721978 2024-10-17

REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)

Phase 3 Completed

203 enrolled 34 charts

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT06577311 2024-08-29

Evaluating the Use of Photodynamic Therapy to Treat Facial Cutaneous Squamous Cell Carcinoma in Situ (SCCis)

Phase 2 Recruiting

DermatologicGynecologic

Squamous Intraepithelial Lesions, Carcinoma, Squamous Cell, Skin Neoplasms

NCT06491888 2024-08-15

A Multicenter Randomized Controlled Study of Photoelectric Detection in Cervical Cancer Screening

Phase NA Not yet recruiting

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms

NCT02135419 2024-07-26

ANCHOR

Phase 3 Completed

4,446 enrolled 13 charts

GastrointestinalGynecologic

Squamous Intraepithelial Lesions, Acquired Immunodeficiency Syndrome, Anus Neoplasms, HIV Infections, Papillomavirus Infections

NCT06366516 2024-04-16

MTTRIHPW

Phase NA Unknown

10,000 enrolled

Squamous Intraepithelial Lesions, Adenocarcinoma in Situ

NCT05916911 2024-02-07

Evaluation Of The Efficacy Of The Combination Of GLIZIGEN® Oral Solution 1/Day And Vaginal Gel 1/Night For 2 Months In Patients With Cervical Intraepithelial Neoplasia Grade 1 (LSIL/CIN-1) Caused By High-Risk Human Papillomavirus (HPV-AR)

Phase 4 Unknown

Squamous Intraepithelial Lesions, Papillomavirus Infections

NCT02481414 2023-12-18

A Clinical Trial of PepCan to Two Therapy Arms for Treating Cervical High-Grade Squamous Intraepithelial Lesions

Phase 2 Completed

81 enrolled 19 charts

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT00513526 2023-11-14

Human Papillomavirus Vaccine Therapy in Treating Men With HIV-1 Infection

Phase 2 Completed

112 enrolled 16 charts

GynecologicOther neoplasm

Squamous Intraepithelial Lesions, Infections, Precancerous Conditions, Atypical Squamous Cells of the Cervix

NCT03185013 2023-07-27

REVEAL 1

Phase 3 Completed

201 enrolled 23 charts

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT03499795 2023-07-14

VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 and/or HPV-18 Related Anal or Anal/Peri-Anal, High Grade Squamous Intraepithelial Lesion (HSIL) in Individuals Seronegative for Human Immunodeficiency Virus (HIV)-1/2

Phase 2 Completed

23 enrolled 19 charts

GastrointestinalGynecologic

Squamous Intraepithelial Lesions, Anus Neoplasms

NCT00873288 2023-03-21

Activating Collaborative CIS Support Via Targeted Provider Mailing

Phase NA Completed

254 enrolled 8 charts

GynecologicOther neoplasm

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia, Precancerous Conditions, Atypical Squamous Cells of the Cervix

NCT05485259 2022-08-03

Effect of Alpha-lipoic Acid on Regression of Low-grade Squamous Intraepithelial Lesions (LSIL)

Phase NA Completed

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT02503111 2022-06-13

HPV-SAVE

Phase NA Terminated

GastrointestinalGynecologic

Squamous Intraepithelial Lesions, Acquired Immunodeficiency Syndrome, Anus Neoplasms, Carcinoma, Squamous Cell, Homosexuality

NCT05170620 2021-12-28

Research of Laser Ablation for the Treatment of Lower Anogenital Tracts' Precancerous Lesions

Phase NA Unknown

Squamous Intraepithelial Lesions, Bowen's Disease, Uterine Cervical Dysplasia

NCT03697226 2021-01-13

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection.

Phase 1 Completed

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms

NCT00503581 2020-11-03

Megestrol in Treating Patients With Endometrial Neoplasia or Endometrial Hyperplasia

Phase 2 Terminated

9 enrolled 5 charts

Squamous Intraepithelial Lesions

NCT01164722 2020-08-04

Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia

Phase 3 Completed

120 enrolled 13 charts

GastrointestinalGynecologicOther neoplasm

Squamous Intraepithelial Lesions, Anus Neoplasms, Precancerous Conditions, HIV Infections, Papillomavirus Infections

NCT01245972 2019-09-16

PDLNMSC

Phase NA Completed

23 enrolled 5 charts

DermatologicGynecologic

Squamous Intraepithelial Lesions, Carcinoma, Basal Cell, Carcinoma, Squamous Cell

NCT03677960 2019-07-24

Study of Topical ABI-1968 in Subjects With Precancerous Anal Lesions Resulting From Human Papillomavirus (HPV) Infection

Phase 1 Terminated

GastrointestinalGynecologic

Squamous Intraepithelial Lesions, Anus Neoplasms, HIV Infections, Papillomavirus Infections

NCT03239223 2019-07-10

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection

Phase 1 Completed

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms

NCT02631863 2019-07-08

Aminolaevulinic Acid Photodynamic Therapy for HPV+ Low Grade Cervical Intraepithelial Neoplasia (LSIL;CIN1)

Phase 2 Completed

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia, Papillomavirus Infections

NCT03202992 2019-02-07

Study of Topical ABI-1968 in Subjects With Precancerous Anal Lesions Resulting From Human Papillomavirus (HPV) Infection

Phase 1 Completed

GastrointestinalGynecologic

Squamous Intraepithelial Lesions, Anus Neoplasms, HIV Infections, Papillomavirus Infections

NCT02576561 2017-10-25

Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL

Phase 2 Unknown

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT03302858 2017-10-05

A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand

Phase 2 Unknown

GastrointestinalGynecologic

Squamous Intraepithelial Lesions, Anus Neoplasms, Papillomavirus Infections

NCT00653146 2016-12-05

The Effects of MBSR in Improving Immune Response to Human Papillomavirus in Patients With Cervical Dysplasia

Phase NA Completed

GynecologicOther neoplasm

Squamous Intraepithelial Lesions, Uterine Cervical Neoplasms, Precancerous Conditions, Papillomavirus Infections, Atypical Squamous Cells of the Cervix

NCT02976987 2016-11-30

A Prolongation of a Clinical Study to Evaluate the Efficacy of an Aqueous Gel Containing 2% (w/w) of Cidofovir, Directly Applied on the Cervix Exhibiting High Grade Squamous Intraepithelial Lesions.

Phase 2 Completed

Squamous Intraepithelial Lesions

NCT02189161 2016-07-14

A Safety and Tolerability of Circumferential Anal Canal Radiofrequency Ablation For Anal Intraepithelial Neoplasia

Phase NA Completed

10 enrolled 6 charts

Squamous Intraepithelial Lesions

NCT00550589 2015-12-21

Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus

Phase 2 Completed

33 enrolled 11 charts

GastrointestinalGynecologicOther neoplasm

Squamous Intraepithelial Lesions, Anus Neoplasms, Precancerous Conditions

NCT00703196 2015-10-08

Folic Acid Clinical Trial for the Prevention of Cervical Cancer

Phase 2 Completed

GynecologicOther neoplasm

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Precancerous Conditions, Papillomavirus Infections, Atypical Squamous Cells of the Cervix

NCT00066430 2014-09-17

Infrared Coagulation in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia

Phase 1 Completed

GastrointestinalGynecologicOther neoplasm

Squamous Intraepithelial Lesions, Anus Neoplasms, Precancerous Conditions

NCT00072540 2013-11-08

S0212 Celecoxib in Treating Patients With High-Grade Squamous Intraepithelial Lesions of the Cervix

Phase 2 Withdrawn

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT00091130 2013-06-03

SGN-00101 Vaccine in Treating Human Papillomavirus in Patients Who Have Abnormal Cervical Cells

Phase 2 Completed

Squamous Intraepithelial Lesions, Uterine Cervical Neoplasms, Atypical Squamous Cells of the Cervix

NCT00868088 2011-07-06

Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip

Phase 4 Completed

Actinic cheilitis, Squamous Intraepithelial Lesions, Carcinoma, Squamous Cell

NCT00285207 2010-10-11

Safety and Efficacy of A-007 Topical Gel in the Treatment of High-Grade Squamous Intraepithelial Lesions (HSIL) of the Cervix

Phase 2 Completed

147 enrolled 6 charts

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia

NCT00596258 2009-05-22

TG-003

Phase 2 Completed

Squamous Intraepithelial Lesions, Uterine Cervical Dysplasia