Clinical Trials

Phase 2 Active not recruiting

Colonic Neoplasms, Esophageal Neoplasms, Liver Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT02465060 2026-04-13

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

6,452 enrolled 2 FDA

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellThoracic

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Glioma, Carcinoma, Hepatocellular, Lung Neoplasms, Lymphoma, Melanoma, Multiple Myeloma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT04314401 2026-04-13

National Cancer Institute "Cancer Moonshot Biobank"

Active not recruiting

1,600 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicOther hematologic neoplasmPlasma cellThoracic

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Fallopian Tube Neoplasms, Lung Neoplasms, Melanoma, Multiple Myeloma, Ovarian Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT04550494 2026-04-13

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

Phase 2 Recruiting

36 enrolled

BreastGastrointestinalGenitourinaryGynecologic

Breast Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms

NCT04704661 2026-04-13

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

Phase 1 Recruiting

51 enrolled

BreastGastrointestinalGynecologicHead & NeckSarcoma

Breast Neoplasms, Carcinosarcoma, Colonic Neoplasms, Neoplasm Metastasis, Salivary Gland Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT06364410 2026-04-13

Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors

Phase 1 Recruiting

48 enrolled

BreastGastrointestinalGenitourinaryGynecologicThoracic

Neoplasm Metastasis, Stomach Neoplasms

NCT06995898 2026-04-13

The Vanguard Study: Testing a New Way to Screen for Cancer

Phase NA Recruiting

24,000 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT01950572 2026-04-09

Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma

Recruiting

1,000 enrolled

GastrointestinalGynecologicOther solid neoplasmThoracic

Biliary Tract Neoplasms, Lung Neoplasms, Mesothelioma, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma

NCT00342654 2026-04-08

Nutrition Intervention Trials in Linxian Follow-up Study

32,902 enrolled

Esophageal Neoplasms, Neoplasms, Stomach Neoplasms

NCT01915225 2026-04-08

Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

Recruiting

1,800 enrolled

Phase 2 Active not recruiting

Bile Duct Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma

NCT02782949 2026-04-02

Curcumin in Preventing Gastric Cancer in Patients With Chronic Atrophic Gastritis or Gastric Intestinal Metaplasia

50 enrolled 10 charts

Gastritis, Atrophic, Stomach Neoplasms

NCT03030404 2026-03-27

Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

733 enrolled

CNSEndocrineGastrointestinalGenitourinaryGynecologicOther solid neoplasmSarcomaThoracic

Polyposis, Gastric, Neoplastic Syndromes, Hereditary, Stomach Neoplasms

NCT06503146 2026-03-27

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

Phase 2 Recruiting

320 enrolled

Urinary Bladder Neoplasms, Carcinoma, Hepatocellular, Mesothelioma, Ovarian Neoplasms, Paraganglioma, Pheochromocytoma, Sarcoma, Stomach Neoplasms, Cholangiocarcinoma, Small Cell Lung Carcinoma

NCT03745326 2026-03-19

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

Phase 1/2 Completed

5 enrolled

GastrointestinalGynecologicOther solid neoplasmThoracic

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT06885697 2026-02-17

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

Phase 1 Recruiting

100 enrolled

Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma, Thymus Neoplasms

NCT03008278 2026-02-03

Olaparib and Ramucirumab in Treating Patients With Metastatic or Locally Recurrent Gastric or Gastroesophageal Junction Cancer That Cannot Be Removed by Surgery

Phase 1/2 Completed

51 enrolled 20 charts

Esophageal Neoplasms, Stomach Neoplasms

NCT03190941 2025-12-02

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

Phase 1/2 Recruiting

110 enrolled

Colonic Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT03027427 2025-02-28

Prospective Evaluation and Molecular Profiling in People With Gastric Tumors

109 enrolled

Stomach Neoplasms

NCT03092518 2025-02-19

Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer With Positive Peritoneal Cytology

27 enrolled 13 charts

Adenocarcinoma, Stomach Neoplasms

NCT04034251 2025-02-03

Intraperitoneal and Intravenous Paclitaxel Chemotherapy With Oral Capecitabine for Gastric Adenocarcinoma With Peritoneal Carcinomatosis

GastrointestinalGynecologic

12 enrolled 18 charts

Adenocarcinoma, Peritoneal Neoplasms, Stomach Neoplasms

NCT04535414 2025-01-17

Phase II Randomized Trial of Bethesda Protocol Compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers

195 enrolled 10 charts

Phase 1 Active not recruiting

Disease, Stomach Neoplasms

NCT04535401 2024-10-10

Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines

10 enrolled

Stomach Neoplasms, Colorectal Neoplasms

NCT00341523 2024-05-01

Early Detection of Esophageal Cancer

6,864 enrolled

Esophageal Neoplasms, Stomach Neoplasms

NCT01445327 2022-02-01

Predictors of Tumor Response and of Radiation Therapy Side Effects in Patients With Gastrointestinal Cancers

9 enrolled 8 charts

Esophageal Neoplasms, Gastrointestinal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms

NCT03648879 2021-07-12

Confocal Endoscopic Microscopy for Detection of Early Stage Gastric Cancer in Subjects With Hereditary Diffuse Gastric Cancer Syndrome

37 enrolled 8 charts

Disease, Stomach Neoplasms

NCT00064259 2021-02-17

A Phase I/II Study of Oblimersen Plus Cisplatin and Fluorouracil in Gastric & Esophageal Junction Cancer

Phase 1/2 Terminated

15 enrolled 5 charts

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms, Stomach Neoplasms

NCT00061932 2021-02-02

Bortezomib With or Without Irinotecan in Treating Patients With Cancer of the Gastroesophageal Junction or Stomach

41 enrolled 8 charts

Stomach Neoplasms

NCT02788214 2020-12-19

Helicobacter Pylori Genome Project (HpGP)

1,000 enrolled

Stomach Neoplasms

NCT03188406 2020-12-19

Gastric Cancer Precursor Lesions (GCPL) Study

1,300 enrolled

Gastritis, Atrophic, Stomach Neoplasms

NCT00342004 2020-08-04

A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women

BreastCNSGastrointestinalLymphoidThoracic

75,366 enrolled

Brain Neoplasms, Breast Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Stomach Neoplasms

NCT03076567 2020-02-25

Discovery and Validation of Plasma DNA Methylation Biomarker for Detection of Stomach Cancer

440 enrolled

Neoplasms, Stomach Neoplasms

NCT00923052 2019-12-16

The Natural History of Solid Organ Cancer Stem Cells (SOCSC)

190 enrolled

BreastGastrointestinal

Breast Neoplasms, Liver Neoplasms, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT00941655 2019-11-13

Prospective Randomized Trial Comparing Gastrectomy, Metastasectomy Plus Systemic Therapy Versus Systemic Therapy Alone: GYMSSA Trial

Phase 3 Completed

15 enrolled 18 charts

Carcinoma, Hepatocellular, Stomach Neoplasms

NCT00904514 2018-10-05

Study of Previously Collected and Stored Tissue Samples From Patients Previously Enrolled in a Completed National Cancer Institute Clinical Trial

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmOther solid neoplasmThoracic

241 enrolled

Congenital Abnormalities, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Urinary Bladder Neoplasms, Breast Neoplasms, Brenner Tumor, Burkitt Lymphoma, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Hodgkin Disease, Leukemia, Hairy Cell, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Neoplasms, Pancreatic Neoplasms, Salivary Gland Neoplasms, Sezary Syndrome, Stomach Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Prolymphocytic, Leukemia, Myeloid, Acute, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT00607594 2018-08-23

Saracatinib in Treating Patients With Locally Advanced or Metastatic Stomach or Gastroesophageal Junction Cancer

21 enrolled 11 charts

BreastGastrointestinalGynecologic

Esophageal Neoplasms, Stomach Neoplasms

NCT01437007 2018-08-03

TKM 080301 for Primary or Secondary Liver Cancer

Phase 1 Completed

1 enrolled

Adenocarcinoma, Breast Neoplasms, Disease, Liver Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT00068380 2018-07-11

A Phase II Trial of STI571 in the Treatment of Metastatic Gastric Cancer

17 enrolled 8 charts

Stomach Neoplasms

NCT00062374 2017-07-06

Irinotecan and Cisplatin in Treating Patients Who Are Undergoing Surgery For Locally Advanced Cancer of the Stomach or Gastroesophageal Junction

55 enrolled 7 charts

BreastGastrointestinalGynecologicHead & NeckOther solid neoplasmThoracic

Stomach Neoplasms

NCT02567396 2017-04-24

Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

Phase 1 Withdrawn

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Mesothelioma, Ovarian Neoplasms, Stomach Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT01216813 2016-11-01

Study of Physical and Psychosocial Rehabilitation Needs of Patients After Diagnosis and Treatment of Upper Gastrointestinal Cancer or Gynecological Cancer

GastrointestinalGynecologicSarcoma

33 enrolled

Carcinoma, Ovarian Epithelial, Uterine Cervical Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT00982592 2016-01-25

Combination Chemotherapy With or Without Vismodegib in Treating Patients With Advanced Stomach Cancer or Gastroesophageal Junction Cancer

124 enrolled 12 charts

Stomach Neoplasms

NCT01260701 2016-01-18

Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer

75 enrolled 9 charts

CNSGastrointestinalHead & NeckSarcomaThoracic

Stomach Neoplasms

NCT00397384 2015-09-30

Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer

Phase 1 Completed

43 enrolled

Squamous Cell Carcinoma of Head and Neck, Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Pancreatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Stomach Neoplasms, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory, Gastrointestinal Stromal Tumors

NCT00084617 2015-05-01

Phase II Study of Oxaliplatin, Irinotecan, and Capecitabine in Advanced Gastric/Gastroesophageal Junction Carcinoma

39 enrolled 7 charts