Clinical Trials

Phase 2 Not yet recruiting

Thyroid Cancer, Papillary, Thyroid Neoplasms, Carcinoma, Medullary, Thyroid Carcinoma, Anaplastic

NCT07470489 2026-04-16

Zanzalintinib Plus Cemiplimab for the Treatment of BRAF Wild-Type Anaplastic Thyroid Cancer

12 enrolled

Phase 1 Not yet recruiting

Thyroid Carcinoma, Anaplastic

NCT07485569 2026-04-15

REPOTHYROID-II

10 enrolled

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT05696548 2026-04-09

Nivolumab Plus Lenvatinib Against Anaplastic Thyroid Cancer (NAVIGATION)

51 enrolled

Thyroid Carcinoma, Anaplastic

NCT03975231 2026-04-08

Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer

Phase 1 Recruiting

6 enrolled

Phase 2/3 Not yet recruiting

Thyroid Carcinoma, Anaplastic

NCT07440290 2026-02-27

DETERMINE

CNSEndocrineGastrointestinalGynecologicHead & NeckLymphoidMyeloidOther hematologic neoplasmPlasma cellThoracic

Thyroid Cancer, Papillary, Carcinoma, Non-Small-Cell Lung, Gastrointestinal Neoplasms, Glioma, Histiocytosis, Langerhans-Cell, Laryngeal Neoplasms, Lymphoproliferative Disorders, Multiple Myeloma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Ovarian Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms, Erdheim-Chester Disease, Thyroid Carcinoma, Anaplastic

NCT04675710 2026-02-19

Pembrolizumab, Dabrafenib, and Trametinib Before Surgery for the Treatment of BRAF-Mutated Anaplastic Thyroid Cancer

Thyroid Carcinoma, Anaplastic

NCT04171622 2026-02-17

Lenvatinib and Pembrolizumab for the Treatment of Stage IVB Locally Advanced and Unresectable or Stage IVC Metastatic Anaplastic Thyroid Cancer

25 enrolled

Phase EARLY_PHASE1 Recruiting

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT06639191 2026-01-30

AKIR001

15 enrolled

EndocrineGynecologicHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Vulvar Neoplasms, Thyroid Carcinoma, Anaplastic

NCT03181100 2026-01-09

Atezolizumab With Chemotherapy in Treating Patients With Anaplastic or Poorly Differentiated Thyroid Cancer

50 enrolled

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT05768178 2025-11-24

DETERMINE

Phase 2/3 Recruiting

CNSDermatologicEndocrineGastrointestinalGynecologicHead & NeckMyeloidOther hematologic neoplasmPlasma cellThoracic

Thyroid Cancer, Papillary, Carcinoma, Non-Small-Cell Lung, Glioma, Laryngeal Neoplasms, Melanoma, Multiple Myeloma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Ovarian Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms, Erdheim-Chester Disease, Thyroid Carcinoma, Anaplastic

NCT06902376 2025-11-05

NEO-COMBATXL

Phase 1 Recruiting

12 enrolled

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT05453799 2025-10-20

Vudalimab for the Treatment of Locally Advanced or Metastatic Anaplastic Thyroid Cancer or Hurthle Cell Thyroid Cancer

54 enrolled

Thyroid Carcinoma, Anaplastic

NCT06790706 2025-10-06

IMMUNORARE5

EndocrineGastrointestinalGynecologicHead & NeckNETThoracic

154 enrolled

Gastro-enteropancreatic neuroendocrine tumor, Carcinoid Tumor, Thymoma, Gestational Trophoblastic Disease, Thyroid Carcinoma, Anaplastic

NCT06374602 2025-09-05

Efficacy of Pembrolizumab and Lenvatinib in Patients With Anaplastic Thyroid Cancer

20 enrolled

Phase EARLY_PHASE1 Active not recruiting

Thyroid Carcinoma, Anaplastic

NCT03085056 2025-07-03

Trametinib in Combination With Paclitaxel in the Treatment of Anaplastic Thyroid Cancer

13 enrolled

Thyroid Carcinoma, Anaplastic

NCT04238624 2025-07-02

Study of Cemiplimab Combined With Dabrafenib and Trametinib in People With Anaplastic Thyroid Cancer

16 enrolled

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT04400474 2025-06-19

CABATEN

CNSEndocrineHead & NeckNET

93 enrolled 17 charts

Adenocarcinoma, Paraganglioma, Pheochromocytoma, Neuroendocrine Tumors, Thyroid Carcinoma, Anaplastic

NCT04552769 2025-06-05

Abemaciclib in Metastatic or Locally Advanced Anaplastic/Undifferentiated Thyroid Cancer

9 enrolled 10 charts

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT02152137 2025-01-27

Inolitazone Dihydrochloride and Paclitaxel in Treating Patients With Advanced Anaplastic Thyroid Cancer

19 enrolled 13 charts

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT06235216 2024-11-01

SETHY

42 enrolled

Thyroid Carcinoma, Anaplastic

NCT03565536 2024-04-19

Nexavar for Neoadjuvant Treatment of Anaplastic Thyroid Cancer

18 enrolled

Thyroid Carcinoma, Anaplastic

NCT06362694 2024-04-12

Study of the Rechallenge Concept in Patients With BRAF-positive Anaplastic Thyroid Cancer After Progression on Anti-BRAF Therapy

10 enrolled

Thyroid Carcinoma, Anaplastic

NCT04739566 2024-03-25

ANAPLAST-NEO

Phase 2 Withdrawn

Thyroid Carcinoma, Anaplastic

NCT02244463 2024-01-12

A Phase I/II Study of MLN0128 in Metastatic Anaplastic Thyroid Cancer and Incurably Poorly Differentiated or Radioidodine Refractory Differentiated Thyroid Cancer

Phase 1/2 Completed

46 enrolled 18 charts

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT06079333 2023-10-12

NEO-ATACT

20 enrolled

Thyroid Carcinoma, Anaplastic

NCT03122496 2022-06-08

Immunotherapy and Stereotactic Body Radiotherapy (SBRT) for Metastatic Anaplastic Thyroid Cancer

Phase 1 Completed

13 enrolled

Thyroid Carcinoma, Anaplastic

NCT02688608 2022-02-10

Pembrolizumab in Anaplastic/Undifferentiated Thyroid Cancer

6 enrolled 10 charts

Thyroid Carcinoma, Anaplastic

NCT02726503 2020-06-17

HOPE

39 enrolled

Thyroid Carcinoma, Anaplastic

NCT03211117 2020-03-25

Pembrolizumab, Chemotherapy, and Radiation Therapy With or Without Surgery in Treating Patients With Anaplastic Thyroid Cancer

3 enrolled 7 charts

Thyroid Carcinoma, Anaplastic

NCT00654238 2019-11-18

Phase II Trial of Sorafenib (Nexavar) in Patients With Advanced Thyroid Cancer

59 enrolled 8 charts

Thyroid Neoplasms, Carcinoma, Medullary, Thyroid Carcinoma, Anaplastic

NCT02289144 2019-07-30

Ceritinib in Mutation and Oncogene Directed Therapy in Thyroid Cancer

Phase 2 Withdrawn

Thyroid Carcinoma, Anaplastic

NCT00804830 2018-08-28

Avastin and Doxorubicin Postoperatively for Patients With Anaplastic Thyroid Cancer

Phase 2 Terminated

15 enrolled

Carcinoma, Neoplasm Metastasis, Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT00416949 2018-07-18

Iodine I 131 in Treating Patients With Thyroid Cancer

Phase NA Terminated

9 enrolled 4 charts

Thyroid Cancer, Papillary, Head and Neck Neoplasms, Thyroid Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary, Thyroid Carcinoma, Anaplastic

NCT00095836 2017-05-31

Gefitinib in Treating Patients With Locally Advanced or Metastatic Thyroid Cancer That Did Not Respond to Iodine Therapy

27 enrolled 16 charts

Thyroid Cancer, Papillary, Head and Neck Neoplasms, Thyroid Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary, Thyroid Carcinoma, Anaplastic

NCT02516774 2016-01-26

TAM-RT

Phase 1 Withdrawn

Thyroid Carcinoma, Anaplastic

NCT01164176 2014-12-02

Everolimus in Treating Patients With Locally Advanced or Metastatic Thyroid Cancer

40 enrolled

Thyroid Cancer, Papillary, Head and Neck Neoplasms, Thyroid Neoplasms, Adenocarcinoma, Follicular, Carcinoma, Medullary, Thyroid Carcinoma, Anaplastic

NCT00115739 2014-04-21

Trial Evaluating Gleevec in Patients With Anaplastic Thyroid Carcinoma

Phase 2 Terminated

11 enrolled 10 charts

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT00786552 2011-01-20

Panthera

Phase 2 Unknown

47 enrolled

Recurrence, Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT00060242 2010-06-11

Combretastatin A4 Phosphate in Treating Patients With Advanced Anaplastic Thyroid Cancer

26 enrolled

Head and Neck Neoplasms, Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT00077103 2010-06-11

Induction Chemotherapy Using Doxorubicin and Cisplatin Followed by Combretastatin A4 Phosphate and Radiation Therapy in Treating Patients With Newly Diagnosed Regionally Advanced Anaplastic Thyroid Cancer

Phase 1/2 Terminated

4 enrolled