Clinical Trials

Phase 3 Active not recruiting

Neoplasm Metastasis, Thyroid Neoplasms, Carcinoma, Medullary

NCT03690388 2025-09-25

A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

187 enrolled 13 charts 2 FDA

Thyroid cancer, follicular, Thyroid Cancer, Papillary, Thyroid Neoplasms, Adenocarcinoma, Follicular

NCT00410761 2025-09-24

An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer

331 enrolled 15 charts

Phase 4 Active not recruiting

Familial medullary thyroid carcinoma, Thyroid Neoplasms, Carcinoma, Medullary

NCT01896479 2025-09-02

EXAMINER

247 enrolled 14 charts

590 enrolled 58 charts 8 FDA

Thyroid Neoplasms, Carcinoma, Medullary

NCT03037385 2025-05-31

ARROW

Phase 1/2 Completed

EndocrineGastrointestinalHead & NeckNETThoracic

Thyroid Cancer, Papillary, Adenocarcinoma, Adenocarcinoma, Papillary, Bronchial Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Colorectal Neoplasms, Neuroectodermal Tumors, Carcinoma, Medullary, Carcinoma, Neuroendocrine, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 2a

NCT04420689 2025-05-08

Bevonescein to Highlight Nerves in Patients Undergoing Head & Neck Surgery

Phase 1/2 Completed

27 enrolled 14 charts

Phase 2 Active not recruiting

Head and Neck Neoplasms, Parotid Neoplasms, Thyroid Neoplasms

NCT04280081 2025-04-20

LIBRETTO-321

77 enrolled 13 charts

Head & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Thyroid Neoplasms, Carcinoma, Medullary

NCT03127098 2024-08-06

QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803 (Super-agonist IL-15) in Subjects Having CEA-Expressing Cancer

Phase 1/2 Terminated

3 enrolled 6 charts

BreastGastrointestinalGynecologicHead & NeckThoracic

Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms, Thyroid Neoplasms

NCT02383927 2024-07-11

Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutations

63 enrolled 19 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Thyroid Neoplasms

NCT04161391 2024-06-13

Study of TPX-0046, A RET/SRC Inhibitor in Adult Subjects With Advanced Solid Tumors Harboring RET Fusions or Mutations

Phase 1/2 Terminated

41 enrolled 18 charts

Head & NeckThoracic

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis, Thyroid Neoplasms, Carcinoma, Medullary

NCT00537095 2024-04-19

Efficacy and Safety of Vandetanib (ZD6474) in Patients With Metastatic Papillary or Follicular Thyroid Cancer

164 enrolled 10 charts

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidNETSarcomaThoracic

Thyroid Neoplasms

NCT04644315 2023-08-07

ALpha-T

Phase 2 Terminated

1 enrolled 5 charts

Thyroid Cancer, Papillary, Brain Neoplasms, Breast Neoplasms, Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Renal Cell, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Melanoma, Neoplasms, Neoplasms by Site, Ovarian Neoplasms, Pancreatic Neoplasms, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Salivary Gland Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Lymphoma, Large-Cell, Anaplastic, Cholangiocarcinoma, Neuroendocrine Tumors

NCT02988817 2023-08-01

Enapotamab Vedotin (HuMax-AXL-ADC) Safety Study in Patients With Solid Tumors

Phase 1/2 Completed

306 enrolled 51 charts

DermatologicGynecologicHead & NeckSarcomaThoracic

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Melanoma, Ovarian Neoplasms, Sarcoma, Thyroid Neoplasms, Endometrial Neoplasms

NCT01321554 2023-06-22

SELECT

392 enrolled 10 charts

Thyroid Neoplasms

NCT02702388 2021-11-24

A Trial of Lenvatinib (E7080) in Subjects With Iodine-131 Refractory Differentiated Thyroid Cancer to Evaluate Whether an Oral Starting Dose of 18 Milligram (mg) Daily Will Provide Comparable Efficacy to a 24 mg Starting Dose, But Have a Better Safety Profile

241 enrolled 32 charts

Thyroid Neoplasms

NCT00704730 2021-04-20

EXAM

330 enrolled 14 charts

Thyroid Neoplasms, Carcinoma, Medullary

NCT01728623 2020-08-14

A Study of E7080 in Subjects With Advanced Thyroid Cancer

51 enrolled 15 charts

Thyroid Neoplasms

NCT00784303 2020-04-22

Evaluating the Safety and Efficacy of Oral Lenvatinib in Medullary and Iodine-131 Refractory, Unresectable Differentiated Thyroid Cancers, Stratified by Histology

117 enrolled 19 charts

BreastGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

Thyroid Neoplasms

NCT00428220 2019-06-27

A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.

Phase NA Completed

223 enrolled 8 charts

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Adenoma, Islet Cell, Somatostatinoma, Thyroid Neoplasms, Gastrointestinal Stromal Tumors

NCT00896454 2018-10-17

Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium

BreastGastrointestinalGenitourinaryHead & NeckLymphoidPlasma cellThoracic

33 enrolled 22 charts

Humoral Hypercalcemia Of Malignancy, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Endocrine Gland Neoplasms, Head and Neck Neoplasms, Hodgkin Disease, Hypercalcemia, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Lymphoma, Non-Hodgkin, Multiple Myeloma, Neoplasm Metastasis, Neoplasms, Parathyroid Neoplasms, Thyroid Neoplasms

NCT00984282 2018-09-13

Nexavar® Versus Placebo in Locally Advanced/Metastatic RAI-Refractory Differentiated Thyroid Cancer

417 enrolled 22 charts

Thyroid Neoplasms

NCT00098345 2018-05-07

Efficacy and Tolerability of ZD6474 in Patients With Thyroid Cancer

40 enrolled 12 charts

Thyroid Neoplasms

NCT01831726 2017-03-20

SIGNATURE

DermatologicGastrointestinalGynecologicHead & NeckOther hematologic neoplasmSarcomaThoracic

80 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Ovarian Neoplasms, Thyroid Neoplasms, Leukemia, Myeloid, Acute, Hematologic Neoplasms, Gastrointestinal Stromal Tumors

NCT00358956 2017-01-30

A Study To Assess ZD6474 (ZACTIMA™) Monotherapy In Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer

19 enrolled 10 charts

Familial medullary thyroid carcinoma, Thyroid Neoplasms, Carcinoma, Medullary

NCT00507429 2014-06-09

FACT

Phase 2/3 Terminated

80 enrolled 10 charts

Thyroid Neoplasms, Thyroid Carcinoma, Anaplastic

NCT00389441 2013-11-25

Study Of AG-013736 In Patients With 131I-Refractory Thyroid Cancer

52 enrolled 9 charts

Carcinoma, Thyroid Neoplasms

NCT00094055 2012-06-26

Study of the Anti-angiogenesis Agent AG-013736 in Patients With Metastatic Thyroid Cancer

60 enrolled 9 charts