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Phase

Phase 1 1

Status

Recruiting 1

Sponsor Class

NIH 1

Study Type

Interventional 1

Sponsor

Cancer Type

Breast 1

Conditions

Leukemia, Myeloid, Acute 14Myelodysplastic Syndromes 7Myeloproliferative Disorders 3Myelodysplastic-Myeloproliferative Diseases 2Leukemia, Myelomonocytic, Chronic 2Triple Negative Breast Neoplasms 1Thrombocythemia, Essential 1Primary Myelofibrosis 1Polycythemia Vera 1Lymphoma, Large B-Cell, Diffuse 1Lymphoma, B-Cell 1Leukemia, Biphenotypic, Acute 1Hodgkin Disease 1GATA2 Deficiency 1Carcinoma, Non-Small-Cell Lung 1Carcinoma, Merkel Cell 1BRCA1 Mutation 1Anemia, Refractory, with Excess of Blasts 1Allogeneic Stem Cell Transplantation 1

Interventions

pembrolizumab 23Carboplatin 23Paclitaxel 17Specimen Handling 15Magnetic Resonance Spectroscopy 11Cyclophosphamide 10Biopsy 10Taxes 7Capecitabine 7Nivolumab 6130-nm albumin-bound paclitaxel 6sacituzumab govitecan 5Gemcitabine 5Doxorubicin 5Albumin-Bound Paclitaxel 5Fulvestrant 4olaparib 3fludarabine 3eribulin 3durvalumab 3atezolizumab 3Letrozole 3Epirubicin 3Bevacizumab 3veliparib 2poly ICLC 2pertuzumab 2aldesleukin 2abemaciclib 2Trastuzumab 2

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Triple Negative Breast Neoplasms × decitabine and cedazuridine drug combination × 30 days × Clear all
NCT05673200 2026-05-13

Testing the Addition of an Anti-cancer Drug, ASTX727 (Cedazuridine, Decitabine), to Chemotherapy (Paclitaxel) and Immunotherapy (Pembrolizumab) for Metastatic Triple-Negative Breast Cancer

National Cancer Institute (NCI)

Phase 1 Recruiting
32 enrolled
Breast

Triple Negative Breast Neoplasms

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