Clinical Trials

Uveal Melanoma, Melanoma, Neoplasm Metastasis

NCT06007690 2026-03-02

CoMpass

Phase 3 Recruiting

100 enrolled

Phase 1 Active not recruiting

Uveal Melanoma, Eye Neoplasms

NCT04336241 2026-02-27

Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors

36 enrolled

BreastDermatologicGastrointestinalThoracic

Uveal Melanoma, Breast Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Neoplasms

NCT07015190 2026-02-18

Neoadjuvant Darovasertib in Primary Uveal Melanoma

Phase 3 Recruiting

520 enrolled

Phase 2/3 Active not recruiting

Uveal Melanoma, Melanoma

NCT05987332 2026-02-17

IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma

420 enrolled

Uveal Melanoma, Melanoma

NCT03947385 2026-01-27

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

DermatologicGastrointestinal

336 enrolled

Uveal Melanoma, Melanoma, Colorectal Neoplasms

NCT06717126 2026-01-16

OCULE-01

Phase 2 Active not recruiting

85 enrolled

Uveal Melanoma, Melanoma

NCT03746431 2026-01-07

A Phase 1 Study of [225Ac]-FPI-1434 Injection

BreastDermatologicEndocrineGynecologicHead & Neck

78 enrolled

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms, Adrenocortical Carcinoma, Triple Negative Breast Neoplasms

NCT06022029 2025-12-24

ON-5001

Phase 1 Recruiting

168 enrolled

BreastDermatologicGenitourinaryGynecologicHead & NeckLymphoid

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Bites and Stings, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma in Situ, Uterine Cervical Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Neoplasm Metastasis, Neoplasms, Recurrence, Skin Neoplasms, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Triple Negative Breast Neoplasms

NCT05047536 2025-12-19

KZR-261 in Subjects With Advanced Solid Malignancies

DermatologicGastrointestinalOther solid neoplasmThoracic

61 enrolled 25 charts

Uveal Melanoma, Melanoma, Mesothelioma, Neoplasm Metastasis, Colorectal Neoplasms

NCT04130516 2025-12-18

Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab

DermatologicGastrointestinalThoracic

200 enrolled

Uveal Melanoma, Carcinoma, Non-Small-Cell Lung, Melanoma, Stomach Neoplasms

NCT06940739 2025-12-03

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

42 enrolled

Uveal Melanoma, Melanoma

NCT07136181 2025-11-28

NBM-BMX-UM

36 enrolled

Phase 1/2 Active not recruiting

Uveal Melanoma, Eye Neoplasms, Neoplasm Metastasis, Recurrence

NCT06784648 2025-11-19

Different Doses of BI-1607 in Combination With Pembrolizumab and Ipilimumab, in Participants With Unresectable or Metastatic Melanoma

35 enrolled

Uveal Melanoma, Melanoma, Neoplasm Metastasis

NCT04935229 2025-10-22

Intrahepatic Delivery of SD-101 by Pressure-Enabled Regional Immuno-oncology (PERIO), With Checkpoint Blockade in Adults With Metastatic Uveal Melanoma

67 enrolled

DermatologicEndocrineGastrointestinalGenitourinaryNETSarcomaThoracic

Uveal Melanoma

NCT06805825 2025-09-23

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

Phase 1 Recruiting

67 enrolled

Uveal Melanoma, Carcinoma, Renal Cell, Carcinoma, Adenoid Cystic, Piebaldism, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors, Small Cell Lung Carcinoma

NCT03611868 2025-08-07

A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Phase 1/2 Active not recruiting

230 enrolled

DermatologicSarcoma

Uveal Melanoma, Melanoma, Neurofibrosarcoma

NCT05415072 2025-07-20

A Phase I/II Study of DYP688 in Patients With Metastatic Uveal Melanoma and Other GNAQ/11 Mutant Melanomas

Phase 1/2 Active not recruiting

66 enrolled

Uveal Melanoma, Eye Neoplasms, Melanoma, Neoplasms

NCT04993677 2025-05-11

A Study of SEA-CD40 Given With Other Drugs in Cancers

Phase 2 Completed

77 enrolled 18 charts

DermatologicThoracic

Uveal Melanoma, Carcinoma, Non-Small-Cell Lung, Melanoma

NCT05576077 2025-03-10

STARLING

BreastDermatologicGastrointestinalHead & NeckThoracic

31 enrolled

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Colorectal Neoplasms

NCT04417530 2025-03-03

Phase 2 Trial to Evaluate Belzupacap Sarotalocan (AU-011) Via Suprachoroidal Administration in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma

Phase 2 Completed

22 enrolled

Uveal Melanoma, Eye Neoplasms

NCT04879017 2024-04-25

FHD-286 in Subjects With Metastatic Uveal Melanoma

76 enrolled

Uveal Melanoma

NCT03052127 2024-02-01

Study in Subjects With Small Primary Choroidal Melanoma

Phase 1/2 Completed

57 enrolled 26 charts

Uveal Melanoma, Eye Neoplasms

NCT02678572 2023-12-21

FOCUS

Phase 3 Completed

102 enrolled 2 FDA

Uveal Melanoma

NCT05022901 2023-12-21

An Open-Label Expanded Access Study of the Melphalan/Hepatic Delivery System (HDS) in Patients With Hepatic Dominant Ocular Melanoma

Phase 3 Unknown

30 enrolled

Uveal Melanoma

NCT04904120 2023-11-07

TIMAR1

7 enrolled

DermatologicMyeloidOther hematologic neoplasm

Uveal Melanoma, Disease, Melanoma, Neoplasm Metastasis, Neoplasms

NCT02743611 2023-10-05

Safety & Activity of Controllable PRAME-TCR Therapy in Previously Treated AML/MDS or Metastatic Uveal Melanoma

Phase 1/2 Terminated

4 enrolled 9 charts

Uveal Melanoma, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT03408587 2023-05-06

CLEVER

11 enrolled

Diabetes Mellitus, Insulin-Dependent, 12, Uveal Melanoma, Coxsackievirus Infections, Virus Diseases

NCT02570308 2023-03-21

A Study of the Intra-Patient Escalation Dosing Regimen With IMCgp100 in Patients With Advanced Uveal Melanoma

Phase 1/2 Completed

146 enrolled 26 charts

BreastDermatologicEndocrineGastrointestinalThoracic

Uveal Melanoma, Melanoma

NCT00986661 2022-11-02

A Study to Assess PV-10 Chemoablation of Cancer of the Liver

Phase 1 Unknown

78 enrolled

Uveal Melanoma, Breast Neoplasms, Carcinoid Tumor, Colonic Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Pancreatic Neoplasms, Colorectal Neoplasms

NCT04551352 2022-10-03

A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas

20 enrolled

Uveal Melanoma, Melanoma

NCT02601378 2022-09-29

A Phase I Study of LXS196 in Patients With Metastatic Uveal Melanoma.

107 enrolled

Uveal Melanoma

NCT03297424 2022-07-25

A Study of PLX2853 in Advanced Malignancies.

DermatologicLymphoidThoracic

49 enrolled

Uveal Melanoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Lymphoma, Large B-Cell, Diffuse, Small Cell Lung Carcinoma

NCT02315066 2022-04-21

Study Of OX40 Agonist PF-04518600 Alone And In Combination With 4-1BB Agonist PF-05082566

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

174 enrolled 68 charts

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms

NCT00084656 2022-04-14

Monoclonal Antibody Therapy and Vaccine Therapy in Treating Patients With Resected Stage III or Stage IV Melanoma

Phase 2 Completed

77 enrolled 13 charts

Uveal Melanoma, Melanoma

NCT03652077 2021-11-15

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmThoracic

40 enrolled

Turcot syndrome, Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Ovarian Neoplasms, Stomach Neoplasms, Carcinoma, Merkel Cell, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT00324727 2021-06-21

Hepatic Arterial Infusion With Melphalan Compared With Standard Therapy in Treating Patients With Unresectable Liver Metastases Due to Melanoma

Phase 3 Completed

93 enrolled

Uveal Melanoma, Melanoma, Neoplasm Metastasis

NCT01430416 2020-12-19

Safety and Efficacy of AEB071 in Metastatic Uveal Melanoma Patients

153 enrolled

Uveal Melanoma, Neoplasm Metastasis

NCT02771340 2020-10-01

Study Evaluating Single and Repeated Intravitreal Doses of ICON-1 in Patients With Uveal Melanoma

10 enrolled 10 charts

Uveal Melanoma, Choroid Neoplasms

NCT02029690 2020-09-25

TRAP

CNSDermatologicGastrointestinal

85 enrolled

Uveal Melanoma, Carcinoma, Glioma, Carcinoma, Hepatocellular

NCT01801358 2020-09-16

A Phase Ib/II Study of AEB071 and MEK162 in Adult Patients With Metastatic Uveal Melanoma

Phase 1/2 Terminated

38 enrolled 31 charts

Uveal Melanoma, Melanoma

NCT02889861 2020-07-27

IMCgp100-401 Rollover Study

Phase 2 Terminated

3 enrolled 14 charts