Clinical Trials

Uterine Cervical Neoplasms, Vaginal Neoplasms

NCT06638931 2026-04-15

ANTARES

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther solid neoplasmSarcomaThoracic

28 enrolled

Urachal adenocarcinoma, Urachal cancer, Fibrolamellar hepatocellular carcinoma, Secretory breast carcinoma, Carcinoma, Ovarian Epithelial, Adrenal Gland Neoplasms, Anus Neoplasms, Biliary Tract Neoplasms, Carcinosarcoma, Carcinoma, Adenoid Cystic, Fallopian Tube Neoplasms, Fibrosarcoma, Gallbladder Neoplasms, Granulosa Cell Tumor, Hemangiosarcoma, Leiomyosarcoma, Mesothelioma, Neuroblastoma, Parathyroid Neoplasms, Penile Neoplasms, Sarcoma, Sarcoma, Kaposi, Osteosarcoma, Thyroid Neoplasms, Trophoblastic Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Hepatoblastoma, Endodermal Sinus Tumor, Neuroectodermal Tumors, Primitive, Cholangiocarcinoma, Sertoli-Leydig Cell Tumor, Neurofibrosarcoma, Hemangioblastoma, Neuroendocrine Tumors

NCT07523152 2026-04-13

SAPPHIRE

Phase NA Not yet recruiting

42 enrolled

Anal Canal Carcinoma, Anus Neoplasms, Pelvic Neoplasms, Uterine Neoplasms, Vaginal Neoplasms

NCT05979610 2026-03-23

Reiki-Brachy

68 enrolled

Uterine Cervical Neoplasms, Genital Neoplasms, Female, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT03968406 2026-03-11

Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers

Phase 1 Recruiting

24 enrolled

GastrointestinalGenitourinaryGynecologicHead & Neck

Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Ovarian Neoplasms, Vaginal Neoplasms, Endometrial Neoplasms

NCT05639972 2026-02-27

E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers

Phase 1/2 Recruiting

15 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT05686226 2026-02-27

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

GastrointestinalGenitourinaryGynecologicHead & Neck

20 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Neoplasm Metastasis, Oropharyngeal Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT07424664 2026-02-20

A Single-arm, Multicenter Clinical Study of Becotatug Vedotin Combined With Zimberelimab in the Treatment of Recurrent and Metastatic Cervical Cancer, Vulvar Cancer and Vaginal Cancer

Phase 2 Not yet recruiting

30 enrolled

Uterine Cervical Neoplasms, Neoplasm Metastasis, Recurrence, Vaginal Neoplasms, Vulvar Neoplasms

NCT07407647 2026-02-12

Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer

25 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Rectal Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT06432478 2026-02-06

3D Printed Custom Applicators for HDR BT (DISCO)

10 enrolled

Phase NA Active not recruiting

Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT07226102 2026-02-04

Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer

Phase NA Withdrawn

BreastGynecologic

Genital Neoplasms, Female, Ovarian Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT05786456 2026-01-28

e-Health Intervention (Day-by-Day) for the Management of Fear of Progression in Women With Stage III or IV Gynecologic Cancer: A Pilot Study

23 enrolled

Uterine Cervical Neoplasms, Ovarian Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT02993900 2025-12-18

Image-Guided Gynecologic Brachytherapy

54 enrolled

GenitourinaryGynecologic

Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT06677190 2025-11-05

Belzutifan in Recurrent Clear Cell Carcinoma of Gynecologic Origin

32 enrolled

Uterine Cervical Neoplasms, Ovarian Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT06582849 2025-08-26

EARN

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmSarcomaThoracic

33 enrolled

Anus Neoplasms, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms

NCT05105087 2025-08-22

Gynecological Sentinel Lymph Nodes CEUS

Phase EARLY_PHASE1 Completed

9 enrolled 10 charts

BreastCNSEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETSarcomaThoracic

Uterine Cervical Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT07118176 2025-08-12

Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers

Phase 1 Recruiting

30 enrolled

Adrenal Gland Neoplasms, Anus Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Colorectal Neoplasms, Carcinoma, Medullary, Cholangiocarcinoma, Neuroendocrine Tumors, Solitary Fibrous Tumors

NCT06867445 2025-07-17

MIPEX

64 enrolled

Uterine Cervical Neoplasms, Vaginal Neoplasms

NCT02140021 2025-07-14

Biospecimen Collection and Testing for the Prevalence of Anal Dysplasia and Anal Cancer in Patients With Cervical, Vaginal and Vulvar Dysplasia and Cancer

Phase NA Terminated

409 enrolled

Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT06339827 2025-06-18

ASQ-GYO

70 enrolled

Uterine Cervical Neoplasms, Ovarian Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Gestational Trophoblastic Disease

NCT06023862 2025-06-15

DOVE

198 enrolled

Uterine Cervical Neoplasms, Ovarian Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Adenocarcinoma, Clear Cell

NCT03277482 2025-05-31

Durvalumab, Tremelimumab + Radiotherapy in Gynecologic Cancer

Phase 1 Terminated

16 enrolled

Uterine Cervical Neoplasms, Ovarian Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT05743517 2025-04-29

Physical Activity Intervention Among Older Women With Gynecologic Cancers (Fit4Treatment)

192 enrolled

Uterine Cervical Neoplasms, Motor Activity, Ovarian Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT04278326 2025-04-20

ORGANOIDES

Phase NA Terminated

14 enrolled

Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, Vaginal Neoplasms, Papillomavirus Infections

NCT05995860 2025-01-28

PRECursOr

47 enrolled

Ovarian Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT06292689 2024-11-21

A Phase II, Single-arm, Multicenter, Prospective Study of Cardunolizumab in Recurrent or Metastatic Vulvar and Vaginal Cancer

40 enrolled

Vaginal Neoplasms, Vulvar Neoplasms

NCT06686043 2024-11-13

HPV-VIM

85 enrolled

GastrointestinalGenitourinaryGynecologicHead & Neck

Uterine Cervical Neoplasms, Neoplasm Metastasis, Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Papillomavirus Infections

NCT06544720 2024-08-09

SCG142 TCR-T Cells for Human Papillomavirus-Associated Carcinomas

Phase 1 Recruiting

18 enrolled

Anus Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT06537687 2024-08-05

RACE

91 enrolled

GastrointestinalGenitourinaryGynecologic

Uterine Cervical Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT03439085 2024-07-09

DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers

Phase 2 Terminated

41 enrolled 13 charts

Anal Canal Carcinoma, Anus Neoplasms, Uterine Cervical Neoplasms, Neoplasm Metastasis, Neoplasms, Penile Neoplasms, Recurrence, Vaginal Neoplasms, Vulvar Neoplasms

NCT05051696 2024-06-04

Intra-tumor Injection of Oncolytic Viruses H101 Combined With or Without Radiotherapy in Refractory/Recurrent Gynecological Malignancies

Phase 2 Active not recruiting

120 enrolled

Uterine Cervical Neoplasms, Genital Neoplasms, Female, Ovarian Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT04269837 2024-05-09

Sexual Health Counseling Intervention During Radiation Therapy in Improving Quality of Life for Women With Gynecologic Cancer

4 enrolled

Phase NA Not yet recruiting

Uterine Cervical Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT06392399 2024-05-02

Interventions for the Management of Perineal Cancer Pain

60 enrolled

Rectal Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT03452332 2023-09-13

Stereotactic Body Radiation Therapy, Tremelimumab and Durvalumab in Treating Participants With Recurrent or Metastatic Cervical, Vaginal, or Vulvar Cancers

Phase 1 Completed

20 enrolled

GastrointestinalGenitourinaryGynecologic

Uterine Cervical Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT04066894 2023-08-14

Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study

Phase 2 Terminated

3 enrolled 5 charts

Low Anterior Resection Syndrome, Anus Neoplasms, Urinary Bladder Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Pelvic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT03339765 2023-07-05

Self-Advocacy Serious Game in Advanced Cancer

78 enrolled

BreastGynecologic

Breast Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT05925361 2023-06-29

PeriVaS

Phase NA Unknown

13 enrolled

Mullerian aplasia, Gender Dysphoria, Vaginal Neoplasms

NCT01399658 2023-03-14

AMIGO

Phase 2 Completed

93 enrolled 5 charts

Uterine Cervical Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT05561413 2022-10-03

GEMS

Phase NA Unknown

40 enrolled

Uterine Cervical Neoplasms, Neoplasms, Ovarian Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT03372720 2022-04-22

Fractional CO2 Laser Therapy in Minimizing Genitourinary Syndrome of Menopause in Gynecological Cancer Survivors

19 enrolled

Uterine Cervical Neoplasms, Dyspareunia, Ovarian Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT03956498 2022-03-24

FEMINICOL

60 enrolled

Uterine Cervical Neoplasms, Vaginal Neoplasms

NCT03180294 2022-03-08

Bupropion Hydrochloride in Improving Sexual Desire in Women With Breast or Gynecologic Cancer

Phase 2 Completed

230 enrolled 24 charts

BreastGynecologic

Breast Neoplasms, Uterine Cervical Neoplasms, Ovarian Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms

NCT02058550 2021-08-17

Phone or Email Reminder in Increasing Vaginal Dilator Use in Patients With Gynecologic Cancers Undergoing Brachytherapy

Phase 1 Completed

72 enrolled

Uterine Cervical Neoplasms, Radiation Injuries, Vaginal Neoplasms, Endometrial Neoplasms

NCT01654458 2021-03-18

A Randomized Controlled Trial of an Online Support Group for Sexual Distress Due to Gynecologic Cancer

398 enrolled

GynecologicOther

Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Genital Neoplasms, Female, Ovarian Neoplasms, Urogenital Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Sexual Dysfunctions, Psychological

NCT01097239 2020-11-20

Examining the Role of Transrectal High Intensity Focused Ultrasound (HIFU) in Rectal Pelvic Cancer

Phase 1/2 Withdrawn

Uterine Cervical Neoplasms, Ovarian Neoplasms, Rectal Neoplasms, Vaginal Neoplasms, Endometrial Neoplasms

NCT02714621 2020-07-15

HIFU-Gynae

31 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicOther solid neoplasmThoracic

Uterine Cervical Neoplasms, Ovarian Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms

NCT00066404 2020-05-13

Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions

Phase 1 Completed

Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymoma, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Pleural Effusion, Malignant, Endometrial Neoplasms, Breast Neoplasms, Male, Gestational Trophoblastic Disease, Small Cell Lung Carcinoma

NCT03611517 2020-02-24

SPARC

Phase NA Unknown

220 enrolled

Uterine Cervical Neoplasms, Vaginal Neoplasms, Endometrial Neoplasms, Sexuality

NCT02096783 2019-11-18

Scripted Sexual Health Informational Intervention in Improving Sexual Function in Patients With Gynecologic Cancer

15 enrolled

GynecologicOther

Carcinoma, Ovarian Epithelial, Anxiety Disorders, Uterine Cervical Neoplasms, Sexual Dysfunction, Physiological, Vaginal Neoplasms, Vulvar Neoplasms, Endometrial Neoplasms, Gestational Trophoblastic Disease

NCT03346915 2019-10-09

Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention