Clinical Trials Browser

Has results × Metformin × 1 year × Clear all

Urothelial Cancer

NCT02186847 2026-05-22

Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer

Phase 2 Completed

170 enrolled 19 charts

Thoracic

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung

NCT04414540 2026-05-08

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

Phase 2 Active not recruiting

21 enrolled 12 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT01905046 2026-04-28

Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

Phase 3 Active not recruiting

86 enrolled 10 charts

Breast

Breast Carcinoma In Situ, Carcinoma, Intraductal, Noninfiltrating

NCT02874430 2026-04-22

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

Phase 2 Terminated

29 enrolled 11 charts

Breast

Breast Neoplasms

NCT02581137 2026-04-13

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

Phase 2 Active not recruiting

26 enrolled 10 charts

Head & Neck

Erythroplasia, Hyperplasia, Leukoplakia, Oral, Mouth Neoplasms

NCT02122185 2026-03-27

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 2 Completed

111 enrolled 15 charts

GynecologicThoracic

Carcinoma, Ovarian Epithelial, Brenner Tumor, Fallopian Tube Neoplasms, Pleural Effusion, Malignant

NCT02946996 2026-03-05

Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

Phase 2 Terminated

41 enrolled 8 charts

Genitourinary

Prostatic Neoplasms

NCT04850846 2026-02-09

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Phase 2 Active not recruiting

60 enrolled 10 charts

Plasma cell

Smoldering Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance

NCT03109847 2025-12-11

Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers

Phase 2 Terminated

13 enrolled 8 charts

Head & Neck

Thyroid Diseases

NCT02500147 2025-07-02

Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS)

Phase 4 Terminated

3 enrolled 5 charts

Acne Vulgaris, Amenorrhea, Hirsutism, Polycystic Ovary Syndrome, Metabolic Syndrome, Dyslipidemias, Non-alcoholic Fatty Liver Disease

Clinical Trials

An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

Metformin Hydrochloride in Preventing Breast Cancer in Patients With Atypical Hyperplasia or In Situ Breast Cancer

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers

Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS)