Clinical Trials

Esophageal Neoplasms

NCT04693377 2026-04-15

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

40 enrolled

Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Melanoma, Neoplasm Metastasis, Prostatic Neoplasms, Sarcoma, Thyroid Neoplasms, Colorectal Neoplasms

NCT03546686 2026-03-27

Peri-Operative Immune Checkpoint Inhibition and Cryoablation in Women With Triple-negative Breast Cancer

Phase 2 Active not recruiting

51 enrolled

Phase NA Not yet recruiting

Breast Neoplasms

NCT07398118 2026-03-23

CRYO-1

61 enrolled

Phase 2 Not yet recruiting

Breast Neoplasms

NCT07450352 2026-03-04

SEED-CRYO: Sequential 125I Seed Implantation Followed by Cryoablation vs Single-Modality Local Therapy in Unresectable Solid Tumors

150 enrolled

Other solid neoplasm

Unresectable Solid Tumors

NCT07437625 2026-02-27

Lesion-Allocated Therapy for Multiple Metastases and Tumor-Zoned Treatment for Bulky Tumors: A Phase II Study of Iodine-125 Seed Implantation Combined With Cryoablation in High-Burden Metastatic Disease

Phase 2 Not yet recruiting

90 enrolled

Other solid neoplasm

High-Burden Metastatic Solid Tumors

NCT07439432 2026-02-27

Stereotactic Guided Biopsy and Cryoablation

Phase NA Withdrawn

Breast Neoplasms

NCT07416448 2026-02-18

NAP-C/R

Phase NA Active not recruiting

50 enrolled

Agnosia, Hypesthesia, Neuralgia, Neuroma

NCT04150939 2026-02-17

Cryoablation for the Treatment of Metastatic Cancer

15 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT06593106 2026-02-02

Cryodevitalization for the Treatment of Early Stage Lung Cancer, CRYSTAL Trial

30 enrolled

Lung Neoplasms

NCT04339218 2026-01-30

CRYOMUNE

Phase 3 Recruiting

214 enrolled

Adenocarcinoma of Lung

NCT04701918 2026-01-22

Cryoablation With Pembrolizumab Or Avelumab In Urothelial Carcinoma

Phase 2 Completed

9 enrolled

Genitourinary

Urinary Bladder Neoplasms, Carcinoma, Transitional Cell

NCT07232433 2026-01-22

Safety and Efficacy Evaluation of Cryoablation in the Treatment of Ground-Glass Nodules

90 enrolled

Lung Neoplasms

NCT05779423 2026-01-06

Cryoablation+Ipilimumab+Nivolumab in Melanoma

37 enrolled

Dermatologic

Melanoma, Skin Neoplasms

NCT07306286 2025-12-29

Cryoablation Combined With the Dual-Function Antibody PD-1/CTLA-4 for the Treatment of LAPC Following Failure of First-Line AG Therapy

20 enrolled

Phase NA Active not recruiting

Pancreatic Adenocarcinoma Locally Advanced

NCT07272356 2025-12-09

Evaluation of Efficacy of Minimally Invasive Local Therapy for Lung Tumors and Its Impact on Breathing Function

68 enrolled

Carcinoma, Non-Small-Cell Lung, Respiratory Aspiration

NCT06081400 2025-11-19

CRYODESMO-02

Phase 1/2 Not yet recruiting

150 enrolled

Sarcoma

Desmoid Tumors

NCT05806385 2025-09-09

LOGIC

36 enrolled

Triple Negative Breast Neoplasms

NCT05949099 2025-09-08

Study of Cryoablation and Nirogacestat for Desmoid Tumor

28 enrolled

Sarcoma

Desmoid Tumors

NCT06127303 2025-09-05

Toripalimab Combined With Cryoablation for First-line Oligo-progression in Driver-negative Advanced NSCLC

54 enrolled

Carcinoma, Non-Small-Cell Lung

NCT07070700 2025-08-12

CASTLE-ZS-02

56 enrolled

Cirrhosis, Familial, with Pulmonary Hypertension, Cholangiocarcinoma

NCT02534233 2025-08-01

ColdPlay2

Phase NA Completed

58 enrolled 10 charts

Barrett Esophagus, Esophageal Neoplasms

NCT06839001 2025-06-26

CRYSTAL - SIX

Phase 3 Recruiting

750 enrolled

Breast Neoplasms

NCT03325101 2025-06-12

Dendritic Cell Therapy With Pembrolizumab for Metastatic or Unresectable Melanoma

Phase 1/2 Terminated

7 enrolled 11 charts

Dermatologic

Melanoma

NCT06246968 2025-05-21

A Study of Pembrolizumab and Cryoablation in People With Breast Cancer

Phase 1 Recruiting

30 enrolled

Breast Neoplasms, Triple Negative Breast Neoplasms

NCT02380443 2025-05-16

AlloStim® Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer

Phase 2 Completed

13 enrolled 8 charts