Announcements Trials
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Phase

Phase 2 3Phase 1/2 1Phase 1 1

Status

Active not recruiting 3Recruiting 2Terminated 1

Sponsor Class

OTHER 5INDUSTRY 1

Study Type

Interventional 5Observational 1

Sponsor

Cancer Type

Breast 3Thoracic 2Genitourinary 1CNS 1

Conditions

Breast Neoplasms 3Urologic Neoplasms 1Pleural Neoplasms 1Neurofibromatosis 2 1Carcinoma, Non-Small-Cell Lung 1

Interventions

pembrolizumab 1265Specimen Handling 926Magnetic Resonance Spectroscopy 830Carboplatin 823Cyclophosphamide 800Cisplatin 723Nivolumab 669Paclitaxel 627Radiotherapy 611Gemcitabine 573Biopsy 557Bevacizumab 478Dexamethasone 438fludarabine 407Docetaxel 380venetoclax 368Oxaliplatin 364Capecitabine 358Fluorouracil 355atezolizumab 350durvalumab 332Rituximab 330Drug Therapy 326Doxorubicin 316Radiosurgery 315Standard of Care 309Blood Specimen Collection 308Pemetrexed 305Ipilimumab 299Radiation 286

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
Doxycycline × 1 year × Clear all
NCT06120140 2026-06-05

COCOON

Janssen Research & Development, LLC

Phase 2 Active not recruiting
305 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung

NCT02874430 2026-04-22

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

Thomas Jefferson University

Phase 2 Terminated
29 enrolled 11 charts
Breast

Breast Neoplasms

NCT03435952 2026-04-16

Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT

M.D. Anderson Cancer Center

Phase 1 Active not recruiting
18 enrolled
BreastGenitourinary

Breast Neoplasms, Urologic Neoplasms

NCT03465774 2026-03-05

Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions

M.D. Anderson Cancer Center

Recruiting
208 enrolled
Thoracic

Pleural Neoplasms

NCT06452394 2025-12-30

NEODOXy: Targeting Breast Cancer Stem Cells With Doxycycline

Swiss Cancer Institute

Phase 2 Recruiting
50 enrolled
Breast

Breast Neoplasms

NCT05521048 2025-12-08

Doxycycline in Cutaneous Schwannoma (NF2)

Massachusetts Eye and Ear Infirmary

Phase 1/2 Active not recruiting
19 enrolled
CNS

Neurofibromatosis 2

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