Clinical Trials

Phase 3 Active not recruiting

Fibrolamellar hepatocellular carcinoma, Carcinoma, Hepatocellular, Neoplasms

NCT03017326 2026-05-13

PHITT

450 enrolled

Carcinoma, Hepatocellular, Hepatoblastoma

NCT01840592 2026-05-06

Sorafenib Plus Doxorubicin in Patients With Advanced Hepatocellular Carcinoma With Disease Progression on Sorafenib

30 enrolled

Carcinoma, Hepatocellular

NCT02559778 2026-04-28

PEDS-PLAN

Phase 2 Recruiting

500 enrolled

CNS

Neuroblastoma

NCT01871766 2026-04-24

Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy

115 enrolled

Sarcoma

Rhabdomyosarcoma

NCT03164057 2026-04-23

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

MyeloidOther hematologic neoplasm

206 enrolled

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT01187199 2026-04-16

Phase I Trial of Bevacizumab and Temsirolimus in Combination With 1) Carboplatin, 2) Paclitaxel, 3) Sorafenib for the Treatment of Advanced Cancer

Phase 1 Active not recruiting

278 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT03132454 2026-04-15

Palbociclib and Sorafenib, Decitabine, or Dexamethasone in Treating Patients With Recurrent or Refractory Leukemia

Phase 1 Active not recruiting

32 enrolled

LymphoidOther hematologic neoplasm

Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT05068752 2026-03-30

Phase II Trial of Vemurafenib and Sorafenib in Pancreatic Cancer

10 enrolled 15 charts

Phase 1 Active not recruiting

Neoplasm Metastasis, Pancreatic Neoplasms

NCT02298348 2026-03-23

N2013-02

18 enrolled

CNS

Neuroblastoma, Recurrence

NCT07463651 2026-03-20

TROPHY-15

Phase 3 Recruiting

594 enrolled

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT01946529 2026-02-23

Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors

24 enrolled 11 charts

Neuroectodermal Tumors, Primitive, Peripheral, Desmoplastic Small Round Cell Tumor

NCT02143726 2026-02-11

Sorafenib Tosylate With or Without Everolimus in Treating Patients With Advanced, Radioactive Iodine Refractory Hurthle Cell Thyroid Cancer

35 enrolled 14 charts

EndocrineHead & Neck

Thyroid cancer, Hurthle cell

NCT00989469 2026-02-05

NEXIRI

Phase 1/2 Completed

64 enrolled

Colorectal Neoplasms

NCT01715441 2026-02-05

NEXIRI2

173 enrolled

Metastatic Colorectal Cancer Patients With KRAS Mutated Tumors

NCT03211416 2026-02-05

Sorafenib Tosylate and Pembrolizumab in Treating Patients With Advanced or Metastatic Liver Cancer

Phase 1/2 Completed

37 enrolled 13 charts

Carcinoma, Hepatocellular

NCT00826540 2026-01-20

Sorafenib and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

83 enrolled 10 charts

Colonic Neoplasms, Rectal Neoplasms

NCT00494182 2025-12-17

Sorafenib in Combination With Carboplatin and Paclitaxel in Treating Participants With Metastatic or Recurrent Head and Neck Squamous Cell Cancer

Phase 1/2 Active not recruiting

48 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT03247088 2025-12-15

Sorafenib, Busulfan and Fludarabine in Treating Patients With Recurrent or Refractory Acute Myeloid Leukemia Undergoing Donor Stem Cell Transplant

74 enrolled

Other hematologic neoplasm

Leukemia, Myeloid, Acute

NCT07264010 2025-12-04

Sorafenib Combined With Venetoclax as Pre-emptive Therapy Strategy for MRD+ AML: a Prospective, Single-arm, Multicenter Clinical Study

Phase 2/3 Not yet recruiting

87 enrolled

Other hematologic neoplasm

Leukemia, Myeloid, Acute, Neoplasm, Residual

NCT03037437 2025-09-04

Sorafenib Induced Autophagy Using Hydroxychloroquine in Hepatocellular Cancer

64 enrolled

Liver Neoplasms

NCT02029001 2025-08-07

MOST plus

Phase 2 Recruiting

900 enrolled

Tumor-Agnostic

Neoplasm Metastasis

NCT01141309 2025-07-22

Evaluating the Combination of Everolimus and Sorafenib in the Treatment of Thyroid Cancer