Announcements Trials
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Phase

Phase 2 3Phase 3 2

Status

Recruiting 5Not yet recruiting 3Terminated 1

Sponsor Class

OTHER 4NETWORK 1

Study Type

Interventional 5

Sponsor

Cancer Type

CNS 4Thoracic 1Breast 1

Conditions

Brain Neoplasms 4Small Cell Lung Carcinoma 1Motor Activity 1Lung Neoplasms 1Cognitive Dysfunction 1Breast Neoplasms 1

Interventions

Specimen Handling 311Magnetic Resonance Spectroscopy 266pembrolizumab 251Carboplatin 184Cyclophosphamide 176Biopsy 172Cisplatin 157Gemcitabine 134Paclitaxel 131Bevacizumab 124fludarabine 117Radiotherapy 108Nivolumab 108Oxaliplatin 88Docetaxel 87Fluorouracil 85Capecitabine 83venetoclax 82Dexamethasone 77Pemetrexed 72Rituximab 71Leucovorin 69Drug Therapy 69atezolizumab 67durvalumab 66Radiosurgery 65Blood Specimen Collection 65Standard of Care 63Doxorubicin 63Radiation 61

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Recruiting × Memantine × 90 days × Clear all
NCT03550391 2026-05-12

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Canadian Cancer Trials Group

Phase 3 Recruiting
206 enrolled
CNS

Brain Neoplasms

NCT06727773 2026-05-06

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

UNC Lineberger Comprehensive Cancer Center

Phase 2 Recruiting
90 enrolled
Breast

Breast Neoplasms, Motor Activity, Cognitive Dysfunction

NCT04804644 2026-05-04

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

NRG Oncology

Phase 3 Recruiting
200 enrolled
CNSThoracic

Brain Neoplasms, Lung Neoplasms, Small Cell Lung Carcinoma

NCT05045950 2026-05-01

Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

Medical College of Wisconsin

Phase 2 Recruiting
53 enrolled
CNS

Brain Neoplasms

NCT05013892 2026-04-16

NTS-WBRT in Brain Metastases

Massachusetts General Hospital

Phase 2 Recruiting
41 enrolled
CNS

Brain Neoplasms

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