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NCT06875310 2026-04-07A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)Mirati Therapeutics Inc.Phase 3 Recruiting630 enrolled
NCT05853575 2026-03-27Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21)Mirati Therapeutics Inc.Phase 2 Active not recruiting200 enrolled
NCT04613596 2026-03-18Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7Mirati Therapeutics Inc.Phase 2/3 Recruiting806 enrolled
NCT05578092 2026-02-19A Phase 1 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK PathwayMirati Therapeutics Inc.Phase 1 Terminated64 enrolled