Clinical Trials

Phase EARLY_PHASE1 Terminated

Breast Neoplasms

NCT03151005 2023-12-04

The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS

Phase 4 Completed

70 enrolled 11 charts

Other

Obesity, Polycystic Ovary Syndrome, Overweight

NCT03477162 2023-10-03

Metformin Pharmacology in Human Cancers: A Proof of Principle Study

18 enrolled 10 charts

Thoracic Neoplasms

NCT01101438 2023-09-13

A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer

Phase 3 Completed

3,649 enrolled 17 charts

Breast Neoplasms, Breast Neoplasms, Male

NCT02949700 2023-06-29

Phase I/II Study OF Metformin in Combination With Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma

Phase 1/2 Completed

26 enrolled 14 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02028221 2023-06-27

Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk

151 enrolled 15 charts

Breast Cancer Prevention

NCT02420652 2023-02-08

PRIMA

27 enrolled 6 charts

Prostatic Neoplasms

NCT00930579 2022-10-20

Pre-Surgical Study: Effect of Metformin on Breast Cancer Proliferation

35 enrolled 5 charts

Breast Neoplasms

NCT02176161 2022-10-18

Metformin Prostate Cancer Adjuvant Trial

59 enrolled 8 charts

Prostatic Neoplasms

NCT02531308 2022-09-28

DLBCL

5 enrolled 5 charts

LymphoidSarcoma

Lymphoma, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating

NCT02614859 2022-03-29

BIMET-1

29 enrolled 10 charts

Prostatic Neoplasms

NCT01482286 2022-03-15

PULSE

Phase 3 Terminated

32 enrolled 10 charts

Body Weight, Insulin Resistance, Motor Activity, Polycystic Ovary Syndrome

NCT00038727 2021-12-28

DPPOS

Phase 3 Unknown

2,779 enrolled 16 charts

Other

Diabetes Mellitus, Diabetes Mellitus, Type 2, Neoplasms, Obesity, Prediabetic State

NCT02065687 2021-09-30

Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer

Phase 2/3 Unknown

469 enrolled 16 charts

Gynecologic

Endometrial Adenocarcinoma

NCT01666730 2021-08-10

Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer

50 enrolled 13 charts

Gastrointestinal

Pancreatic Neoplasms

NCT01310231 2021-04-14

A Trial of Standard Chemotherapy With Metformin (vs Placebo) in Women With Metastatic Breast Cancer

40 enrolled 27 charts

Breast Neoplasms

NCT02635386 2021-01-29

EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)

Phase 3 Completed

119 enrolled 34 charts

Other

Obesity, Polycystic Ovary Syndrome

NCT02495103 2021-01-26

Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma

Phase 1/2 Terminated

7 enrolled 10 charts

Carcinoma, Renal Cell

NCT01427595 2021-01-08

Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone

Phase NA Completed

25 enrolled 6 charts

Polycystic Ovary Syndrome, Hyperandrogenism

NCT03048500 2020-10-14

Nivolumab and Metformin Hydrochloride in Treating Patients With Stage III-IV Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Phase 2 Unknown

17 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung

NCT01627067 2020-06-19

Exemestane-RAD001-Metformin

23 enrolled 7 charts

Breast Neoplasms

NCT02325401 2020-06-11

Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 1 Completed

20 enrolled 11 charts

Head & Neck

Head and Neck Neoplasms

NCT01302379 2020-06-05

Reach for Health Study: Obesity-related Mechanisms and Mortality in Breast Cancer Survivors

Phase NA Completed

333 enrolled 17 charts

BreastOther

Breast Neoplasms, Obesity, Weight Loss

NCT01717482 2020-03-10

Metformin as a Chemoprevention Agent in Non-small Cell Lung Cancer

6 enrolled 5 charts

Phase EARLY_PHASE1 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03117517 2020-03-02

Treatment With Metformin and Combination of Metformin and Pioglitazone in Polycystic Ovarian Syndrome

106 enrolled 7 charts

Polycystic Ovary Syndrome

NCT02285855 2020-01-06

Metformin in Non Small Cell Lung Cancer (NSCLC)

27 enrolled 11 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02472353 2019-10-16

Use of Metformin to Reduce Cardiac Toxicity in Breast Cancer

30 enrolled 10 charts

Breast Neoplasms, Neoplasms, Cardiotoxicity

NCT01312467 2019-03-05

Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI

Other hematologic neoplasm

45 enrolled 7 charts

GastrointestinalOther

Obesity, Colorectal Neoplasms, Adenomatous Polyps

NCT01849276 2019-01-31

Metformin+Cytarabine for the Treatment of Relapsed/Refractory AML

Phase 1 Terminated

2 enrolled 9 charts

Congenital Abnormalities, Blast Crisis, Leukemia, Erythroblastic, Acute, Leukemia, Megakaryoblastic, Acute, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Acute

NCT01578551 2018-12-19

Study of Metformin Plus Paclitaxel/Carboplatin/Bevacizumab in Patients With Adenocarcinoma.

25 enrolled 9 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung

NCT01340300 2018-06-06

Exercise and Metformin in Colorectal and Breast Cancer Survivors

139 enrolled 18 charts

BreastGastrointestinal

Breast Neoplasms, Insulin Resistance, Motor Activity, Colorectal Neoplasms

NCT01579812 2018-05-25

Evaluation of Metformin, Targeting Cancer Stem Cells for Prevention of Relapse in Gynecologic Patients

90 enrolled 9 charts

Gynecologic

Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

NCT01620593 2018-05-23

Castration Compared to Castration Plus Metformin as First Line Treatment for Patients With Advanced Prostate Cancer

41 enrolled 7 charts

Prostatic Neoplasms

NCT02019979 2018-05-04

METRO

14 enrolled 7 charts

Lung Neoplasms

NCT00151411 2018-03-21

Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS)

114 enrolled 10 charts

Anovulation, Polycystic Ovary Syndrome

NCT01433913 2018-01-10

Metformin Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery

20 enrolled 17 charts