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NCT04804709 2025-06-08

Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)

Phase 1 Terminated

5 enrolled 11 charts

Diffuse Intrinsic Pontine Glioma

NCT02506959 2025-03-18

Panobinostat, Gemcitabine Hydrochloride, Busulfan, and Melphalan Before Stem Cell Transplant in Treating Patients With Refractory or Relapsed Multiple Myeloma

Phase 2 Completed

83 enrolled 11 charts

Other hematologic neoplasmPlasma cell

Leukemia, Plasma Cell, Multiple Myeloma, Plasmacytoma

NCT02654990 2024-07-12

PANORAMA_3

Phase 2 Completed

248 enrolled 28 charts

Multiple Myeloma, Recurrence

NCT02717455 2024-04-25

PBTC-047

Phase 1 Completed

53 enrolled 25 charts

Diffuse Intrinsic Pontine Glioma, Glioma

NCT02032810 2023-01-20

Phase I of Histone Deacetylase (HDAC) Inhibitor Panobinostat With Ipilimumab With Unresectable III/IV Melanoma

Phase 1 Completed

17 enrolled 12 charts

Melanoma, Skin Neoplasms

NCT02722941 2022-11-01

Panobinostat (LBH589): Multiple Myeloma - Autologous Hematopoietic Cell Transplantation (HCT)

Phase 2 Completed

30 enrolled 12 charts

Multiple Myeloma

NCT01582009 2022-08-15

Panobinostat and Everolimus in Treating Patients With Metastatic or Unresectable Renal Cell Cancer That Does Not Respond to Treatment With Sunitinib Malate or Sorafenib Tosylate

Phase 1/2 Terminated

26 enrolled 11 charts

Carcinoma, Renal Cell

NCT01261247 2022-05-24

Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

Phase 2 Completed

41 enrolled 8 charts

LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Immunoblastic Lymphadenopathy, Lymphoma, Follicular, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Peripheral, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell

NCT03256045 2022-05-09

Panobinostat, Carfilzomib, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma

Phase 2 Terminated

9 enrolled 12 charts

Multiple Myeloma

NCT01496118 2022-02-02

Study of the Combination of Panobinostat and Carfilzomib in Patients With Relapsed/Refractory Multiple Myeloma

Phase 1/2 Completed

80 enrolled 20 charts

Multiple Myeloma

NCT00550277 2021-11-23

LBH589 Treatment for Refractory Clear Cell Renal Carcinoma

Phase 2 Completed

20 enrolled 7 charts

Carcinoma, Renal Cell

NCT00425555 2021-08-20

Study of Oral LBH589 in Adult Patients With Refractory Cutaneous T-Cell Lymphoma

Phase 2 Completed

139 enrolled 21 charts

DermatologicLymphoid

Mycosis Fungoides, Sezary Syndrome, Lymphoma, T-Cell, Cutaneous

NCT00490776 2021-08-18

Study of Oral LBH589 in Adult Participants With Refractory/Resistant Cutaneous T-Cell Lymphoma (CTCL)

Phase 2 Terminated

9 enrolled 6 charts

DermatologicLymphoid

Mycosis Fungoides, Sezary Syndrome, Lymphoma, T-Cell, Cutaneous

NCT00742027 2021-07-28

Phase II Study of Oral Panobinostat in Adult Participants With Relapsed/Refractory Classical Hodgkin's Lymphoma

Phase 2 Completed

129 enrolled 16 charts

Hodgkin Disease

NCT00449761 2021-07-15

Efficacy and Safety of LBH589B in Adult Patients With Refractory Chronic Myeloid Leukemia in Accelerated or Blast Phase

Phase 2 Terminated

27 enrolled 14 charts

MyeloidOther hematologic neoplasm

Blast Crisis, Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive

NCT00445068 2021-07-14

Efficacy and Safety of LBH589B in Adult Patients With Multiple Myeloma

Phase 2 Terminated

38 enrolled 13 charts

Multiple Myeloma

NCT00667862 2021-06-21

Efficacy and Safety Study of Panobinostat in Participants With Metastatic Hormone Refractory Prostate Cancer

Phase 2 Completed

35 enrolled 8 charts

Adenocarcinoma, Neoplasm Metastasis, Neoplasms, Prostatic Neoplasms

NCT00936611 2021-01-28

LBH589 in Relapsed or Relapsed and Refractory Waldenstrom's Macroglobulinemia

Phase 2 Completed

39 enrolled 13 charts

Waldenstrom Macroglobulinemia, Recurrence

NCT01169636 2021-01-06

Panobinostat Plus Ifosfamide, Carboplatin, and Etoposide (ICE) Compared With ICE For Relapsed Hodgkin Lymphoma

Phase 1/2 Completed

62 enrolled 13 charts

Hodgkin Disease

NCT00621244 2021-01-05

A Study of Oral LBH589 in Adult Patients With Advanced Hematological Malignancies

Phase 1/2 Completed

175 enrolled 25 charts

LymphoidOther hematologic neoplasmPlasma cell

Leukemia, Lymphoma, Multiple Myeloma

NCT00946647 2020-08-04

A Phase Ib/IIb, Open-label, Multi-center, Study of Oral Panobinostat Administered With 5-Azacitidine (in Adult Patients With Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML).

Phase 1/2 Completed

113 enrolled 21 charts

MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic

NCT01023308 2020-03-17

PANORAMA-1

Phase 3 Completed

767 enrolled 17 charts

Multiple Myeloma, Recurrence, Neoplasms, Plasma Cell

NCT00918333 2020-03-10

Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma

Phase 1/2 Completed

124 enrolled 10 charts

DermatologicLymphoidOther hematologic neoplasmPlasma cell

Burkitt Lymphoma, Hodgkin Disease, Immunoblastic Lymphadenopathy, Lymphoma, Follicular, Waldenstrom Macroglobulinemia, Multiple Myeloma, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell

NCT02057640 2019-12-11

MLN9708 (Ixazomib) in Combination With Panobinostat and Dexamethasone in Multiple Myeloma

Phase 1/2 Completed

16 enrolled 12 charts

Multiple Myeloma

NCT00985946 2019-12-09

Study of Panobinostat in Patients With Neuroendocrine Tumors

Phase 2 Terminated

15 enrolled 11 charts

Neuroendocrine Tumors

NCT01802879 2019-12-06

Study to Allow Access to Single Agent Panobinostat for Patients Who Are on s.a. Panobinostat Treatment in a Novartis-sponsored Study and Continue to Benefit From the Treatment as Judged by the Investigator

Phase 2 Completed

9 enrolled 8 charts

Other hematologic neoplasm

Hematologic Neoplasms

NCT01013597 2019-11-29

Trial of LBH589 in Metastatic Thyroid Cancer

Phase 2 Completed

13 enrolled 11 charts

Thyroid Diseases, Thyroid Neoplasms

NCT01523834 2019-11-22

FIL_PanAL10

Phase 2 Completed

35 enrolled 10 charts

Lymphoma, Large B-Cell, Diffuse

NCT02290431 2019-11-18

Study of Panobinostat in Combination With Bortezomib and Dexamethasone in Japanese Patients With Relapsed/Refractory Multiple Myeloma

Phase 2 Completed

31 enrolled 19 charts

Multiple Myeloma, Recurrence

NCT02518750 2019-04-03

Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma

Phase 2 Terminated

3 enrolled 6 charts

LymphoidOther hematologic neoplasm

Lymphoma, Non-Hodgkin, Leukemia, B-Cell, Leukemia, T-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00939159 2018-08-23

Study of LBH589 for Patients With Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)

Phase 2 Terminated

17 enrolled 5 charts

Myelodysplastic Syndromes, Neoplasms

NCT02720510 2018-07-24

PANORAMA4

Phase 2 Terminated

6 enrolled 7 charts

Multiple Myeloma

NCT01651039 2018-04-09

Phase II, Single-Center, Oral Panobinostat in Combination With Lenalidomide and Dexamethasone in Multiple Myeloma (MM)

Phase 2 Completed

32 enrolled 21 charts

Multiple Myeloma

NCT00878436 2018-02-07

Safety and Efficacy Studies of Panobinostat and Bicalutamide in Patients With Recurrent Prostate Cancer After Castration

Phase 1/2 Completed

52 enrolled 8 charts

Prostatic Neoplasms, Bulbo-Spinal Atrophy, X-Linked

NCT01056601 2017-12-28

Panobinostat & Bortezomib in Pancreatic Cancer Progressing on Gemcitabine Therapy

Phase 2 Terminated

7 enrolled 8 charts

EndocrineGastrointestinal

Glucagonoma, Insulinoma, Pancreatic Neoplasms, Somatostatinoma

NCT01083602 2017-12-21

MACS1271

Phase 2 Completed

55 enrolled 11 charts

Multiple Myeloma, Recurrence

NCT01460940 2017-11-14

A Phase II Trial of Panobinostat and Lenalidomide in Patients With Relapsed or Refractory Hodgkin's Lymphoma

Phase 2 Completed

24 enrolled 7 charts

Hodgkin Disease

NCT00925132 2017-07-02

Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostat

Phase 1/2 Terminated

39 enrolled 8 charts

Melanoma, Neoplasm Metastasis

NCT01105312 2017-06-27

Panobinostat and Letrozole in Treating Patients With Metastatic Breast Cancer

Phase 1/2 Completed

28 enrolled 13 charts

Breast Neoplasms, Breast Neoplasms, Male, Triple Negative Breast Neoplasms

NCT01282476 2017-05-09

Panobinostat With Rituximab for Relapsed/Refractory Diffuse Large B Cell Lymphoma

Phase 2 Terminated

18 enrolled 20 charts

LymphoidSarcoma

Lymphoma, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating

NCT00859222 2017-03-14

LBH589 and Bevacizumab in Patients With Recurrent High Grade Glioma

Phase 1/2 Completed

51 enrolled 18 charts

Glioma

NCT00880269 2017-02-23

Efficacy and Safety of Panobinostat (LBH589) in Patients With Refractory de Novo or Secondary Acute Myelogenous Leukemia (AML)

Phase 2 Completed

59 enrolled 7 charts

Other hematologic neoplasm

Leukemia, Leukemia, Myeloid, Acute

NCT00978432 2016-11-25

Epigenetic Modulation in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

Phase 2 Terminated

50 enrolled 11 charts

Recurrence, Lymphoma, Large B-Cell, Diffuse

NCT00691938 2016-10-13

LBH589 Plus Decitabine for Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukemia (AML)

Phase 1/2 Completed

52 enrolled 18 charts

MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT00777049 2016-07-15

Study of Panobinostat Monotherapy in Women With HER2-negative Locally Recurrent or Metastatic Breast Cancer

Phase 2 Completed

54 enrolled 12 charts

Breast Neoplasms

NCT01034163 2016-07-07

PATH

Phase 3 Completed

41 enrolled 7 charts

Hodgkin Disease

NCT00567879 2016-05-09

A Trial of Panobinostat and Trastuzumab for Adult Female Patients With HER2 Positive Metastatic Breast Cancer (MBC) Whose Disease Has Progressed on or After Trastuzumab

Phase 1/2 Terminated

56 enrolled 5 charts

Breast Neoplasms

NCT00777335 2015-11-24

Study of Panobinostat Monotherapy in Women With v-ERB-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (HER2) Positive Locally Recurrent or Metastatic Breast Cancer

Phase 2 Terminated

4 enrolled 11 charts

Breast Neoplasms

NCT00632489 2015-06-08

LBH589 in Combination With Capecitabine Plus/Minus (±) Lapatinib in Breast Cancer Patients

Phase 1 Completed

20 enrolled 5 charts

Breast Neoplasms, Neoplasms

NCT00967044 2015-02-26

Panobinostat (LBH589) Plus Everolimus (RAD001) in Patients With Relapsed and Refractory Lymphoma

Phase 1/2 Completed

31 enrolled 6 charts

Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Recurrence