Announcements Trials
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Phase

Phase 1/2 3Phase 2 2Phase 1 1

Status

Terminated 4Completed 2

Sponsor Class

OTHER 6

Study Type

Interventional 6

Sponsor

Cancer Type

CNS 6Sarcoma 1Breast 1

Conditions

Neuroblastoma 3Brain Neoplasms 3Medulloblastoma 2Glioblastoma 2Recurrence 1Gliosarcoma 1Central Nervous System Neoplasms 1Breast Neoplasms 1

Interventions

Cyclophosphamide 910Carboplatin 788pembrolizumab 747Paclitaxel 744Bevacizumab 716Cisplatin 709Gemcitabine 621Docetaxel 584Rituximab 558Radiotherapy 548Dexamethasone 511Nivolumab 491Doxorubicin 445Fluorouracil 392Capecitabine 382Etoposide 358Pemetrexed 339Cytarabine 335Oxaliplatin 335Lenalidomide 328Prednisone 327Erlotinib Hydrochloride 323fludarabine phosphate 316Trastuzumab 305Leucovorin 299fludarabine 296Vincristine 288Bortezomib 284Filgrastim 284Cetuximab 277

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
Has results × TPI-287 × Clear all
NCT00867568 2024-08-06

TPI 287 in Patients With Refractory or Recurrent Neuroblastoma or Medulloblastoma

Milton S. Hershey Medical Center

Phase 1 Completed
18 enrolled 12 charts
CNS

Medulloblastoma, Neuroblastoma, Recurrence

NCT01483820 2024-08-06

Safety and Efficacy Study of TPI-287 in Neuroblastoma and Medulloblastoma

Milton S. Hershey Medical Center

Phase 1/2 Terminated
8 enrolled 9 charts
CNS

Medulloblastoma, Neuroblastoma

NCT01505608 2024-08-06

Randomized Efficacy Study of TPI 287 to Treat Primary Refractory or Early Relapsed Neuroblastoma

Milton S. Hershey Medical Center

Phase 1/2 Terminated
14 enrolled 11 charts
CNS

Neuroblastoma

NCT01582152 2019-06-05

Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent Glioblastoma

M.D. Anderson Cancer Center

Phase 1/2 Terminated
12 enrolled 7 charts
CNSSarcoma

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01332630 2018-09-20

TPI 287 in Breast Cancer Metastatic to the Brain

M.D. Anderson Cancer Center

Phase 2 Completed
24 enrolled 8 charts
BreastCNS

Brain Neoplasms, Breast Neoplasms

NCT01113463 2016-10-31

TPI 287 in Patients With Recurrent Glioblastoma Multiforme

M.D. Anderson Cancer Center

Phase 2 Terminated
17 enrolled 3 charts
CNS

Brain Neoplasms, Glioblastoma

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