Announcements Trials
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Phase

Phase 2 2Phase 1/2 2Phase 1 1

Status

Completed 14Terminated 5Active not recruiting 2

Sponsor Class

OTHER 4NIH 1

Study Type

Interventional 5

Sponsor

Cancer Type

Thoracic 2Other hematologic neoplasm 2Tumor-Agnostic 1Other solid neoplasm 1Myeloid 1

Conditions

Leukemia, Myeloid, Acute 2Neoplasm Metastasis 1Myelodysplastic Syndromes 1Mesothelioma 1Carcinoma, Non-Small-Cell Lung 1

Interventions

Cyclophosphamide 222pembrolizumab 201Carboplatin 173Cisplatin 168Gemcitabine 167Paclitaxel 155Docetaxel 140Bevacizumab 138Rituximab 137Radiotherapy 137Nivolumab 126Dexamethasone 126Capecitabine 103fludarabine 102Pemetrexed 92fludarabine phosphate 91Fluorouracil 91Doxorubicin 85Oxaliplatin 79Etoposide 77Cytarabine 77Bortezomib 76Erlotinib Hydrochloride 74Leucovorin 72Filgrastim 68Lenalidomide 67Calcium Dobesilate 66Irinotecan 65atezolizumab 63Radiation 61

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Terminated × Has results × pevonedistat × Clear all
NCT03772925 2026-03-03

Pevonedistat and Belinostat in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

National Cancer Institute (NCI)

Phase 1 Terminated
18 enrolled 19 charts
MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Leukemia, Myeloid, Acute

NCT03319537 2024-05-23

Pevonedistat Alone and in Combination With Chemotherapy in Patients With Mesothelioma

Memorial Sloan Kettering Cancer Center

Phase 1/2 Terminated
9 enrolled 9 charts
Other solid neoplasmThoracic

Mesothelioma

NCT03228186 2023-10-23

Trial of Pevonedistat Plus Docetaxel in Patients With Previously Treated Advanced Non-Small Cell Lung Cancer

University of Michigan Rogel Cancer Center

Phase 2 Terminated
40 enrolled 13 charts
Thoracic

Carcinoma, Non-Small-Cell Lung

NCT04800627 2022-12-27

Pevonedistat and Pembrolizumab for the Treatment of dMMR/MSI-H Metastatic or Locally Advanced Unresectable Solid Tumor

M.D. Anderson Cancer Center

Phase 1/2 Terminated
2 enrolled 4 charts
Tumor-Agnostic

Neoplasm Metastasis

NCT03709576 2020-12-16

Pevonedistat and Azacitidine as Maintenance Therapy After Allogeneic Stem Cell Transplantation for Non-Remission AML

Milton S. Hershey Medical Center

Phase 2 Terminated
3 enrolled 9 charts
Other hematologic neoplasm

Leukemia, Myeloid, Acute

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