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NCT01787552 2020-04-15

A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF

Blood Coagulation Disorders, Blood Platelet Disorders, Bone Marrow Diseases, Hematologic Diseases, Hemorrhagic Disorders, Myeloproliferative Disorders, Polycythemia Vera, Thrombocythemia, Essential, Thrombocytosis, Primary Myelofibrosis

NCT01327053 2019-08-28

BOLT

Phase 2 Completed

230 enrolled 26 charts

Dermatologic

Carcinoma, Basal Cell, Skin Neoplasms

NCT01708174 2017-08-11

A Phase II Study of Oral LDE225 in Patients With Hedge-Hog (Hh)-Pathway Activated Relapsed Medulloblastoma (MB)

Phase 2 Completed

22 enrolled 12 charts

CNS

Medulloblastoma, Recurrence

NCT01125800 2017-03-20

A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB

Phase 1/2 Completed

76 enrolled 18 charts

CNSGastrointestinalSarcoma

Astrocytoma, Glioma, Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Hepatoblastoma

NCT01826214 2016-08-30

Study of Efficacy and Safety of LDE225 in Adult Patients With Relapsed/Refractory Acute Leukemia

Phase 2 Completed

70 enrolled 12 charts

LymphoidOther hematologic neoplasm

Leukemia, Recurrence, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT02002689 2016-05-02

SIGNATURE

Phase 2 Terminated

10 enrolled 9 charts

DermatologicGastrointestinalGynecologicOther hematologic neoplasm

Basal Cell Nevus Syndrome, Colonic Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT01350115 2015-10-19

Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)

Phase 2 Completed

10 enrolled 9 charts

Dermatologic

Basal Cell Nevus Syndrome, Carcinoma, Basal Cell