Clinical Trials Browser

Interventional × Has results × sotorasib × Clear all

Advanced/Metastatic Solid Tumors With KRAS p.G12C Mutation

NCT04303780 2026-04-30

Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).

Phase 3 Active not recruiting

345 enrolled 11 charts

Thoracic

KRAS p, G12c Mutated /Advanced Metastatic NSCLC

NCT05054725 2026-01-06

Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

Phase 2 Completed

47 enrolled 17 charts

Thoracic

Bronchial Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Respiratory Tract Diseases, Respiratory Tract Neoplasms

NCT05313009 2025-12-16

Tarlox and Sotorasib in Patients With KRAS G12C Mutations

Phase 1/2 Terminated

5 enrolled 9 charts

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT05374538 2025-05-01

VIC-1911 Monotherapy in Combination With Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer

Phase 1 Terminated

3 enrolled 13 charts

Thoracic

Carcinoma, Non-Small-Cell Lung

NCT05045638 2023-08-14

Effect of Coadministration of Sotorasib on the Pharmacokinetics of Rosuvastatin in Healthy Participants

Phase 1 Completed

13 enrolled 14 charts

Healthy Participants

Clinical Trials

AMG 510 Ethnic Sensitivity Study (CodeBreaK 105).

Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).

Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

Tarlox and Sotorasib in Patients With KRAS G12C Mutations

VIC-1911 Monotherapy in Combination With Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer

Effect of Coadministration of Sotorasib on the Pharmacokinetics of Rosuvastatin in Healthy Participants